Measurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys

Principles of Safety Pharmacology

“…Martel et al (2013) also compared HDO to a DSI implanted system and challenged blood pressure pharmacologically to reach hypotensive and hypertensive situations. Similar statements were given by Bramlage et al (2009) for the common marmoset and Niehoff et al (2014) for the cynomolgus monkey. 5) and for DAP 0.81 AE 0.02.…”

Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study

“…The animal that had removal surgery was exposed to new materials in a single low volume, and no particular unusual findings were observed in the general symptoms and feed collection observations prior to the sensor removal operation. The fibrous substance observed in the animal may be a protective mechanism elicited by the body against external materials [ 5 ]. This was considered as a complex wound healing response to the presence of biomedical device with diverse cell signaling, followed by migration of fibroblasts to the implant surface.…”

Cardiovascular safety risk assessment for new candidate drugs from functional and pathological data: Conference report

“…One method that achieves this in the same individual animals is the use of minimally invasive telemetric blood pressure monitoring (MITBP) in nonrodent species in repeat-dose toxicology studies (McMahon, Mitchell, Klein, Jenkins, & Sarazan, 2010;Niehoff, Niggemann, Sternberg, Jenkins, & Holbrook, 2014). This requires minimal, superficial surgery to implant a radiotelemetry transmitter originally designed for use in mice, into a dog or monkey.…”