Measurement of gold and sulfur mass fractions in l-cysteine-modified gold nanoparticles by ICP-DRC-MS after acid digestion: validation and uncertainty of results

Ji, Wei; Hibbert, David Brynn; Moran, Grainne; Akter, Rabeya

doi:10.1039/c2ja30103b

Cited by 17 publications

(9 citation statements)

References 36 publications

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“…In accordance to the work of Jiang et al . 44 ICP–MS application for simultaneous measurement of gold and sulfur was found herein to be robust with relative standard uncertainties lower than 10% (for more information see Supporting Information). …”

Section: Resultsmentioning

confidence: 80%

Quantifying Thiol Ligand Density of Self-Assembled Monolayers on Gold Nanoparticles by Inductively Coupled Plasma–Mass Spectrometry

et al. 2013

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Gold nanoparticles (GNPs) are often used as colloidal carriers in numerous applications owing to their low-cost and size-controlled preparation as well as their straightforward surface functionalization with thiol containing molecules forming self-assembling monolayers (SAM). The quantification of the ligand density of such modified GNPs is technically challenging, yet of utmost importance for quality control in many applications. In this contribution, a new method for the determination of the surface coverage of GNPs with thiol containing ligands is proposed. It makes use of the measurement of the gold-to-sulfur (Au/S) ratio by inductively coupled plasma mass spectrometry (ICP–MS) and its dependence on the nanoparticle diameter. The simultaneous ICP–MS measurement of gold and sulfur was carefully validated and found to be a robust method with a relative standard uncertainty of lower than 10%. A major advantage of this method is the independence from sample preparation; for example, sample loss during the washing steps is not affecting the results. To demonstrate the utility of the straightforward method, GNPs of different diameters were synthesized and derivatized on the surface with bifunctional (lipophilic) ω-mercapto-alkanoic acids and (hydrophilic) mercapto-poly(ethylene glycol) (PEG)n-carboxylic acids, respectively, by self-assembling monolayer (SAM) formation. Thereby, a size-independent but ligand-chain length-dependent ligand density was found. The surface coverage increases from 4.3 to 6.3 molecules nm–2 with a decrease of ligand chain length from 3.52 to 0.68 nm. Furthermore, no significant difference between the surface coverage of hydrophilic and lipophilic ligands with approximately the same ligand length was found, indicating that sterical hindrance is of more importance than, for example, intermolecular strand interactions of Van der Waals forces as claimed in other studies.

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Section: Resultsmentioning

confidence: 80%

Quantifying Thiol Ligand Density of Self-Assembled Monolayers on Gold Nanoparticles by Inductively Coupled Plasma–Mass Spectrometry

et al. 2013

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“…Here, again the EDS spectrum of S0 is compared with spectrum of L-cysteine for which binding energy peak of S is at~2 keV, is shown in supplementary information ( Figure S1 (b)). The most intense binding energy peak for Au in S0 is also obtained at~2 keV, thus the peak of S from Lcysteine could be merged together with the binding energy peak of Au which is also evident from the literature [61]. Fig.…”

Section: Spectroscopic Analysismentioning

confidence: 76%

Biologically active l-cysteine as a reducing/capping agent for controlled tuning of gold nanoparticles

Sharma

Rabinal

2015

Journal of Alloys and Compounds

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“…Jiang et al 190 determined Au and S in acid digests of L-cysteine modied gold nanoparticles. Polyatomic interferences arising from O 2 on the 32 S isotope during ICP-MS analysis were circumvented by the addition of further oxygen and then measuring the SO molecular species at m/z 48.…”

Section: +mentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

Carter

Clough

Fisher

et al. 2020

J. Anal. At. Spectrom.

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Measurement of gold and sulfur mass fractions in l-cysteine-modified gold nanoparticles by ICP-DRC-MS after acid digestion: validation and uncertainty of results

Cited by 17 publications

References 36 publications

Quantifying Thiol Ligand Density of Self-Assembled Monolayers on Gold Nanoparticles by Inductively Coupled Plasma–Mass Spectrometry

Quantifying Thiol Ligand Density of Self-Assembled Monolayers on Gold Nanoparticles by Inductively Coupled Plasma–Mass Spectrometry

Biologically active l-cysteine as a reducing/capping agent for controlled tuning of gold nanoparticles

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

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