Measurement of Cardiac Output in the Dog by the Simultaneous Injection of Dye and Radioactive Red Cells

The Pulmonary Blood Volume in Mitral Stenosis 1

“…Our observations are in accord, however, with our findings in normal dogs (29), as well as those of Dow, Hahn, and Hamilton (30) and those of Lawson, Cantrell, Shaw, Blackburn, and Adams (31). It would appear from these results that the pulmonary capillary bed does contribute to the overall lowering of total body hematocrit in comparison to large vessel hematocrit in patients with mitral stenosis.…”

Determination of Circulating Pulmonary Blood Volume in Dogs by an Arteriovenous Dye Equilibration Method

“…In the normal subject, this is probably a valid assumption. 10 " 13 When pulmonary capillary pressures are elevated to pulmonary edema levels, however, the possibility of significant transcapillary dye loss must be considered. Although this objection also applies to other dye methods, the presumed advantage of more adequate time for mixing afforded by this method also allows longer time for extravascular loss.…”

“…14 The mean circulation time for radioactive red cells also has been shown to be shorter than that for Evans blue. 12 ' 13 The error introduced by the assumption of equal hematocrit can be minimized by simultaneously determining both pulmonary red cell and plasma volumes using tagged cells and dye.…”

The Transport of Radioactive Inorganic Phosphate by the Pulmonary Circulation

“…If the determination of output is repeated when the mixed blood activity levels are still high from a previous injection, an increased dosage is required to keep the statistical reliability of the flow-dilution curves constant. 4 The progressively increasing dosage or decreasing reliability sets a practical limit to the number of determinations which can be made at reasonably short intervals.…”

“…Hematocrits were obtained on two or more carotid samples collected between the time of injection and initial dye appearance, by a standardized centrifuging procedure. 4 Hematocrit values were corrected to 0.95 of the observed values, for occluded plasma.…”