Measurement of oxidative stress parameters, vitamin D and vitamin D binding protein during vitamin D treatment in a patient with amyotrophic lateral sclerosis

Abstract

Background: Question arises if Amyotrophic lateral sclerosis (ALS, Lou-Gehrig-Syndrom, Charcot-disease) is considered to be an autoimmune disorder that affects the nerval filaments of α-motoneurons in the central nervous system (CNS) due to oxidative stress. SOD mutations seem to play a genetic disorder role in glycosylation and oxidative modifications of neuronal filaments. Vitamin D (VitD) and Vitamin D binding protein (VDBP) has potency to act as an immune modulator. The present study was undertaken to examine the effects of a 34-week vitD supplementation of ImmunoD  , a stabilized Vitamin D3 complex, in a patient with ALS on oxidative stress parameters, nitrosative stress parameter, VitD status and VDBP.