Measurement of estradiol-induced wheel running with brief time samples

King, James M.; Cox, Verne C.

doi:10.3758/bf03337071

Cited by 2 publications

(2 citation statements)

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“…Daily sc .1-ml injections of 3.0 Mg of estradiol benzoate (EB) or oil were begun on Day 3 following surgery and were continued for the duration of the experiment. This dosage has been shown to be effective in influencing body weight (King & Cox, 1973) and activity (King & Cox, 1976) in rats. Following the recovery period, data on activity and body weight were collected for 15 days.…”

Section: Methodsmentioning

confidence: 99%

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Effects of lesions of the amygdala, preoptic area, and hypothalamus on estradiol-induced activity in the female rat.

King

1979

Journal of Comparative and Physiological Psychology

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Lesions of the anterior hypothalamic nucleus and the medial preoptic area sharply attenuated enhancement of wheel running by estradiol benzoate in ovariectomized female rats. Lesions of the corticomedial amygdala had no effect on this behavior. The hormonal effects on activity were largely independent of any changes in body weight. Results of this first experiment indicated that the anterior hypothalamic and medial preoptic areas are critically involved in the induction of activity by estradiol. However, this experiment provided no support for suggestions that the corticomedial amygdala inhibits those structures that mediate the estrogenic induction of activity. In the second experiment, food deprivation was used to stimulate activity. Results of this experiment suggested that the reduction in the ability of estradiol to induce activity following anterior hypothalamic and medial preoptic lesions does not reflect a general inability to become more active.In the female rat, elevated estrogen levels are associated with reduced food intake and body weight (King & Cox, 1973), enhanced sexual receptivity (Pfaff, 1970), and increased locomotor activity (Finger, 1969). It has been reported that estradiol implanted in or near the medial preoptic area (MP) enhanced locomotor activity in ovariectomized rats (Wade & Zucker, 1970), whereas an implant in the anterior hypothalamic area (AH) was without effect on activity (Wade & Zucker, 1970). Colvin and Sawyer (1969) noted that wheel running in ovariectomized rats was stimulated not only by estrogen implants in and around the AH but also by implants in posterior hypothalamic areas. Colvin and Sawyer obtained equivocal results with their MP placements, however. This report is based on a dissertation submitted to the graduate faculty of the University of Texas at Arlington in partial fulfillment of the requirements for the PhD degree. The assistance of the members of the dissertation committee (

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Section: Methodsmentioning

confidence: 99%

“…Each rat was run in the same wheel throughout the experiment. The effectiveness of this activity-measuring procedure has been demonstrated with both endogenous (Hitt, Gerall, & Giantonio, 1968) and exogenous (King & Cox, 1976) estrogens. The experimental room was illuminated with a 25-W red light during data collection periods.…”

Section: Methodsmentioning

confidence: 99%