Measurement of Maternofetal Potential Difference in Parathyroid Hormone Related Protein (PTHrP) Knockout Mice

Dilworth, Mark; Glazier, Jocelyn D.; Cowley, E; Boyd, R. D.; Husain, Shahid; Sibley, CP; Ward, Barbara J.

doi:10.1016/j.placenta.2008.09.006

Cited by 1 publication

(1 citation statement)

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“…The magnitude and polarity of the electrical potential difference (PD) across the placental exchange barrier has been a topic of much work and debate over many years. It is known that in several species, including possibly human, there is a PD between maternal plasma or extracellular fluid and fetal plasma or extracellular fluid (reviewed in Atkinson et al 2006), and this has recently been demonstrated again in the mouse (Dilworth et al 2008). However, there is uncertainty as to whether this maternofetal PD is equivalent to a transplacental PD, i.e.…”

Section: Electrochemical Gradientsmentioning

confidence: 99%

Understanding placental nutrient transfer – why bother? New biomarkers of fetal growth

Sibley

2009

The Journal of Physiology

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The placenta, in general and the physiology of maternofetal nutrient transfer is under-researched compared to other organs with epithelial transport function, as evidenced, for example, by publication numbers. This report provides reasons why more researchers should become involved in this topic. First, the syncytiotrophoblast, the transporting epithelium of the placenta, though having many basic cell physiology properties similar to those of other transporting epithelia, has several properties which are markedly different. Better information on these might help fundamental understanding of how epithelia in general function as well as improving knowledge of how the syncytiotrophoblast operates. Second, the synctiotrophoblast has a key role in controlling fetal growth, not only by transporting nutrients and waste products of metabolism but also because it increasingly appears to be one site, perhaps even the dominant site, in which integration of, sometimes conflicting, signals between mother and fetus takes place. Finally, better understanding of placental nutrient transfer and especially of how it is regulated by maternal and fetal signals could provide better information on the placental phenotype in fetal growth disorders -information which might contribute to providing better biomarkers which the obstetrician could use to improve early diagnosis of these disorders.

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Section: Electrochemical Gradientsmentioning

confidence: 99%