Measurement of Intra-Vaginal and Intra-Uterine Pressures During Human Coitus by Radio-Telemetry

Fox, C. A.; Wolff, H.S.; Baker, Julie

doi:10.1530/jrf.0.0220243

Cited by 129 publications

(63 citation statements)

References 5 publications

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“…Movements of the ciliae within the oviduct seems also to be an very unlikely candidate, since the beat of ciliae is directed from the ampulla to the uterus in the opposite direction; in addition, the observation that women with Kartagener syndrome (congenital absence of ciliae), have no difficult in becoming pregnant (Amsler and Pavic, 1985;McComb et al, 1986;Halbert et al, 1997) argues against the beat of ciliae as a major factor in rapid transport. Capillary forces generated within the mucus and a difference in hydrostatic pressure between the vagina and the peritoneal cavity have been described (Fox et al, 1970); it is, however, unlikely that these factors account for the immediate uptake from the vagina and the directed transport. Therefore, peristaltic contractions of the uterus and of the muscular layers of the Fallopian tubes represent the most likely candidates responsible for the rapid transport phenomena.…”

Section: Normal and Disturbed Function Of The Uterus And Fallopian Tubesmentioning

confidence: 99%

Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography

Wildt

Kissler²,

Licht³

et al. 1998

Human Reproduction Update

139

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The transport function of the uterus and oviducts and its modulation by oxytocin has been examined using hysterosalpingoscintigraphy, recording of intrauterine pressure, electrohysterography and Doppler sonography of the Fallopian tubes. After application to the posterior vaginal fornix, a rapid (within minutes) uptake of the labelled particles into the uterus was observed during the follicular and during the luteal phase of the cycle in all patients. Transport into the oviducts, however, could only be demonstrated during the follicular phase. Transport was directed predominantly into the tube ipsilateral to the ovary bearing the dominant follicle; the contralateral oviduct appeared to be functionally closed. The proportion of patients exhibiting ipsilateral transport did increase concomitant with the increase of the diameter of the dominant follicle. That ipsilateral transport has biological significance is suggested by the observation that the pregnancy rate following spontaneous intercourse or insemination was significantly higher in those women in whom ipsilateral transport could be demonstrated than in those who failed to exhibit lateralization. Oxytocin administration was followed by a dramatic increase in the amount of material transported to the ipsilateral tube, as demonstrated by radionuclide imaging and by Doppler sonography following instillation of ultrasound contrast medium. Continuous recording of intrauterine pressure before and after oxytocin administration did show an increase in basal tonus and amplitude of contractions and a reversal of the pressure gradient from a fundo-cervical to a cervico-fundal direction. These actions of oxytocin were accompanied by an increase in amplitude of potentials recorded by electrohysterography. These data support the view that uterus and Fallopian tubes represent a functional unit that is acting as a peristaltic pump and that the increasing activity of this pump during the follicular phase of the menstrual cycle is reflected by an increased transport into the oviduct ipsilateral to the ovary bearing the dominant follicle. In addition, they strongly suggest a critical role of oxytocin in this process. Failure of this mechanism appears to be a cause of subfertility or infertility, as indicated by the low pregnancy rate following intrauterine insemination or normal intercourse in the presence of patent Fallopian tubes. It may be regarded as a new nosological entity for which we propose the term tubal transport disorder (TTD). Since pregnancy rate of such patients is normal when treated with in-vitro fertilization (IVF), hysterosalpingoscintigraphy seems to be useful for the choice of treatment modalities in patients with patent Fallopian tubes suffering from infertility.

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Section: Normal and Disturbed Function Of The Uterus And Fallopian Tubesmentioning

confidence: 99%

Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography

Wildt

Kissler²,

Licht³

et al. 1998

Human Reproduction Update

139

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“…In some mammals this response is manifest by a train of short-lived contractions (e.g. rabbits: Fuchs, 1972; women: Masters & Johnson, 1966;Fox, Wolff & Baker, 1970). The rat also shows this pattern.…”

Section: Effect Ofnon-vaginal Mating Stimulationmentioning

confidence: 99%

Influence of mating and vaginocervical stimulation on rat uterine activity

Toner¹,

Adler²

1986

Reproduction

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“…However, it is also well established that strong peristalsis does not facilitate sperm transport, but often reduces fertility [22,25]. Indeed, the uterus responds to mating by increasing its contractile rate, but only transiently, for less than 1 min in the ewe [12,42] and macaque [14,44], or for no longer than 2 min in the rabbit [11] and woman [10]. Therefore, it is tempting to speculate that a secretion of OT altering the contractile rate of the uterus for a long period is detrimental to fertility in a number of species, including the ewe.…”

Section: Discussionmentioning

confidence: 99%

Plasma levels of cortisol and oxytocin, and uterine activity after cervical artificial insemination in the ewe

et al. 2002

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-The objective was to compare in the ewe the effects of easy and difficult procedures for artificial insemination (AI) (as related to rapid or poor accessibility of the cervix, respectively) on plasma cortisol (CORT) and oxytocin (OT), and uterine motility. All AI were simulated using a catheter empty of semen to study genital and environmental stimuli only. In experiment 1, 40 ewes were sampled after AI, and whether it was an easy or difficult procedure was reported for each animal. While CORT concentrations rose to a similar amount in all ewes, whatever the AI procedure, a significant OT response occurred after a difficult procedure only (n = 18) (17.4 ± 1.7 versus 12.7 ± 0.7 pg . mL -1 before AI, p < 0.05). In experiment 2, uterine activity was monitored in 4 ewes using an implantable telemetric transmitter equipped with an intrauterine pressure catheter. An increased uterine activity occurred during 2 ± 1 min after an easy AI (n = 5), whereas the evoked activity lasted for 15 ± 4 min after a difficult AI (p < 0.001, n = 7). A similar long-lasting response occurred after OT administration (100 mIU, i.v.). We concluded that the increase in uterine motility after a difficult AI resulted from a reflex release of OT, and not to a "stress" effect.artificial insemination / cortisol / oxytocin / uterine contractions / telemetry Reprod. Nutr. Dev. 42 (2002) [381][382][383][384][385][386][387][388][389][390][391][392] 381

show abstract

Measurement of Intra-Vaginal and Intra-Uterine Pressures During Human Coitus by Radio-Telemetry

Cited by 129 publications

References 5 publications

Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography

Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography

Influence of mating and vaginocervical stimulation on rat uterine activity

Plasma levels of cortisol and oxytocin, and uterine activity after cervical artificial insemination in the ewe

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