Measurement of flow-physiologic parameters of retinal blood circulation in type 1 and 2 diabetics before and after photocoagulation

Oswald, B; Vilser, Walthard; Oswald, Hanno; Jütte, A; Schweitzer, Dietrich; Königsdörffer, E.; Deufrains, A; Dietze, U.

doi:10.1007/bf02148892

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…The results, however, have been somewhat contradictory: Compared to healthy control groups, elevated [17,18,28,36], reduced [4][5][6], or unchanged [13,15,16,20] flow values were found in diabetics with no or non-proliferative retinopathy. In proliferative retinopathy, however, laser treatment reduces retinal blood flow [14,19,27,28]. This may reflect either a reduced oxygen demand by the coagulated tissue, or an increase of oxygen diffusion from the choroid to the inner retina, or both [37].…”

Section: Introductionmentioning

confidence: 95%

Diabetic patients with retinopathy show increased retinal venous oxygen saturation

Hammer

Vilser²,

Riemer³

et al. 2009

Graefes Arch Clin Exp Ophthalmol

167

198

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The increase of retinal vessel oxygen saturation in diabetic retinopathy points to a diabetic microvascular alteration. This may be due to occlusions and obliterations in the capillary bead and the formation of arterio-venous shunt vessels. On the other hand, hyperglycaemia-induced endothelial dysfunction, with subsequent suppression of the endothelial NO-synthase and disturbance of the vascular auto-regulation, may contribute to retinal tissue hypoxia.

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Section: Introductionmentioning

confidence: 95%

Diabetic patients with retinopathy show increased retinal venous oxygen saturation

Hammer

Vilser²,

Riemer³

et al. 2009

Graefes Arch Clin Exp Ophthalmol

167

198

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“…A corresponding decrease, as in retinal venular oxygen saturation, was observed in retinal venular diameter in the 'light' laser group (Group 1). Previous studies have shown that blood flow in the retinal vessels is reduced after PRP (Oswald et al 1985;Fujio et al 1994). The decrease in diameter in this group could indicate reduced blood flow as an expression of less oxygen demand by the tissue.…”

Section: Discussionmentioning

confidence: 54%

Retinal vascular oxygen saturation in response to a less extensive laser treatment in proliferative diabetic retinopathy

Vergmann

Torp

Kawasaki

et al. 2020

Acta Ophthalmologica

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The purpose of this study was to evaluate the association between retinal laser burden and vascular oxygen saturation in patients with proliferative diabetic retinopathy (PDR) treated with different extent of retinal laser. Methods: The study was a prospective, interventional study of patients with treatment-na€ ıve PDR. Patients were treated with navigated retinal laser (Navilas â , OD-OS GmbH, Teltow, Germany) in different doses. Retinal oximetry was obtained at baseline (BL) prior to laser and after 6 months (M6). Patients were divided into three groups according to total laser spots applied: <1500 spots (Group 1), 1500-2000 spots (Group 2), and >2000 spots (Group 3). Results: We included 33 eyes of 28 patients with treatment-na€ ıve PDR. The groups did not differ according in BL characteristics. Between BL and M6, retinal arteriolar oxygen saturation did not change but retinal venular oxygen saturation (median with interquartile range) decreased in Groups 1 and 2 (1: 65.5 AE 8.8% versus 60.5 AE 9.5%, p = 0.04; 2: 65.3 AE 7.3% versus 63.0 AE 13.5%, p = 0.04). Focal retinal venular oxygen saturation, located to quadrants with retinal neovascularization, decreased in Group 2 from BL to M6 (67.5 AE 13.3% versus 61.5 AE 8.8%, p = 0.04). Retinal venular diameter decreased from BL to M6 in Group 1 (174.5 AE 15.3 lm versus 165.1 AE 28.7 lm, p = 0.01). Conclusions: In this study of patients with treatment-na€ ıve PDR, we showed that a less extensive laser treatment caused a reduction in retinal venular oxygen saturation and diameter 6 months after treatment. Our results suggest that less extensive laser treatment may be sufficient to improve the retinal metabolic environment conducive to PDR regression.

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“…Dabei wurde bei Zentralvenenthrombosen an temporal oberen Qua dranten und bei .Astvenenthrombose im be troffenen Netzhautquadranten gemessen. Die bereits veröffentlichten Ergebnisse lassen zusammengefasst folgende Schlussfolgerun gen zu [Vilser et al, 1985] …”

Section: Fotokoagulation Bei Venösen Verschlusserkrankungenunclassified

“…dass bisher trotz guter Beispiele die the rapeutische Wirksamkeit der Folokoagulalion bei venösen Verschlusscrkrankungcn kli nisch nicht eindeutig nachgewiesen werden kann. Zum Einfluss der Fotokoagulation auf die Strömungsverhältnisse der Netzhaut bei venösen Verschlusserkrankungen gibt es nur wenige klinisch-experimentelle Untersu chungen mit direkten Durchblutungsmessun gen [Brandt et al, 1981;Vilser et al 1985], abgesehen von indirekten aus dem klinischen Bild abgeleiteten Hinweisen auf Veränderun gen der Netzhautdurchblutung. Ebenso un klar wie bei der diabetischen Retinopathie ist auch bei venösen Verschlusscrkrankungcn der therapeutische Wirkmechanismus der Fotokoagulation.…”

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Klinische Interpretation retinaler Durchblutungsmessungen

Vilser¹,

Deufrains²,

Dietze³

et al. 1986

Ophthalmologica

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Based on the pathomechanism of diabetic retinopathy, the effect of photocoagulation on retinal microcirculation as assessed by measurements of retinal microcirculation magnitudes is discussed. The clinico-experimental results support the opinion that an essential effect of photocoagulation is due to an improvement in the flow conditions of the noncoagulated central retinal area with regard to metabolic exchange and stasis situation by the coagulation-induced occlusion of peripheral capillary areas. Further clinico-experimental measurements of retinal microcirculation magnitudes for the assessment of the behavior of microcirculation after photocoagulation in venous occlusive diseases of the retina are presented. It is shown that retinal microcirculation immediately after photocoagulation reacts by transitory instationary flow conditions; in this period it is quite possible that an additional blood flow reduction over several days will occur. In particular, the effect of photocoagulation in venous occlusive diseases with narrow arterial vessels is discussed. It is emphasized that with regard to the therapeutic effect of photocoagulation as well as to the discussion of pathomechanisms, apart from blood flow, the differentiated behavior of single retinal vascular areas, such as arteries, arterioles, capillaries, venules and veins, requires more attention. Particularly with this in mind, substantial improvements in differential diagnosis and treatment of retinal circulatory disturbances may be expected from measurements of retinal circulation magnitudes.

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Measurement of flow-physiologic parameters of retinal blood circulation in type 1 and 2 diabetics before and after photocoagulation

Cited by 16 publications

References 7 publications

Diabetic patients with retinopathy show increased retinal venous oxygen saturation

Diabetic patients with retinopathy show increased retinal venous oxygen saturation

Retinal vascular oxygen saturation in response to a less extensive laser treatment in proliferative diabetic retinopathy

Klinische Interpretation retinaler Durchblutungsmessungen

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