Measurement of paraoxonase and telomerase enzymes and HDL (high density lipoprotein) values and research of their possible relationships with each other in bloodserum of obese cats

Abstract

Today, obesity is seen as a serious health problem in domestic cats. Paraoxonase1 (PON1) is a negative acute phase protein with anti-inflammatory properties. PON1 is transported by linking to different parts of HDL in the blood and has a protective feature of HDL against oxidation. Telomerase is reverse transcriptase enzyme that synthesizes and protects telomeres. Telomere length becomes shorter due to stress, obesity, and lack of exercise. In this study, paraoxonase1, telomerase enzymes and HDL values in blood serum of obese and non-obese cats were measured and their relationships with each other were evaluated. Body fat ratio in cats with body fat measurement system, those above 30% were evaluated as obese, and those below 30% were evaluated as the control group. Paraoxonase1 (p<0.001), telomerase (p<0.001) and HDL (p<0.008) values showed a statistically significant difference between the both groups, it was found to be lower in the obese group compared to the control group. As a result; paraoxonase1 and telomerase enzymes which are parameters of oxidative stress and are known to decrease in inflammation, were also found to be decreased in obese cats. The fact that HDL values are lower than the control group is an indicator that there are diseases that occur together with obesity.