Recognizing the key role of innovation in ensuring the definition of managerial and organizational model able to support companies in facing the multiple challenges of sustainable development, the paper focuses on the domain of Responsible innovation (RI) with the aim to depict the role of cross-cultural legitimacy for RI in Asian-Pacific business models. Adopting the interpretative lens provided by Dialectical Systems View, the Yin-Yang dichotomy is discussed for depicting the relationships among focal firms and stakeholders within in Asian-Pacific cross-cultural models. Hypotheses are tested via constructed stepwise regression models using secondary data related to a sample of large Chinese MNEs listed in the Shanghai and Shenzhen stock exchanges over the period from 2009 to 2018. The research shows the multiple influences that cultural legitimacy has in influencing RI and firm performance in the Asian-Pacific cross-cultural business models. Thanks to the study, the current debate about the role of innovation in supporting the definition of sustainable-based business models is enriched through the definition of cross-cultural legitimacy as key driver for RI in Asian-Pacific business models. Thanks to the reflections herein, RI is definitely approached as a holistic domain whose understanding requires to researchers and practioners to overcome traditional business "boundaries." K E Y W O R D S Asian-Pacific business models, cross-cultural legitimacy, dialectical systems view, responsible innovation, Yin-Yang dichotomy 1 | INTRODUCTION Despite the prolonged wounds to the Asian-Pacific economy caused by an unprecedent global public health emergency (GPHE) (i.e., the COVID-19) (World Economy Outlook, 2021), in late 2020 China has played a proactive role in developing the Regional Comprehensive Economic Partnership (RCEP) consisted of main Asian-Pacific countries. This strategic action enhances and deepens socio-economic interdependence and co-creative innovation among organizations bypromoting the emergence and prosperity of cross-cultural business models (CBMs) through which it becomes possible to consider the involved ecological and societal responsibilities when performing scientific innovation activities (Caputo et al., 2019;Chin, Shi, et al., 2021;Singh et al., 2020). Responsible innovation (RI) in CBMs is based on responsible collaboration among firms and their stakeholders for promoting sustainability in innovation practices. Accordingly, the research tries to link RI to the previously under-researched CBM context in the Asian-Pacific.As highlighted by consolidated literature, multinational enterprises (MNEs) often encounter big challenges regarding the building