Measurement of daphnoretin in plasma of freely moving rat by liquid chromatography

Lin, Lie‐Chwen; Yang, Kuo-Yi; Chen, Yen-Fei; Wang, Shau‐Chun; Tsai, Tsong-Ru

doi:10.1016/j.chroma.2004.09.041

Cited by 24 publications

(12 citation statements)

References 11 publications

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“…Regarding other coumarins orally administered in rats, 6MC have a similar t 1/2 to that reported for daphnoterine and daphnetin (t 1/2 of 93 ± 26 and ± 262.23 96.31 min respectively) (Wei et al, 2015;Lin et al, 2005;Zhang et al, 2014). For coumarin, half-lives (t 1/2 ) of between 60-240 h were found in humans and other species, such as rats (Lake, 1999).…”

Section: Discussionmentioning

confidence: 55%

In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

Cárdenas

Kratz

Hernández

et al. 2017

Braz. J. Pharm. Sci.

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6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo antiinflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by the Caco-2 cellular model in both the apical-basal (A-B) and basal-apical (B-A) directions. The pharmacokinetics and biodistribution were evaluated in rats after oral and intraperitoneal administration at doses of 200 mg/kg. Transport experiments with Caco-2 cells showed that 6MC presented high permeability at all concentrations evaluated. This finding suggested that 6MC could be transported across the gut wall by passive diffusion. The plasma concentration-time curve showed that the maximum concentration (Cmax) was 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration, with elimination constant of (K e ) 0.0070 min -1 and a short life half time of (T

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Section: Discussionmentioning

confidence: 55%

In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

Cárdenas

Kratz

Hernández

et al. 2017

Braz. J. Pharm. Sci.

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“…28, No. 4, 268-270, http://dx.doi.org/10.1080/14786419.2013 umbelliferone (8) (Iqbal et al 2009), daphnoretin (9) (Lin et al 2005) and carthamidin (10) (Miyake et al 2003).…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents and biological activities from roots ofEnkleia siamensis

Rajachan

Kanokmedhakul

Nasomjai

et al. 2013

Natural Product Research

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Chemical investigation from roots of Enkleia siamensis (Kurz) Nervling resulted in the isolation of 10 compounds. Their structures were established on the basis of 1D and 2D NMR spectroscopic data as linobiflavonoid (1), chamaejasmin (2), 7-O-β-D-glucopyranosylchamaejasmin (3), ormocarpin (4), (-)-wikstromol (5), matairesinol (6), (+)-lariciresinol (7), umbelliferone (8), daphnoretin (9) and carthamidin (10). Compounds 2 and 8 showed cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines. Compounds 1, 2 and 5 showed weak minimum inhibitory requirements to acetylcholinesterase with values ranging from 50 to 1000 ng. In addition, compound 2 exhibited antimalarial activity against Plasmodium falciparum with an IC50 value of 2.32 μg/mL.

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“…Therefore, this system would be useful for determination of the blood levels of endogenous substances as biological markers in animal models and the blood levels of drugs for pharmacokinetic studies [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Alterations in Plasma Levels of Amino Acids after Intracerebroventricular Administration of L-Serine or D-Serine in Conscious and Freely Moving Rats

Fujita¹,

Ishima²,

Horio³

et al. 2008

TOCCHEMJ

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L-Serine has a role in cellular proliferation, being a precursor for protein synthesis, and is also important for brain development. D-Serine plays a role as the endogenous co-agonist at the glycine site on the N-methyl-D-aspartate (NMDA) receptors in the brain. Accumulating evidence suggests that abnormality of D-serine levels might be involved in the pathophysiology of schizophrenia. Using the automated blood sampling system, we examined whether or not intracerebroventricular (icv) infusion of L-and D-isomers of serine could affect plasma levels of amino acids in conscious and freely moving rats. The icv infusion of L-serine significantly decreased the plasma levels of glycine, glutamate, and Dserine, but not glutamine and L-serine. Furthermore, the icv infusion of D-serine significantly decreased the plasma levels of glycine, glutamate, and L-serine, but not glutamine. Expectedly, a marked increase of plasma D-serine was detected after icv infusion of D-serine. These findings suggest that the metabolic pathway for L-and D-serine may be markedly different in the rat brain.

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Measurement of daphnoretin in plasma of freely moving rat by liquid chromatography

Cited by 24 publications

References 11 publications

In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

Chemical constituents and biological activities from roots ofEnkleia siamensis

Alterations in Plasma Levels of Amino Acids after Intracerebroventricular Administration of L-Serine or D-Serine in Conscious and Freely Moving Rats

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