Measurement of Ocular Tumor Volumes From Serial, Cross-Sectional Ultrasound Scans

Rh, Silverman; Dj, Coleman; Rondeau, Mark J.; Sm, Woods; Fl, Lizzi

doi:10.1097/00006982-199313010-00015

Cited by 19 publications

(10 citation statements)

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“…While early scans for evaluation of intraocular masses were focused on identifying presence and location, later research focused on better quantifying such tumors [38,39]. By taking serial cross-sectional scans over the shape of the tumor, the shape and volume of the tumor could be estimated [40,41]. This helped to improve evaluation and characterization of intraocular masses and guided radioactive plaque placement.…”

Section: Ultrasound Use In Ophthalmologymentioning

confidence: 99%

“…Another limitation is that traditional B-mode scanning can only evaluate structures directly opposite to the probe and cannot provide information in the XY plane without 3D reconstruction. While 3D reconstruction was shown to be possible [40,41] and could give information about the XY planes, such imaging required time consuming serial acquisition of small 2D image slices and subsequent reconstruction. This meant that while 3D reconstruction is possible, it is too cumbersome to be used frequently in the average clinical setting.…”

Section: Ultrasound Use In Ophthalmologymentioning

confidence: 99%

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A Brief Overview of Ophthalmic Ultrasound Imaging

Rosen¹,

Conway²,

Ingram³

et al. 2019

Novel Diagnostic Methods in Ophthalmology

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Ultrasound is one of the oldest imaging modalities. Sound waves are emitted into the body, and the returning echoes can be interpreted. It has become widely used because it can easily be done at bedside with a relatively small apparatus and does not expose the patient to any ionizing radiation. While this technique has seen widespread acceptance in other fields such as cardiology or obstetrics and gynecology, the general use in ophthalmology has been somewhat limited. However, recent advancements in ultrasonic arrays can be a powerful tool in the evaluation of ophthalmic pathology. Such systems can quickly generate very high detail images and 3D reconstructions without the need for extensive manual scanning. The application of this technology includes evaluation of traumatic eye injuries; assessing presence and location of an intraocular foreign body; evaluation of intraocular tumors, including small tumors that have not yet caused visual distortion; evaluation of retinal detachment; and evaluation of vascular disease. The goal of this article is to briefly review the history and development of ultrasound and to provide an overview of the most current systems and applications of ultrasound use in ophthalmologic clinical evaluation.

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Section: Ultrasound Use In Ophthalmologymentioning

confidence: 99%

Section: Ultrasound Use In Ophthalmologymentioning

confidence: 99%

A Brief Overview of Ophthalmic Ultrasound Imaging

Rosen¹,

Conway²,

Ingram³

et al. 2019

Novel Diagnostic Methods in Ophthalmology

View full text Add to dashboard Cite

show abstract

“…The accurate diagnosis of intraocular tumors is thereby critical in the management and follow-up of the patients. The diagnosis of intraocular tumors is usually based on clinical examination with imaging techniques such as fluorescein or indocyanine angiographies [5,6], optical coherence tomography [7], and acoustic backscattering based ultrasound (US) imaging [8,9]. Tumors with atypical clinical or imaging features may need fine-needle aspiration biopsy for diagnosis [10].…”

Section: Introductionmentioning

confidence: 99%

Characterizing intraocular tumors with photoacoustic imaging

Xue

Gursel

et al. 2016

SPIE Proceedings

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Intraocular tumors are life-threatening conditions. Long-term mortality from uveal melanoma, which accounts for 80% of primary intraocular tumors, could be as high as 25% depending on the size, ciliary body involvement and extraocular extension. The treatments of intraocular tumors include eye-sparing approaches such as radiotherapy and thermotherapy, and the more aggressive enucleation. The accurate diagnosis of intraocular tumors is thereby critical in the management and follow-up of the patients. The diagnosis of intraocular tumors is usually based on clinical examination with acoustic backscattering based ultrasonography. By analyzing the high frequency fluctuations within the ultrasound (US) signals, microarchitecture information inside the tumor can be characterized. However, US cannot interrogate the histochemical components formulating the microarchitecture. One representative example is the inability of US imaging (and other contemporary imaging modalities as well) in differentiating nevoid and melanoma cells as the two types of cells possesses similar acoustic backscattering properties. Combining optical and US imaging, photoacoustic (PA) measurements encode both the microarchitecture and histochemical component information in biological tissue. This study attempts to characterize ocular tumors by analyzing the high frequency signal components in the multispectral PA images. Ex vivo human eye globes with melanoma and retinoblastoma tumors were scanned using less than 6 mJ per square centimeters laser energy with tunable range of 600-1700 nm. A PA-US parallel imaging system with US probes CL15-7 and L22-14 were used to acquire the high frequency PA signals in real time. Preliminary results show that the proposed method can identify uveal melanoma against retinoblastoma tumors.

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“…33 However, in a number of patients the response to treatment may still be classified differently based on volumetric as opposed to one-or two-dimensional imaging. 34 Because the shape of uveal melanomas 30,[35][36][37][38][39][40] varies more widely than that of a typical solid tumor in other organs, tumor thickness is not necessarily the best surrogate measure for tumor volume, and especially for a change in tumor volume. For example, the base of a mushroom-shaped melanoma seems to regress to a different extent than the part that has broken through Bruch's membrane.…”

mentioning

confidence: 99%

“…For example, the base of a mushroom-shaped melanoma seems to regress to a different extent than the part that has broken through Bruch's membrane. Although volume measurements of uveal melanoma have been obtained from time to time, 38,[41][42][43][44] none of these methods has become routine. Formulas for estimating tumor volume from two-dimensional measurements of uveal melanoma have proved inconsistent and largely unsatisfactory.…”

mentioning

confidence: 99%