Measurement of Protein Digestion and Absorption in Aged Persons by a Test Meal of I131-labeled Protein

Chinn, Austin B.; Lavik, Paul S.; Cameron, Donald B.

doi:10.1093/geronj/11.2.151

Cited by 20 publications

(5 citation statements)

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“…Ac cording to some authors [ 13] there is an agerelated impairment in the general digestive capacity of individuals without a manifesta tion of gastrointestinal disorders. Others [14] are of the opinion that the capacity to digest and/or absorb large amounts of dietary pro tein is reduced in the elderly as a function of age; according to some investigations [15] protein digestion and absorption are similar in young and old individuals.…”

Section: Discussionmentioning

confidence: 99%

Age-Induced Nerve Cell Loss in the Myenteric Plexus of the Small Intestine in Man

et al. 1993

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We examined the number of nerve cells of the myenteric plexus and the thickness of the smooth muscle in the small intestine in autopsy material of 6 young and 6 old persons. Neurons in the myenteric plexus have been visualised by a nonhistochemical method (Giemsa) in laminar preparations of the muscularis externa. Significant reductions of at least 34% in the number of neurons in the ganglia of the myenteric plexus of the old subjects were recorded in all regions of the small intestine, especially in the duodenum where the number of neurons decreased by over 38%. However, there was no significant correlation between nerve cell count and thickness of intestinal smooth muscle since no difference was found in thickness of intestinal smooth muscle between young and old subjects. The decrease in the neuron density with age could affect the potential of the enteric nervous system to influence control over several small intestinal functional parameters.

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Section: Discussionmentioning

confidence: 99%

Age-Induced Nerve Cell Loss in the Myenteric Plexus of the Small Intestine in Man

et al. 1993

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“…Alternative possibilities have not been supported by previous studies reported by others in the literature. There are no differences between aged individuals and younger persons in terms of: dietary pro-tein requirements (Horwitt, 1953;Keys, 1952b); extent of protein digestion and absorption (Chinn, Lavik, and Cameron, 1956); or blood volume (SklarofT, 1956;Smith, 1958). Furthermore, in our subjects there is no clinical or laboratory evidence for chronic wasting disease, liver disease, hypermetabolic states, or protein loss via urine, edema fluid, or gastrointestinal tract.…”

Section: Serum Proteinsmentioning

confidence: 99%

Medical Investigation of the Processes of Aging.

Libow¹

1963

Human Aging: A Biological and Behavioral Study.

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“…There is a decrease in total body protein with age (Munro, 1983), with the skeletal muscle being primarily affected. Whether dietary protein requirements alter with age is not established, although Chinn et al (1956) using labelled albumin were unable to show any significant difference in protein digestion and absorption between young and old. Protein requirements may be assessed by the factorial method which measures obligatory nitrogen loss while subjects are sustained on a protein-free diet, or the minimum amount of protein needed in the diet to produce N balance may be determined.…”

mentioning

confidence: 98%

Nitrogen balance studies in apparently healthy elderly people and those who are housebound

Bunker¹,

Lawson

Stansfield

et al. 1987

Br J Nutr

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1. Metabolic balance studies (5 d) for nitrogen were carried out in twenty-four apparently healthy elderly people (age 69.7-85.6 years) and a heterogeneous group of twenty housebound elderly people (age 69.9-85.1 years) with chronic diseases. During the study all subjects ate self-selected diets, lived in their own homes and continued their normal daily activities. Seven of the housebound received meals-on-wheels 5 d/week.2. Healthy men and women had mean metabolizable energy intakes of 8.7 and 6.6 MJ/d respectively compared with 6.3 and 4.8 MJ/d in the housebound. The average energy content of the meals-on-wheels as delivered was 2.4 MJ per meal, of which 2.1 MJ were consumed.3. The healthy men and women had average daily protein intakes of 69.4 and 59.7 g respectively compared with 46.3 and 39.1 g in the housebound. Meals-on-wheels as supplied provided 19.4 g protein per meal, of which 16.2 g were consumed.4. Healthy subjects were in equilibrium for N balance (0 mmol/d) with a daily intake of 733 mmol, which was equivalent to 11.04 mmol N (0.97 g mixed protein)/kg body-weight per d. Housebound individuals were in negative N balance (-95 mmol/d) with an intake of 475 mmol/d, corresponding to 7.59 mmol N (0.67 g mixed protein)/kg body-weight per d.5. We were unable to determine in the present study whether the negative N balance observed in the housebound people was due to the relatively low N intake or the underlying disease condition.

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Measurement of Protein Digestion and Absorption in Aged Persons by a Test Meal of I131-labeled Protein

Cited by 20 publications

References 0 publications

Age-Induced Nerve Cell Loss in the Myenteric Plexus of the Small Intestine in Man

Age-Induced Nerve Cell Loss in the Myenteric Plexus of the Small Intestine in Man

Medical Investigation of the Processes of Aging.

Nitrogen balance studies in apparently healthy elderly people and those who are housebound

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