Measurement of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Fe</mml:mi></mml:mrow><mml:mprescripts/><mml:none/><mml:mrow><mml:mn>58</mml:mn></mml:mrow></mml:mmultiscripts><mml:mo stretchy="false">(</mml:mo><mml:mi>p</mml:mi><mml:mo>,</mml:mo><mml:mi>n</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Co</mml:mi></mml:mrow><mml:mprescripts/><mml:none/><mm

The emerging success of [68Ga/177Lu]Ga/Lu-DOTATATE as a theranostic pair has spurred interest in other isotopes as potential theranostic combinations. Here, we review cobalt-55 and cobalt-58m as a potential theranostic pair. Radionuclidically pure cobalt-55 and cobalt-58m have been produced on small cyclotrons with high molar activity. In vitro, DOTATOC labeled with cobalt has shown greater affinity for SSTR2 than DOTATOC labeled with gallium and yttrium. Similarly, [58mCo]Co-DOTATATE has shown improved cell-killing capabilities as compared to DOTATATE labeled with either indium-111 or lutetium-177. Finally, PET imaging with an isotope such as cobalt-55 allows for image acquisition at much later timepoints than gallium, allowing for an increased degree of biological clearance of non-bound radiotracer. We discuss the accelerator targetry and radiochemistry used to produce cobalt-55,58m, emphasizing the implications of these techniques to downstream radiotracers being developed for imaging and therapy.

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“… Cross section data for production of cobalt-58m and cobalt-58g from iron-58 [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. …”

Section: Figurementioning

confidence: 99%

Production, Purification, and Applications of a Potential Theranostic Pair: Cobalt-55 and Cobalt-58m

et al. 2021

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Extension of evaluated cross section database for charged particle monitor reactions

Tárkányi,

Hermanne,

Ignatyuk

et al. 2024

J Radioanal Nucl Chem

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The evaluation and deduction of recommended cross section values allowing extension of the database to monitor energy and intensity parameters of charged particle beams is presented. Included are 53 charged particle (p, d, 3He, 4He) induced reactions on suited C, Al, Ti, Fe, Ni, Cu, Nb and Au targets. The new data allow more systematic simultaneous use of multiple reactions on the same target and promote the backings of electrodeposited and sedimented targets as monitoring aids. Where possible the energy range is extended to above 100 MeV. Integral yield curves over the studied energy range are derived and compared to experimentally measured yields at specific energy points. A comparison with the theoretical excitation curve prediction of the TALYS-code as available in the TENDL 2021–2023 libraries is shown.

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The atomic nucleus, nuclear radiation, and the interaction of radiation with matter

L’Annunziata¹

2020

Handbook of Radioactivity Analysis

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Measurement ofFe58(p,n)Co

Cited by 7 publications

References 21 publications

Production, Purification, and Applications of a Potential Theranostic Pair: Cobalt-55 and Cobalt-58m

Production, Purification, and Applications of a Potential Theranostic Pair: Cobalt-55 and Cobalt-58m

Extension of evaluated cross section database for charged particle monitor reactions

The atomic nucleus, nuclear radiation, and the interaction of radiation with matter

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