2024
DOI: 10.1101/2024.09.27.615466
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Measurement of cellular traction forces during confined migration

Max A. Hockenberry,
Andrew J. Ulmer,
Johann L. Rapp
et al.

Abstract: To migrate efficiently through tissues, cells must transit through small constrictions within the extracellular matrix. However, in vivo environments are geometrically, mechanically, and chemically complex, and it has been difficult to understand how each of these parameters contribute to the propulsive strategy utilized by cells in these diverse settings. To address this, we employed a sacrificial micromolding approach to generate polymer substrates with tunable stiffness, controlled adhesivity, and user-defi… Show more

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