Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols

Hermansen, Flemming; Rosen, Stuart D.; Fath‐Ordoubadi, Farzin; Kooner, Jaspal S.; Clark, John C.; Camici, Paolo G.; Lammertsma, Adriaan A.

doi:10.1007/s002590050279

Cited by 82 publications

(76 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter set was projected on the dynamic H 2 15 O images to generate image-derived input functions. The standard single-tissue-compartment model was used together with these input functions to determine myocardial blood flow (mL/ min/mL of perfusable tissue), including intrinsic corrections for spillover from both left and right ventricles (14).…”

Section: Pet Studymentioning

confidence: 99%

Microvascular Function in Viable Myocardium After Chronic Infarction Does Not Influence Fractional Flow Reserve Measurements

Marques¹,

Knaapen

Boellaard

et al. 2007

Journal of Nuclear Medicine

View full text Add to dashboard Cite

Fractional flow reserve (FFR) is an index of coronary stenosis severity. FFR is the ratio of hyperemic myocardial flow in the stenotic area to maximal flow in that same territory without stenosis and can be measured with a pressure wire. In patients with prior infarction, measuring FFR in infarct-related arteries may be different for 2 reasons: a smaller mass of viable myocardium depending on the stenotic infarct-related artery and greater microvascular resistance in the infarcted area than in the reference area. When microvascular resistance does not differ between the infarcted and the reference areas, FFR should equal relative flow reserve (RFR). RFR is the ratio of myocardial blood flow in the stenotic area to blood flow in a normally perfused reference area, at maximal hyperemia. H 2 15 O PET measures myocardial flow within only the viable areas of an infarct and can be used to measure RFR. The present study assessed in patients with chronic myocardial infarction whether microvascular resistance in the infarct is different from that in the reference area. Therefore, the correlation between FFR and RFR using H 2 15 O PET was studied. Methods: In the catheterization laboratory, FFR was measured in the infarct-related artery and a reference coronary artery. The H 2 15 O PET study and FFR measurements were performed on the same day in 22 patients. Results: In 27 patients, the mean interval between the PET study and infarction was 3.3 y. Most patients had an anterior infarction, and the mean ejection fraction was 44%. The mean FFR and RFR values were 0.75 6 0.16 and 0.74 6 0.18, respectively. A significant correlation (r 5 0.81; P , 0.0001) was found between FFR and RFR. The linear regression line was close to the line of identity. Conclusion: In patients with chronic myocardial infarction and a reduced ejection fraction, a good correlation was found between FFR measurements in the infarct-related artery and RFR. Because the linear regression line between FFR and RFR was close to the line of identity, one can conclude that microvascular resistance in the viable myocardium does not differ from that in the reference area.

show abstract

Section: Pet Studymentioning

confidence: 99%

Microvascular Function in Viable Myocardium After Chronic Infarction Does Not Influence Fractional Flow Reserve Measurements

Marques¹,

Knaapen

Boellaard

et al. 2007

Journal of Nuclear Medicine

View full text Add to dashboard Cite

show abstract

“…O data were fitted to a standard four-parameter, singletissue compartment model including MBF, perfusable tissue fraction and spill-over fractions from both ventricles [18]. The left ventricular cavity TAC was used as input function to the model.…”

mentioning

confidence: 99%

Kinetic models for analysing myocardial [11C]palmitate data

Jong

Rijzewijk

Lubberink

et al. 2009

Eur J Nucl Med Mol Imaging

Self Cite

View full text Add to dashboard Cite

Purpose [ 11 C]Palmitate PET can be used to study myocardial fatty acid metabolism in vivo. Several models have been applied to describe and quantify its kinetics, but to date no systematic analysis has been performed to define the most suitable model. Methods In this study a total of 21 plasma input models comprising one to three compartments and up to six free rate constants were compared using statistical analysis of clinical data and simulations. To this end, 14 healthy volunteers were scanned using [ 11 C]palmitate, whilst myocardial blood flow was measured using H 2 15 O. Results Models including an oxidative pathway, representing production of 11 CO 2 , provided significantly better fits to the data than other models. Model robustness was increased by fixing efflux of 11 CO 2 to the oxidation rate. Simulations showed that a three-tissue compartment model describing oxidation and esterification was feasible when no more than three free rate constants were included. Conclusion Although further studies in patients are required to substantiate this choice, based on the accuracy of data description, the number of free parameters and generality, the three-tissue model with three free rate constants was the model of choice for describing [ 11 C] palmitate kinetics in terms of oxidation and fatty acid accumulation in the cell.

show abstract

“…Then, 15 O-labeled carbon monoxide was administered by inhalation, and a single-frame scan was performed to image the blood pool (5,6). After allowing 10 min for decay of 15 O radioactivity, 15 O-water (10.5 MBq/kg) was injected intravenously over 20 s at an infusion rate of 10 ml/min to measure myocardial blood flow (MBF), as previously described (16,17). A primedcontinuous (40 mU ⅐ min Ϫ1 ⅐ m Ϫ2 ) systemic infusion of insulin was started immediately after the 15 O-water scan, and a 150-min euglycemic-hyperinsulinemic clamp was carried out (18).…”

Section: Subjectsmentioning

confidence: 99%

Independent Association of Type 2 Diabetes and Coronary Artery Disease With Myocardial Insulin Resistance

et al. 2002

Self Cite

View full text Add to dashboard Cite

Clustering of classical cardiovascular risk factors is insufficient to account for the excess coronary artery disease (CAD) of patients with diabetes, and chronic hyperglycemia and insulin resistance (IR) are obvious culprits. Whole-body and skeletal muscle IR is characteristic of patients with type 2 diabetes, but whether it extends to the normally contracting cardiac muscle is controversial. We investigated whether type 2 diabetes is associated with myocardial IR independent of CAD in a case-control series (n ‫؍‬ 55) of male nondiabetic and diabetic (type 2 and type 1) patients with or without angiographically documented CAD. Baseline blood flow ( 15 O-water) and insulin-stimulated glucose uptake ( 18 Ffluoro-deoxyglucose) during euglycemic (5.6 mmol/l), physiological hyperinsulinemia (40 mU ⅐ min ؊1 ⅐ m ؊2 insulin clamp) were measured by positron emission tomography in skeletal muscle and normally contracting myocardium. Skeletal muscle glucose uptake was reduced in association with both CAD and type 2 diabetes. In regions with normal baseline perfusion, insulinmediated myocardial glucose uptake was reduced in non-CAD type 2 diabetic (0.36 ؎ 0.14 mol ⅐ min ؊1 ⅐ g ؊1 ) and nondiabetic CAD patients (0.44 ؎ 0.15 mol ⅐ min ؊1 ⅐ g ؊1 ) in comparison with healthy control subjects (0.61 ؎ 0.08) or with non-CAD type 1 diabetic patients (0.80 ؎ 0.13; P < 0.001 for both CAD and diabetes). Neither basal skeletal muscle nor basal myocardial blood flow differed across groups; both skeletal muscle and myocardial IR were directly related to whole-body IR. We conclude that type 2 diabetes is specifically associated with myocardial IR that is independent of and nonadditive with angiographic CAD and proportional to skeletal muscle and whole-body IR. Diabetes 51:3020 -3024, 2002

show abstract

Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols

Cited by 82 publications

References 19 publications

Microvascular Function in Viable Myocardium After Chronic Infarction Does Not Influence Fractional Flow Reserve Measurements

Microvascular Function in Viable Myocardium After Chronic Infarction Does Not Influence Fractional Flow Reserve Measurements

Kinetic models for analysing myocardial [11C]palmitate data

Independent Association of Type 2 Diabetes and Coronary Artery Disease With Myocardial Insulin Resistance

Contact Info

Product

Resources

About