Measurement of renal function in patients with chronic kidney disease

Sandilands, Euan A; Dhaun, Neeraj; Dear, James W.; Webb, David J.

doi:10.1111/bcp.12198

Cited by 70 publications

(61 citation statements)

References 126 publications

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“…In this study, we used the 5/6 nephrectomy method to generate an experimental model of CKD, which was characterized by high levels of proteinuria and BUN and SCr (three important parameters of renal function) [30,31] in association with increased oxidative stress and inflammation [6]. Moreover, the concentration of plasma TGs and TCs are commonly elevated in experimental animal models of chronic renal failure [32].…”

Section: Discussionmentioning

confidence: 99%

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

et al. 2018

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Salvianolic acid A (SAA) is a minor phenolic carboxylic acid extracted from Salviae miltiorrhizae Bunge (Danshen). SAA exhibits a variety of pharmacological activities, such as antioxidative, anti-thrombotic, neuroprotective, and anti-fibrotic effects, as well as protection from myocardial ischemia and prevention of diabetes and other diseases. Furthermore, SAA has shown renal-protective effects in doxorubicin-induced nephropathy. However, there has been limited research regarding the effects of SAA and underlying mechanisms in chronic kidney disease (CKD). Here, we examined the effects and molecular mechanisms of SAA in an established animal model of 5/6 nephrectomized (5/6Nx) rats. The rats were injected with SAA (2.5, 5, and 10 mg/kg per day, intraperitoneally (ip)) for 28 days. SAA dose-dependently lowered the levels of urine protein, blood urea nitrogen, serum creatinine, plasma total cholesterol, and plasma triglycerides in 5/6Nx rats. Histological examination revealed that SAA dose-dependently attenuated renal pathological lesions, evidenced by reduced renal tubulointerstitial fibrosis by decreasing the expression levels of tumor growth factor-β1 and α-smooth muscle actin in 5/6Nx rats. Moreover, SAA dose-dependently inhibited the activation of nuclear factor-κB (NF-κB) and p38 mitogen-activated protein kinase (MAPK) signaling pathways, subsequently attenuating the secretion of tumor necrosis factor-α and interleukin-1β and inhibiting the expression of monocyte chemotactic protein-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in kidneys of 5/6Nx rats. The above results were consistent with those obtained in lipopolysaccharide-induced HK-2 cells in vitro (a recognized in vitro inflammatory model). In conclusion, our results demonstrated that SAA effectively attenuates kidney injury in 5/6Nx rats. The therapeutic effects of SAA on kidney injury can be attributed to its anti-inflammatory activities through inhibition of the activation of the NF-κB and p38 MAPK signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

et al. 2018

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“…GFR is widely accepted as the best marker of renal function (13). Although urinary inulin clearance is considered the gold standard measurement for GFR, the use of inulin is expensive, invasive, complex and has limited use in routine clinical settings (14,15,16). The creatinine-based eGFR equations are alternative non-invasive methods for easily assessing renal function because of their simplicity (16,17,18).…”

Section: Discussionmentioning

confidence: 99%

The Course of Renal Function After Radical Cystectomy with Ileal Conduit Diversion for Bladder Cancer

Özer¹,

Gören²,

Eğilmez³

et al. 2019

jus

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Amaç: Bu çalışmada mesane kanseri nedeniyle radikal sistektomi ve ileal kondüit diversiyon uygulanan hastalarda böbrek fonksiyonlarındaki değişiklik ve böbrek fonksiyon kaybı için potansiyel risk faktörleri değerlendirildi. Gereç ve Yöntem: Retrospektif çalışmada radikal sistektomi ve ileal kondüit diversiyon yapılan 114 erkek ve 7 kadın, 121 hasta değerlendirildi. Tahmini glomerüler filtrasyon hızı (eGFR) hesaplandı ve postoperatif böbrek fonksiyon değişiklikleri gözden geçirildi. Böbrek fonksiyonlarını etkileyen klinik değişkenler değerlendirildi. Bulgular: Medyan izlem süresi 35,6 ay (dağılım 12,2-139,6 ay) idi. Ortalama eGFR, ameliyat öncesi 78,37±27,58 mL/dakika/1,73 m 2 ve ameliyat sonrası 5. yılda 90,14±29,68 mL/dakika/1,73 m 2 idi. Ameliyat öncesi eGFR ile son takipteki eGFR k arşılaştırması istatistiksel olarak anlamlı bir fark göstermedi (p=1,95). İstatistiksel analiz postoperatif üriner sistem tıkanıklığı gelişiminin ve postoperatif üriner sistem enfeksiyonunun anlamlı olumsuz faktörler olduğunu gösterdi (sırası ile p=0,008, p=0,026). Sonuç: İzlem süreci boyunca, 32 hastanın (%53,3) böbrek fonksiyonlarında azalma görüldü. Postoperatif üriner sistem tıkanıklığının böbrek fonksiyonlarını etkileyen önemli bir olumsuz faktör olduğu bulundu.

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“…ACR measurement is a precise and accurate test for kidney disease, also less likely to experience errors caused by the inaccuracy of urine collection method and variation in 24-hour urinary protein excretion. [7][8][9] Siangproh and co-worker 10 reported the determination of albumin-creatinine ratio (ACR) using spectrophotometric sequential injection analysis (SIA). Albumin was detected based on the dye-binding reaction.…”

Section: Introductionmentioning

confidence: 99%

Sequential Injection at Valve Mixing (SI-VM) for Determination of Albumin-Creatinine Ratio in Urine

Sabarudin¹

2018

Orient. J. Chem

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Measurement of the albumin-creatinine ratio (ACR) as a medical index of renal failure is imperative to identify individuals at high risk of kidney disease. The present study is aimed to develop albumin and creatinine measurement method by sequential injection at valve mixing (SI-VM) for the determination of urinary ACR. The laboratory-made SI-VM system consists of a syringe pump, 8-port selection valve, RGB-LED detector, and holding coil. This system was controlled by a computer using a home-made software prepared by the Visual Basic program. The detection of albumin was based on dye-binding of methyl orange, while the Jaffe reaction was applied for the creatinine detection. Both albumin and creatinine were simultaneously and automatically measured using SI-VM, and the absorbance was recorded at 530 nm. Some parameters affected sensitivity, precision, and accuracy of the method, which includes pH of methyl orange, the volume of albumin, the concentration of NaOH, NaOH-picric acid ratio, and flow rate to detector were studied in detail. The proposed method was successfully applied to the determination of ACR in urine samples with satisfied results. Additionally, a rapid, sensitive, and accurate determination of ACR could be attributed to the SI-VM method.

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Measurement of renal function in patients with chronic kidney disease

Cited by 70 publications

References 126 publications

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

The Course of Renal Function After Radical Cystectomy with Ileal Conduit Diversion for Bladder Cancer

Sequential Injection at Valve Mixing (SI-VM) for Determination of Albumin-Creatinine Ratio in Urine

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