Measurement of Mechanical Properties of Soft Tissues In Vitro Under Controlled Tissue Hydration

Shahmirzadi, Danial; Bruck, Hugh A.; Hsieh, Adam H.

doi:10.1007/s11340-012-9644-y

Cited by 17 publications

(13 citation statements)

References 61 publications

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“…Excess hydration is known to negatively influence the behaviour of the cornea through creation of surface epithelial irregularity and alteration of the tear film-air interface (38). Investigations into the biomechanical properties of soft tissues have supported this notion, with behaviour linked with extracellular matrix (ECM) hydration both in vivo and in vitro (39). The viscoelastic properties of articular cartilage for example, have been shown to alter depending on hydration, with reduced ability to dissipate energy and resultant increased likelihood of rupture in a hyperhydrated state (as in osteoarthritis) (40).…”

Section: Hydration Of Tissues and Cellsmentioning

confidence: 99%

“…The viscoelastic properties of articular cartilage for example, have been shown to alter depending on hydration, with reduced ability to dissipate energy and resultant increased likelihood of rupture in a hyperhydrated state (as in osteoarthritis) (40). At the cellular level, the properties of elastin have shown significant stiffening with dehydration, resulting in reduced fatigue resistance to cyclic loading particularly at high frequency (39). …”

Section: Hydration Of Tissues and Cellsmentioning

confidence: 99%

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Systemic Hydration: Relating Science to Clinical Practice in Vocal Health

Hartley

Thibeault

2014

Journal of Voice

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Objectives To examine the current state of the science regarding the role of systemic hydration in vocal function and health. Study Design Literature Review Methods Literature search spanning multiple disciplines, including speech-language pathology, nutrition and dietetics, medicine, sports and exercise science, physiology and biomechanics. Results The relationship between hydration and physical function is an area of common interest amongst multiple professions. Each discipline provides valuable insight into the connection between performance and water balance, as well as complimentary methods of investigation. Existing voice literature suggests a relationship between hydration and voice production, however the underlying mechanisms are not yet defined and a treatment effect for systemic hydration remains to be demonstrated. Literature from other disciplines sheds light on methodological shortcomings and in some cases offers an alternative explanation for observed phenomena. Conclusions A growing body of literature in the field of voice science is documenting a relationship between hydration and vocal function, however greater understanding is required to guide best practice in the maintenance of vocal health and management of voice disorders. Integration of knowledge and technical expertise from multiple disciplines facilitates analysis of existing literature and provides guidance as to future research.

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Section: Hydration Of Tissues and Cellsmentioning

confidence: 99%

Section: Hydration Of Tissues and Cellsmentioning

confidence: 99%

Systemic Hydration: Relating Science to Clinical Practice in Vocal Health

Hartley

Thibeault

2014

Journal of Voice

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“…Shahmirzadi and colleagues [19,20] found that decreased hydration not only made the tissue stiffer but also slowed stress relaxation. Those results were obtained using aortic tissue submerged in liquids and required maintaining the samples at a hydration equilibrium.…”

Section: Resultsmentioning

confidence: 99%

Comparative quasi-static mechanical characterization of fresh and stored porcine trachea specimens

Butler

Williams

Tucker

et al. 2018

Eur. Phys. J. Spec. Top.

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Abstract. Tissues of the upper airways of critically ill patients are particularly vulnerable to mechanical damage associated with the use of ventilators. Ventilation is known to disrupt the structural integrity of respiratory tissues and their function. This damage contributes to the vulnerability of these tissues to infection. We are currently developing tissue models of damage and infection to the upper airways. As part of our studies, we have compared how tissue storage conditions affect mechanical properties of excised respiratory tissues using a quasi-static platform. Data presented here show considerable differences in mechanical responses of stored specimens compared to freshly excised specimens. These data indicate that implementation of storage and maintenance procedures that minimize rapid degradation of tissue structure are essential for retaining the material properties in our tissue trauma models.

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“…Children have a high content of tightly bound water in organism that gradually decreases with advanced age. Dehydration results in increase of tissue stiffness [10][11][12] and can be linked with glycation processes and accumulation of glycation end products [13]. This means that dehydration and glycation processes, as well as bound water release and transformation into loosely bound and free water, play important roles both in age-related pathologies, such as cardiovascular diseases, diabetes, cancer, and obesity due to increased stiffness and, very likely, in COVID-19.…”

Section: Aging Dehydration Glycation and Stiffnessmentioning

confidence: 99%

Tissue Integrity and COVID-19

Kerch

2021

Encyclopedia

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Tissue integrity depends on biological tissue stiffness. Tissue integrity can protect both against age-related diseases and against severity of COVID-19. The disruption of tight junctions and increase of tissue permeability with advancing age can be related with age-related diseases as well as with age-dependent COVID-19. Release of tightly bound water from collagen fibrils leads to the increase of extracellular matrix stiffness and to the associated with matrix stiffness increased tissue permeability. The link between arterial stiffness and oxidative stress has been reported and is expected to be studied in more detail in the future. Trehalose can be suggested for retardation of tightly bound water release and subsequent extracellular matrix crosslinking by advanced glycation end products. Increase in tissue permeability can be blocked by polyphenols that inhibit ICAM-1 expression and mitigate cytoskeleton reorganization. NF-κB activation as a result of increased stiffness and cytoskeleton reorganization can cause both cardiovascular pathologies and COVID-19. Increased cholesterol content in cell membrane leads to increased virus entry into cell and increase of cholesterol is linked with cardiovascular diseases. Statins and chitosan are known as cholesterol-lowering substances. Nrf2 inhibits NF-κB activation and NF-κB inhibits Nrf2 pathway.

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Measurement of Mechanical Properties of Soft Tissues In Vitro Under Controlled Tissue Hydration

Cited by 17 publications

References 61 publications

Systemic Hydration: Relating Science to Clinical Practice in Vocal Health

Systemic Hydration: Relating Science to Clinical Practice in Vocal Health

Comparative quasi-static mechanical characterization of fresh and stored porcine trachea specimens

Tissue Integrity and COVID-19

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