Measurement of Cerebral Circulation Time by Contrast-Enhanced Doppler Sonography

Hoffmann, Olaf; Weih, Markus; Schreiber, Stephan J.; Einhäupl, Karl M.; Valdueza, José M.

doi:10.1159/000016043

Cited by 25 publications

(22 citation statements)

References 24 publications

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“…The presented values of global CCT, obtained in our group of normal individuals, are within the range of previously published data [2, 4, 5, 14]. …”

Section: Discussionsupporting

confidence: 90%

“…Up to now only few studies are published, trying to establish and apply ultrasound CCT assessment in an experimental or clinical setting [1, 2, 12, 13, 14, 15, 16, 17]. A regional CCT, assessed between the posterior cerebral artery and the vein of Galen by transcranial colour-coded duplex sonography (TCCS) was shown to be prolonged in patients with CADASIL and vascular dementia [12, 13, 17].…”

Section: Discussionmentioning

confidence: 99%

“…Recently we reported a method for the assessment of a global CCT, defined as the time interval between echo-contrast bolus arrival (Levovist ® , Schering, Berlin, Germany) in the distal internal carotid artery (ICA) and the ipsilateral internal jugular vein (IJV) using extracranial Doppler [1, 2]. However, the number of successful measurements was limited by frequent artefacts due to an overlapping of the arterial and venous signal.…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Global Cerebral Circulation Time Using Power Duplex Echo-Contrast Bolus Tracking

Schreiber

Kauert²,

Doepp³

et al. 2003

Cerebrovasc Dis

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Ultrasound assessment of global cerebral circulation time (CCT) using echo-contrast bolus tracking is a new approach to characterise the perfusion status of the human brain. We present the analysis of global CCT in 36 healthy volunteers and one patient with a cerebral arteriovenous malformation (AVM), measured by extracranial power duplex. CCT was defined as the time interval between bolus arrival in the internal carotid artery and internal jugular vein. CCT in the volunteer group was 7.5 ± 1.1 s (mean ± SD). Values did not correlate with age, gender, blood pressure or blood flow velocity. Measurement in the AVM patient revealed a CCT of 1.5 s. Ultrasonographic CCT analysis is a promising new tool for the evaluation of cerebral hemodynamics.

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“…The presented values of global CCT, obtained in our group of normal individuals, are within the range of previously published data [2, 4, 5, 14]. …”

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measurement of Global Cerebral Circulation Time Using Power Duplex Echo-Contrast Bolus Tracking

Schreiber

Kauert²,

Doepp³

et al. 2003

Cerebrovasc Dis

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“…In this study, we introduced a novel method of measuring cerebral circulation times using 320-detector row 4D CTA. The CCT we calculated as the time interval between the arrival of a bolus of contrast medium at the skull base level of the ICA and the arrival of the bolus in the jugular bulb was 5.8 ± 1.4 s, which is in line with previous studies that derived CCT values by means of DSA and contrastenhanced ultrasound [6,7,9]. However, DSA requires invasive arterial catheterization with its well-known inherent risks, stroke being the most feared [10,11].…”

Section: Discussionsupporting

confidence: 79%

Measurement of cerebral circulation times using dynamic whole-brain CT-angiography: feasibility and initial experience

et al. 2011

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The objective of the study was to use 320-detector row 4D CT angiography (CTA) for measuring cerebral circulation times (CCT) and to assess early venous drainage (EVD) and shortening of CCT in arteriovenous malformations (AVM) and to compare with DSA. CCT of 12 physiological patients and five AVM patients were acquired using a 4D CTA protocol by recording cerebrovascular bolus passage time. In the AVM patients EVD time (EVDT) was measured. Identical measurements were performed on DSA for the AVM patients. It was found that the physiological CCTs were 5.8 ± 1.4 s (M ± SD). EVD was seen in all AVMs and resulted in a shortened CCT of 3.4 ± 1.1 s (p = 0.01). There was no significant difference for CCT and EVDT values derived from DSA and 4D CTA. Thus, the CCTs can be measured non-invasively using clinical 4D CTA. Early venous drainage with shortened CCTs was observed by 4D CTA in all five patients with AVMs.

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“…Therefore, we analyzed the cerebral perfusion time in IIH patients as compared to controls using a noninvasive dynamic duplex sonography technique. Cerebral perfusion can be measured using color-coded duplex sonography either transcranially [14,15] or extracranially [16]. Compared to controls, Liebetrau et al [15] observed prolonged CTT in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Intracranial Venous Flow Patterns in Patients with Idiopathic Intracranial Hypertension

et al. 2011

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Objective: To examine the dynamics of intracranial venous flow patterns in patients with idiopathic intracranial hypertension (IIH). Methods: Nonrandomized controlled trial analyzing the difference in cerebral perfusion in 13 IIH patients and 12 healthy controls using contrast-enhanced duplex sonography. In patients, an additional 3D gradient echo magnetic resonance venography (MRV) using a new technique was performed to quantify stenosis of the cerebral sinus. The cerebral perfusion parameters, including cerebral transit time (CTT) and time to peak (TTP), were analyzed. Results: IIH patients had a higher BMI (29.3 [95% CI 26.4, 32.2] vs. 23.3 [95% CI 20.7, 25.9], p = 0.003) and an increased prevalence of headache, but all other clinical characteristics were comparable. The CTT did not differ significantly. The TTP was significantly longer in IIH patients compared to controls (8.5 [95% CI 7.6, 9.4] vs. 7.3 s [95% CI 6.3, 8.1], p = 0.04). Twelve of 13 (92%) IIH patients showed stenosis of the cerebral sinus. Conclusions: Our study is the first to report an altered cerebral venous flow in IIH patients compared to controls using a dynamic ultrasonographic technique. A simplified MRV technique confirms the high prevalence and reliable detection of venous stenosis in IIH patients.

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Measurement of Cerebral Circulation Time by Contrast-Enhanced Doppler Sonography

Cited by 25 publications

References 24 publications

Measurement of Global Cerebral Circulation Time Using Power Duplex Echo-Contrast Bolus Tracking

Measurement of Global Cerebral Circulation Time Using Power Duplex Echo-Contrast Bolus Tracking

Measurement of cerebral circulation times using dynamic whole-brain CT-angiography: feasibility and initial experience

Dynamics of Intracranial Venous Flow Patterns in Patients with Idiopathic Intracranial Hypertension

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