Measurement of Lycopene Effectiveness on Lung and Kidney Cancer Cells by Quantitative 1h Magnetic Resonance Imaging in Vitro

Abstract

This study aimed to utilize Magnetic Resonance Imaging (MRI) to monitor the effect of Lycopene on cultured cancer cells. Lycopene may be preventive against the development of cancer e.g. lung and kidney. The efficacy of lycopene (2.5 µL/mL, 5.0 µL/mL, and 20 µL/mL) was examined using MRI. T1 relaxation time was measured prior to and after 24 h of treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells. The untreated cell lines (A549 and ACHN) were considered as a control. The study shows that T1 relaxation can be used for the non-invasive monitoring of cancer cellsí death caused by Lycopene treatment. Lycopene may inhibit the growth of A549 and ACHN cell lines. After Lycopene treatment, we determine changes in spin-lattice relaxation in lung cancer cell line A549 and kidney cancer cell line ACHN.