Measurement of Hemodynamics During Postural Changes Using a New Wearable Cephalic Laser Blood Flowmeter

Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow

“…Paste-on, single-point sensors have some potential to reduce the effects of movement but likely not to levels that would allow use during normal body motions. Wearable optical measurement systems are becoming available (16)(17)(18)(19), but present hardware involves rigid, bulky device components that are affixed to the skin in ways that can lead to irritation and discomfort after prolonged application, to pressure on the microcirculatory bed that can cause erroneous readings.…”

Potassium Channels and Neurovascular Coupling

“…In the normally functioning brain, increases in neuronal activity are accompanied by rapid, spatially localized increases in blood flow that serve to avoid the development of ischemic conditions in active regions of the brain. 2–6 This coupling of increased neuronal activity to increased local cerebral blood flow (CBF), a process known as functional hyperemia or neurovascular coupling (NVC), occurs as a result of vasodilation at the level of the cerebral microcirculation and appears to depend on the generation of vasoactive substances. 1 Abnormalities associated with cerebral microcirculatory function have been associated with a number of disorders, including Parkinson’s disease, stroke, and migraine.…”