Measurement of endogenous allergens in genetically modified soybeans – Short communication

Ladics, Gregory S.; Budziszewski, Gregory J.; Herman, Rod A.; Hérouet-Guicheney, Corinne; Joshi, Saurabh S.; Lipscomb, Elizabeth A.; McClain, Scott; Ward, Jason

doi:10.1016/j.yrtph.2014.06.006

Cited by 30 publications

(22 citation statements)

References 50 publications

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“…In contrast, "other scientists", such as Ladics et al (2014), and the co-authors of OECD consensus documents, not only do not recommend compositional analysis data, but they do not recommend ANY measurement of endogenous allergen levels for even allergenic foods, like soybean (OECD, 2012). 2.…”

Section: Outcome Of Public Consultation On the Draft Guidance On Allementioning

confidence: 99%

“…• Lines 565-567 of the GD mentions that EFSA "and other scientists" recommend inclusion of allergens in the comparative compositional analysis -but all of the references in the GD are from EFSA scientists. In contrast, "other scientists", such as Ladics et al (2014), and the co-authors of OECD consensus documents, not only do not recommend compositional analysis data, but they do not recommend ANY measurement of endogenous allergen levels for even allergenic foods, like soybean (OECD, 2012). 2.…”

Section: Outcome Of Public Consultation On the Draft Guidance On Allementioning

confidence: 99%

“…a reference peer-reviewed article) can be used for every application for few years. We would recommend that the list of relevant soybean allergens and the rationale provided in Ladics et al (2014) should be acceptable as such or as a starting point for building an updated list of allergens. We therefore request that the Lines 610 and 621 and Annex C-2 are amended in line with this.…”

Section: Outcome Of Public Consultation On the Draft Guidance On Allementioning

confidence: 99%

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Outcome of the public consultation on the draft guidance on allergenicity assessment of genetically modified plants

2017

EFSA Supporting Publications

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The European Food Safety Authority (EFSA) carried out a public consultation to collect input from the scientific community and all interested parties on the draft guidance on allergenicity assessment of genetically modified plants. The draft guidance document was prepared by the Allergenicity Working Group of the EFSA Panel on Genetically Modified Organisms (GMO Panel) and endorsed by the Panel for public consultation at its plenary meeting on 26 July 2016. EFSA received approximately 200 comments on the draft guidance from 25 interested parties. As part of EFSA's public consultation, an EFSA workshop at an initial stage of the process as well as an EFSA info session meeting were held in Brussels on 17 June 2015 and in Parma on 23 rd November 2016, respectively. In addition, a pilot "Focus group" project involving several stakeholder groups closely followed the development of the document during its entire lifetime. The current report summarises the outcome of the public consultation, and includes a brief description of the comments received and how the comments were addressed. EFSA and its GMO Panel wish to thank all stakeholders and the general public for their contributions. The GMO Panel prepared an updated version of the guidance taking into account the comments received. The guidance document was adopted at the GMO Plenary meeting on 18 May 2017, and is published in the EFSA Journal.

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Section: Outcome Of Public Consultation On the Draft Guidance On Allementioning

confidence: 99%

Section: Outcome Of Public Consultation On the Draft Guidance On Allementioning

confidence: 99%

Section: Outcome Of Public Consultation On the Draft Guidance On Allementioning

confidence: 99%

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Outcome of the public consultation on the draft guidance on allergenicity assessment of genetically modified plants

2017

EFSA Supporting Publications

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“…There was a research study examining allergens from endogenous soybeans based off of allergen databases and peerreviewed publications [11] . This study evaluated 15 different possible soybean allergens, eight of which had enough clinical data to confirm as allergens [11] . The results of this study should be used to understand what the composition for new soybean varieties should be [11] .…”

Section: Review Of Literaturementioning

confidence: 99%

“…This study evaluated 15 different possible soybean allergens, eight of which had enough clinical data to confirm as allergens [11] . The results of this study should be used to understand what the composition for new soybean varieties should be [11] . It is apparent that genetically modifying soy can get rid of allergens present within soy.…”

Section: Review Of Literaturementioning

confidence: 99%

Prevalence of Soy Allergies and Use of Genetically Modified Soy

Teramoto¹

2015

IJFNS

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There is a growing trend of both genetically modified food consumption within the U.S. population and increasing food allergies among children in the U.S. This paper discusses whether a correlation exists between the number of children in the U.S. who have developed soy allergies and the increased use of genetically modified soy over time. Genetic modification and food allergies may be linked to each other, as certain proteins introduced to genetically modified food may lead to allergic or toxic reaction in some people. During the past 20 years, the use of genetically modified food has increased significantly. It can be assumed that children are experiencing more food allergies because their immune systems are still immature. They are being exposed to foods that may cause allergies, such as soy, at an earlier age because it is in staple foods, such as baby food, breads, baking mixes, crackers, breakfast cereals, canned broths, low fat peanut butter, and more. Soy allergies are many times outgrown in children, as determined through periodic skin prick tests. However, studying a possible correlation between soy allergies and increased use of genetically modified soy is important clinically, so that children can be accurately diagnosed and symptoms can be relieved as early as possible. Further research needs to be done to analyze whether the cross of genes from proteins introduced to genetically modified food creates a significant increase in soy allergies within children.

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Metabolic changes in transgenic maize mature seeds over-expressing the Aspergillus niger phyA2

et al. 2015

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Non-targeted metabolomics analysis revealed only intended metabolic changes in transgenic maize over-expressing the Aspergillus niger phyA2. Genetically modified (GM) crops account for a large proportion of modern agriculture worldwide, raising increasingly the public concerns of safety. Generally, according to substantial equivalence principle, if a GM crop is demonstrated to be equivalently safe to its conventional species, it is supposed to be safe. In this study, taking the advantage of an established non-target metabolomic profiling platform based on the combination of UPLC-MS/MS with GC-MS, we compared the mature seed metabolic changes in transgenic maize over-expressing the Aspergillus niger phyA2 with its non-transgenic counterpart and other 14 conventional maize lines. In total, levels of nine out of identified 210 metabolites were significantly changed in transgenic maize as compared with its non-transgenic counterpart, and the number of significantly altered metabolites was reduced to only four when the natural variations were taken into consideration. Notably, those four metabolites were all associated with targeted engineering pathway. Our results indicated that although both intended and non-intended metabolic changes occurred in the mature seeds of this GM maize event, only intended metabolic pathway was found to be out of the range of the natural metabolic variation in the metabolome of the transgenic maize. Therefore, only when natural metabolic variation was taken into account, could non-targeted metabolomics provide reliable objective compositional substantial equivalence analysis on GM crops.

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Measurement of endogenous allergens in genetically modified soybeans – Short communication

Cited by 30 publications

References 50 publications

Outcome of the public consultation on the draft guidance on allergenicity assessment of genetically modified plants

Outcome of the public consultation on the draft guidance on allergenicity assessment of genetically modified plants

Prevalence of Soy Allergies and Use of Genetically Modified Soy

Metabolic changes in transgenic maize mature seeds over-expressing the Aspergillus niger phyA2

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