Measurement of protein flux with positron emission tomography in neonates

Nama, Vijay; Kozlowski, Jim; Hamvas, Aaron

doi:10.1136/fn.80.1.f26

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Because functional activity and brain maturation can be indirectly measured by the cerebral metabolic rate, numerous attempts have been made to measure CBF in neonates. In the past, PET [25][26][27][28] and xenon-enhanced CT 29 were used to estimate CBF in neonates. With these methods, a relatively low wbCBF was identified in neonates compared with adults.…”

Section: Discussionmentioning

confidence: 99%

Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation

Kim¹,

Lee²,

Choi³

et al. 2018

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation

Kim¹,

Lee²,

Choi³

et al. 2018

AJNR Am J Neuroradiol

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“…20 For this to occur, any increase in plasma iron levels needs to be reflected in the ELF of the lung. Pulmonary vascular permeability is enhanced in premature babies, 21 particularly in those who go on to develop chronic lung disease. 22 As a consequence of this, any increase in plasma free iron could lead to an increase in the free iron concentration of alveolar ELF.…”

Section: Discussionmentioning

confidence: 99%

Blood transfusion and pulmonary lipid peroxidation in ventilated premature babies

Collard

Godeck

Holley

2005

Pediatric Pulmonology

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Urinary malondialdehyde (MDA; a biochemical marker of lipid peroxidation) is increased following the receipt of blood transfusions in premature babies. This indicates an increased level of oxidative damage somewhere in the body. The aim of this study was to determine whether the lung may be a site of increased oxidative damage following blood transfusions. This was achieved by examining the relationship between blood transfusion and levels of MDA in bronchoalveolar lavage (BAL) fluid from ventilated premature babies. The study was a retrospective analysis of data obtained from a group of 42 ventilated premature babies of less than 32 weeks' gestation. Twenty-seven babies received blood transfusions, and 9 received at least one transfusion during the first week of life when daily BAL samples were being taken. Pulmonary epithelial lining fluid (ELF) was sampled by BAL daily during the first week of life and weekly thereafter. MDA was measured by an established high performance liquid chromatography (HPLC) technique. There was a significant positive correlation between volume of blood transfusions received and peak and mean ELF MDA levels (r=0.810, peak; r=0.740, mean; n=21). During the first week of life, when daily samples were being taken, the mean ELF MDA level after blood transfusion (1.829 microM; SE, 0.529) was significantly greater than before transfusion (0.928 microM; SE, 0.297) (n=9). In babies who received 2 transfusions within the first week (n=5), the MDA level was elevated further following the second transfusion (2.825 microM; SE, 0.346). The results of this study indicate that pulmonary oxidative damage increases after the receipt of blood transfusions. Babies receiving blood transfusions show a greater incidence of pulmonary oxidative stress and poor clinical outcome. This may simply reflect that the sickest babies are those most in need of blood transfusion, and that there is no causal relationship. However, the possibility of a causal relationship between blood transfusions and oxidative damage exists and should be investigated.

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“…However, increased capillary permeability leads to extravasation of albumin and expands the distribution space of the dye, and thus results in overestimation of plasma and blood volume by ICG. Pulmonary capillary leakage is known to occur in preterm infants with RDS [11]. Therefore we studied a relatively homogeneous group in a stable cardiorespiratory condition.…”

Section: Discussionmentioning

confidence: 99%

Blood Volume Assessment with Hemoglobin Subtype Analysis in Preterm Infants

Leipälä¹,

Talme²,

Viitala³

et al. 2003

Neonatology

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The aim of the study was to assess plasma volume (PV) and red cell volume (RCV) in preterm infants with a liquid chromatographic hemoglobin subtype method (HbST) based on dilution of autologous fetal hemoglobin (HbF) by donor adult hemoglobin and measurement of the amount of HbF. PV determination with the indocyanine green dye dilution technique (ICG) was used as a reference method. Eight infants, median gestational age 29.8 weeks (range 27.6–30.9 weeks) and median birth weight 1,300 g (range 1,030–1,760 g), were studied at a median age of 3.0 days (range 1–6 days). RCV was 33.6 ± 12 ml/kg measured with ICG and 32.1 ± 5.2 ml/kg with HbST. PV was 47.0 ± 18 and 40.2 ± 6.6 ml/kg, respectively. There was a close correlation between the RCVs measured with the two techniques (Pearson correlation 0.83, p < 0.05). In conclusion, HbST provides a reliable and safe determination of RCV in preterm infants.

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Measurement of protein flux with positron emission tomography in neonates

Cited by 6 publications

References 15 publications

Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation

Multidelay Arterial Spin-Labeling MRI in Neonates and Infants: Cerebral Perfusion Changes during Brain Maturation

Blood transfusion and pulmonary lipid peroxidation in ventilated premature babies

Blood Volume Assessment with Hemoglobin Subtype Analysis in Preterm Infants

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