Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease

Brúgós, Boglárka; Kiss, Emese; Dul, Csaba; Gubisch, Wolfgang; Szegedi, Gyula; Sipka, Sándor; Zeher, Margit

doi:10.1016/j.humimm.2010.06.004

Cited by 21 publications

(10 citation statements)

References 25 publications

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“…Furthermore, Migita et al [93] observed correlations between serum resistin and CRP, ESR and TNFα in patients with RA, which is consistent with earlier findings by Schaffler et al [71] and a recent report by Forsblad d’Elia et al [94]. This study also revealed a strong positive correlation between resistin and IL-1 receptor antagonist, the serum level of which is elevated in many rheumatic diseases [95], whereas bone mineral density was inversely correlated with serum resistin. The fact that in humans resistin levels positively correlated with coronary atherosclerosis occurrence may suggest a role of resistin in the inflammation-based etiology of atherosclerosis in RA [94].…”

Section: Resultssupporting

confidence: 89%

The role of adipokines in connective tissue diseases

2012

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ObjectiveTo discuss the relationship between adipokines and connective tissue diseases, by putting special emphasis on the potential role of leptin, adiponectin, resistin, and other adipose tissue products in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus and on possible application of adipokine-targeted therapy in the treatment of these disorders with emphasis on the recent findings.MethodsPubMed literature search complemented by review of bibliographies listed in identified articles.ResultsMost of the data presented by different research groups showed changed levels of leptin, adiponectin, and resistin and occasionally also other adpokines in rheumatoid arthritis and systemic lupus erythematosus. The relationship between the remaining connective tissue diseases and adipokines is less documented.ConclusionsPlasma levels of adipokines might tell us too little about their role in connective tissue disorders, whereas adipokine effects on synovial tissues might differ from their known metabolic or cardiovascular effects, which implies that some re-appraisal of adipokines role may need to take place. It still remains obscure whether the observed disturbances in various adipokine systems in subjects with connective tissue diseases contribute to their development or only reflect the presence or activity of inflammatory process, which itself is induced by other pro-inflammatory factors.

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Section: Resultssupporting

confidence: 89%

The role of adipokines in connective tissue diseases

2012

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“…For example, we recently noted that the proinflammatory cytokine BAFF was likewise detectable in a minority of SLE patients, despite clear evidence of its association with disease . Others also observed associations of serum IL‐1Ra with SLE disease activity only in a subset of patients with inactive lupus nephritis, even though this patient subset did not have the highest overall disease activity .…”

Section: Discussionmentioning

confidence: 94%

Brief Report: Interleukin‐38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus

Rudloff

Godsell

Nold-Petry

et al. 2015

Arthritis & Rheumatology

108

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“…[223][224][225][226] Affected individuals with high levels of IL-1-RA tend to be at a lower risk of developing lupus nephritis compared with those possessing normal IL-1-RA levels. 227 In addition, certain NALP1 SNPs have been associated with susceptibility to the dermatitis, arthritis, and nephritis of SLE. 228 The response of musculoskeletal and joint symptoms to anakinra, albeit transient, warrants further investigation into the potential of IL-1 blockade therapy.…”

Section: Autoinflammation In Common Skin Diseasesmentioning

confidence: 99%

Autoinflammation: From monogenic syndromes to common skin diseases

Nguyen

Cowen

Leslie

2013

Journal of the American Academy of Dermatology

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Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the interleukin 1 beta (IL-1ß)-processing inflammasome complex have been found in several rare autoinflammatory syndromes, for which anticytokine therapy such as IL-1 or tumor necrosis factor-alfa inhibition may be effective. It is becoming clear that features of autoinflammation also affect common dermatoses, some of which were previously thought to be solely autoimmune in origin (eg, vitiligo, systemic lupus erythematosus). Recognizing the pathogenetic role of autoinflammation can open up new avenues for the targeted treatment of complex, inflammatory dermatoses.

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Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease

Cited by 21 publications

References 25 publications

The role of adipokines in connective tissue diseases

The role of adipokines in connective tissue diseases

Brief Report: Interleukin‐38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus

Autoinflammation: From monogenic syndromes to common skin diseases

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