Measurement of Gastrointestinal Transit

Lin, Henry C.; Prather, Charlene M.; Fisher, Robert S.; Meyer, James H.; Summers, Robert W.; Pimentel, Mark; McCallum, Richard W.; Akkermans, L.M.A.; Loening‐Baucke, Vera

doi:10.1007/s10620-005-2694-6

Cited by 142 publications

(96 citation statements)

References 71 publications

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“…The accuracy of the temperature sensor is AE0. 5 C, pH sensor AE0.5 pH units, and pressure AE5 mmHg below 100 mmHg. 7 In contrast to the WMC, the WCE encompasses a miniature, encapsulated video camera designed to image the entire small bowel, taking approximately 50,000-60,000 digital images per study.…”

Section: Wireless Motility Capsulementioning

confidence: 99%

Gastrointestinal motility revisited: The wireless motility capsule

2013

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Introduction: The wireless motility capsule (WMC) is a novel ambulatory technology that concurrently measures intraluminal pH, temperature, and pressure as it traverses the gastrointestinal tract. Objectives: We aim to provide a concise summary of the WMC, detailing the procedure for its administration and the parameters it records. We also review the evidence that has validated the WMC against other methods currently regarded as 'gold standard'. Conclusions: The WMC offers a number of advantages over and above current techniques, especially with respect to patient tolerability, safety, and standardization. The WMC represents a considerable enhancement of the researchers' and clinicians' investigatory armamentarium. If this technology becomes widely adopted, coupled with international consensus upon the interpretation of physiological data derived therein, it may herald a new and exciting era in gastrointestinal physiology.

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Section: Wireless Motility Capsulementioning

confidence: 99%

Gastrointestinal motility revisited: The wireless motility capsule

2013

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“…1 However, gastric emptying values are dependent on various factors such as meal composition and consistency, 2 body position, 3 smoking, 4 gender, 5 phase of menstrual cycle 6 and time of day the study is performed. 7 Therefore, study protocol standardization and established normal values for such protocol are needed for accurate interpretation of the test.…”

Section: Introductionmentioning

confidence: 99%

Normal Solid Gastric Emptying Values Measured by Scintigraphy Using Asian-style Meal:A Multicenter Study in Healthy Volunteers

Vasavid

Chaiwatanarat

Pusuwan

et al. 2014

J Neurogastroenterol Motil

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Background/AimsTo report gastric emptying scintigraphy, normal values should be established for a specific protocol. The aim of this study was to provide normal gastric emptying values and determine factors affecting gastric emptying using Asian rice-based meal in healthy volunteers. 372Methods One hundred and ninety-two healthy volunteers were included at 7 tertiary care centers across Thailand. Gastric emptying scintigraphy was acquired in 45 degree left anterior oblique view immediately after ingestion of a 267 kcal steamed-rice with technetium-99m labeled-microwaved egg meal with 100 mL water for up to 4 hours. ResultsOne hundred and eighty-nine volunteers (99 females, age 43 ± 14 years) completed the study. The medians (5-95th percentiles) of lag time, gastric emptying half time (GE T1/2) and percent gastric retentions at 2 and 4 hours for all volunteers were 18.6 (0.

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“…In clinical practice, colon transit is most usually measured using the radio-opaque marker technique [Lin et al 2005]. This approach has been shown to provide an accurate and reproducible assessment of overall colonic transit and by examining the distribution of retained markers may give some hints as to whether the underlying problem is colonic inertia or defaecatory dysfunction.…”

Section: Ibs-u (Unclassified)mentioning

confidence: 99%

Prucalopride: safety, efficacy and potential applications

Quigley

2011

Therap Adv Gastroenterol

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Chronic constipation is a very common functional gastrointestinal disorder which can be associated with significant impairments in quality of life for some people with the condition. Its management has, traditionally, been based on dietary and lifestyle changes and the use of a variety of laxative agents. The evidence base for the efficacy of the latter is, in many cases, slim. Not surprisingly, many patients remain dissatisfied with laxatives thus leading to the development of more pharmacological approaches. Among these approaches is the use of prokinetic agents; while prior molecules have been troubled by lack of selectivity and cardiac side effects, the new agent, prucalopride, appears to be highly selective for the serotonin 5-HT4 receptor and is, therefore, a potent stimulator of gut motility. In three large pivotal randomized controlled trials, prucalopride has been effective in relieving the cardinal symptoms of chronic constipation; these effects have been sustained in open-label follow up for as long as 18 months. The safety profile has been encouraging and, especially so, the absence of arrhythmogenic potential. Studies in men, in constipation-predominant irritable bowel syndrome and in other motor disorders are eagerly awaited.

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Measurement of Gastrointestinal Transit

Cited by 142 publications

References 71 publications

Gastrointestinal motility revisited: The wireless motility capsule

Gastrointestinal motility revisited: The wireless motility capsule

Normal Solid Gastric Emptying Values Measured by Scintigraphy Using Asian-style Meal:A Multicenter Study in Healthy Volunteers

Prucalopride: safety, efficacy and potential applications

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