Measurement of normal left heart dimensions using optimally oriented MR images

Kaul, Sanjiv; Wismer, GL; Brady, T J; Johnston, DL; Weyman, Arthur E.; Okada, R; Dinsmore, Robert E.

doi:10.2214/ajr.146.1.75

Cited by 69 publications

(18 citation statements)

References 18 publications

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“…The wall thickness has decreased by about 17% for the dual-MF technique as compared with the standard ungated method currently used for perfusion imaging. These results are closer to average thickness as reported by MR imaging techniques (10.3 6 1.2 mm at end-diastole) (21). The myocardium-to-blood contrast increased more than 59% and CNR increased more than 89% for the dual-MF technique as compared with the reference ungated technique.…”

Section: Tablesupporting

confidence: 82%

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

et al. 2015

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A novel PET radiotracer, Flurpiridaz F 18, has undergone phase II clinical trial evaluation as a high-resolution PET cardiac perfusion imaging agent. In a subgroup of patients imaged with this agent, we assessed the feasibility and benefit of simultaneous correction of respiratory and cardiac motion. Methods: In 16 patients, PET imaging was performed on a 4-ring scanner in dual cardiac and respiratory gating mode. Four sets of data were reconstructed with high-definition reconstruction (HD•PET): ungated and 8-bin electrocardiographygated images using 5-min acquisition, optimal respiratory gating (ORG)-as developed for oncologic imaging-using a narrow range of breathing amplitude around end-expiration level with 35% of the counts in a 7-min acquisition, and 4-bin respiration-gated and 8-bin electrocardiography-gated images (32 bins in total) using the 7-min acquisition (dual-gating, using all data). Motion-frozen (MF) registration algorithms were applied to electrocardiography-gated and dual-gated data, creating cardiac-MF and dual-MF images. We computed wall thickness, wall/cavity contrast, and contrast-to-noise ratio for standard, ORG, cardiac-MF, and dual-MF images to assess image quality. Results: The wall/cavity contrast was similar for ungated (9.3 ± 2.9) and ORG (9.5 ± 3.2) images and improved for cardiac-MF (10.8 ± 3.6) and dual-MF images (14.8 ± 8.0) (P , 0.05). The contrast-to-noise ratio was 22.2 ± 9.1 with ungated, 24.7 ± 12.2 with ORG, 35.5 ± 12.8 with cardiac-MF, and 42.1 ± 13.2 with dual-MF images (all P , 0.05). The wall thickness was significantly decreased (P , 0.05) with dual-MF (11.6 ± 1.9 mm) compared with ungated (13.9 ± 2.8 mm), ORG (13.1 ± 2.9 mm), and cardiac-MF images (12.1 ± 2.7 mm). Conclusion: Dual (respiratory/cardiac)-gated perfusion imaging with Flurpiridaz F 18 is feasible and improves image resolution, contrast, and contrastto-noise ratio when MF registration methods are applied. (2) and better image quality, interpretative certainty, and diagnostic performance than SPECT in a phase 2 clinical trial (3). In particular, imaging with this 18 F-based radiotracer generated higher-resolution cardiac images (4).However, the high image resolution associated with an 18 F-based tracer can be degraded by cardiac and respiratory motion during PET acquisition, leading to image blurring. If such motion is not corrected, the full-potential imaging resolution of Flurpiridaz F 18 may not be realized. We have previously developed a motion-frozen (MF) technique for myocardial perfusion imaging, which recovers resolution lost due to cardiac motion, improving contrast and quantitative diagnostic accuracy (5,6). This technique was also successfully used for automatic coregistration of SPECT with CT angiography (CTA) (7,8) and for contrast improvement in cardiac PET (9).The aim of this study was to investigate the feasibility of myocardial perfusion imaging by Flurpiridaz F 18 PET with correction of both cardiac and respiratory motion. We hypothesized that the myocardial perfusion image quality for F...

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Section: Tablesupporting

confidence: 82%

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

et al. 2015

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“…However, it has been shown that the LV strated in studies that show the accuracy of this technique for measuring cardiac dimensions. [3][4][5][6][7] Preliminary studies have demonstrated the potential of NMR imaging for assessing LV volumes. [8][9][10][11][12][13][14] These studies have used either imaging planes aligned with the axes of the body9J12"3 rather than the intrinsic axes of the heart, or spin-echo pulse sequences that require long acquisition times.…”

Section: Assessment Of Left Ventricular (Lv) Functionmentioning

confidence: 99%

Left ventricular volume measurement using cardiac axis nuclear magnetic resonance imaging. Validation by calibrated ventricular angiography.

et al. 1990

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Proton nuclear magnetic resonance (NMR) imaging has the potential to serially assess left ventricular (LV) volumes with optimal accuracy because it is a high-resolution, threedimensional, noninvasive modality. Previous NMR studies to assess LV volumes have been suboptimal, as they have used either planes aligned with the axes of the body, which are compromised by partial volume effects, or spin-echo techniques that have been time-consuming to acquire and analyze. Accordingly, for LV volume measurement, we developed a gradient-echo (cine) NMR strategy that uses two orthogonal planes intersecting along the intrinsic long axis of the heart (two-chamber and four-chamber). This approach was validated against calibrated contrast biplane LV cineangiography (CATH) and also compared with a previously reported short-axis spin-echo NMR method. Twenty-one patients underwent CATH and NMR (longaxis, n=21; short-axis, n=14) within a 3-day interval. Although both long-and short-axis NMR LV volumes and ejection fractions correlated well with CATH (r>0.90, p

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“…In 1984, Longmore et al [16] reported that the measurement by angiocardiography was higher than that in MRI. In 1986, Kaul et al [17] reported that two-dimensional echocardiography had a strong correla- Note: The interaction effect was determined using a paried t test model. tion with MRI.…”

Section: Discussionmentioning

confidence: 99%

A Study on Comparison of Cardiac Ejection Fraction Values Measured in Myocardium SPECT and Cine MRI

Han¹,

Dong²,

Park³

et al. 2012

Journal of Magnetics

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This study examined the correlation between MR cine and myocardium Single-photon emission computed tomography (SPECT) by comparing the measured cardiac ejection fractions. The usefulness of cardiac MRI was also evaluated. Ten patients (8 men, 2 women and average age of 58.6 years), who underwent a myocardium SPECT scan and cardiac cine MRI scan among patients who visited the hospital for the chief complaint of cardiac disorder from June 1, 2010 to February 10, 2011, were enrolled in this study. The cardiac ejection fraction was calculated from the images obtained in both scans. The data was used to examine the correlation. The regression equation the cardiac ejection fraction values of the 10 patients obtained in myocardium SPECT and MRI cine was Y = 1.12X−8.91 (R 2 = 0.78, significance of F = 0.001639, and confidence level of 95%). The results were significant when the cardiac ejection fraction obtained from MRI cine was compared with that obtained from myocardium SPECT. Overall, a cardiac examination using MRI enables an investigation of not only the ejection fraction but also the ED and ES volumes, stroke volume, wall thickness, and wall thickening in a higher spatial resolution despite the examination being conducted once. This examination is believed to be very useful for diagnosing patients with cardiac disease.

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Measurement of normal left heart dimensions using optimally oriented MR images

Cited by 69 publications

References 18 publications

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

Left ventricular volume measurement using cardiac axis nuclear magnetic resonance imaging. Validation by calibrated ventricular angiography.

A Study on Comparison of Cardiac Ejection Fraction Values Measured in Myocardium SPECT and Cine MRI

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