Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

Olausson, Eva A.; Brock, Christina; Drewes, Asbjørn Mohr; Grundin, Håkan; Isaksson, Mats; Stotzer, Per-Ove; Abrahamsson, Hasse; Attvall, Stig; Simrén, Magnus

doi:10.1111/nmo.12075

Cited by 36 publications

(28 citation statements)

References 47 publications

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“…In line with this complex pathophysiology, the association between upper GI symptoms and gastric emptying is modest. Conversely, gastric emptying rate cannot explain the range of upper GI symptoms experienced, neither in DM patients nor in the case of idiopathic gastroparesis [11–14]. …”

Section: Introductionmentioning

confidence: 99%

Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis

Søfteland

Brock

Frøkjær

et al. 2014

Journal of Diabetes Research

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In a clinical setting, diabetic autonomic complications (cardiac, gastrointestinal, urogenital, etc.) are often handled as separate entities. We investigated rectal sensitivity to heat, mechanical distension, and electrical stimulations in 20 patients with diabetes and symptoms of gastroparesis, to evaluate the extent of visceral neuronal damage. Furthermore, to evaluate the relation between the nervous structures we examined gastric emptying and cardiac autonomic function with the hypothesis being an association between these. We found that 60% of patients had delayed gastric empting. Rectal hyposensitivity was a general finding as they tolerated 67% higher thermal, 42% more mechanical, and 33% higher electrical current intensity compared to healthy controls. In patients, most heart rate variability parameters were reduced; they reported significantly more gastrointestinal symptoms and a reduced quality of life in all SF-36 domains. Shortened RR interval correlated with reduced rectal temperature sensitivity, and gastric retention rate was negatively associated with symptoms of nausea and vomiting. To conclude, in these patients with signs and symptoms of diabetic gastroparesis, rectal sensitivity was reduced, and heart rate variability was impaired. Thus, we suggest regarding diabetic autonomic neuropathy as a diffuse disorder. Symptoms of widespread autonomic dysfunction and sensory disorders should be expected and treated in these patients.

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Section: Introductionmentioning

confidence: 99%

Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis

Søfteland

Brock

Frøkjær

et al. 2014

Journal of Diabetes Research

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“…Ron et al found that early satiety was the only patient-reported symptom associated with delayed gastric emptying, as assessed by breath-test [21]. Prospective studies using validated scoring systems have correlated protean symptoms with gastric retention; however, a wide variability exists [11–13, 16]. In fact, delayed gastric emptying rate (GER) is not always associated with symptoms.…”

Section: Discussionmentioning

confidence: 99%

Vomiting and Dysphagia Predict Delayed Gastric Emptying in Diabetic and Nondiabetic Subjects

Boltin

Zvidi

Steinmetz

et al. 2014

Journal of Diabetes Research

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Background. Gastroparesis is a heterogeneous disorder most often idiopathic, diabetic, or postsurgical in nature. The demographic and clinical predictors of gastroparesis in Israeli patients are poorly defined. Methods. During the study period we identified all adult patients who were referred to gastric emptying scintigraphy (GES) for the evaluation of dyspeptic symptoms. Of those, 193 patients who were referred to GES from our institution were retrospectively identified (76 (39%) males, mean age 60.2 ± 15.6 years). Subjects were grouped according to gastric half-emptying times (gastric T 1/2). Demographic and clinical data were extracted from electronic medical records or by a phone interview. Key Results. Gastric emptying half-times were normal (gastric T 1/2 0–99 min) in 101 patients, abnormal (gastric T 1/2 100–299 min) in 67 patients, and grossly abnormal (gastric T 1/2 ≥ 300 min) in 25 patients. Vomiting and dysphagia, but neither early satiety nor bloating, correlated with delayed gastric emptying. Diabetes was associated with grossly abnormal gastric T 1/2. Idiopathic gastroparesis was associated with a younger age at GES. No correlation was observed between gastric T 1/2 values and gender, smoking, H. pylori infection, HBA1C, or microvascular complication of diabetes. Conclusions Inferences. Vomiting and dysphagia are predictive of delayed gastric emptying in both diabetic and nondiabetic subjects. Diabetes is associated with more severe gastroparesis.

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“…10 It is a non-invasive and quantitative method, but the measurement is rough and disconnected. 3 A magnetic capsule endoscopy may provide continuous visual gastric motility and qualitative aspects of the motility. This report is the first step to develop the novel technique for intra-gastric monitoring of the gastric motility, although there are lots of problems to be solved: the validation should be performed; the quantitative measurement of gastric motility for determining normal motility should be further investigated also; and the cost-effectiveness should be evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Scintigraphy using radionuclide luminescence imaging provides visual movement of the stomach, such as gastric emptying, that is rough and disconnected. 3 These 2 techniques represent indirect images of gastric motility. Wireless capsule endoscopy is mainly used for identifying small bowel diseases.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Trial of Ambulatory Monitoring of Gastric Motility Using a Modified Magnetic Capsule Endoscope

Kim

Choi

Cho

2014

J Neurogastroenterol Motil

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The magnetic capsule endoscope has been modified to be fixed inside the stomach and to monitor the gastric motility. This pilot trial was designed to investigate the feasibility of the magnetic capsule endoscope for monitoring gastric motility. The magnetic capsule endoscope was swallowed by the healthy volunteer and maneuvered by the external magnet on his abdomen surface inside the stomach. The magnetic capsule endoscope transmitted image of gastric peristalsis. This simple trial suggested that the real-time ambulatory monitoring of gastric motility should be feasible by using the magnetic capsule endoscope.

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Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

Cited by 36 publications

References 47 publications

Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis

Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis

Vomiting and Dysphagia Predict Delayed Gastric Emptying in Diabetic and Nondiabetic Subjects

A Pilot Trial of Ambulatory Monitoring of Gastric Motility Using a Modified Magnetic Capsule Endoscope

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