Measurement of renal function in kidney donors using serum cystatin C and                   <i>β</i><sub>2</sub>-microglobulin

John, George T.; Fleming, Jude Joseph; Talaulikar, Girish; Selvakumar, R.; Thomas, Paulose P.; Jacob, C. K.

doi:10.1258/000456303770367252

Cited by 12 publications

(11 citation statements)

References 6 publications

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“…The authors suggest that cystatin C is more sensitive than creatinine as a marker of GFR reduction. A different conclusion was drawn by John et al [38], who, after 10 days in 28 kidney donors after nephrectomy, found GFR reduction, a 40% rise in creatinine concentration, and a 31% increase in cystatin C level. The authors think that cystatin C level shows high individual changeability and, therefore, it is not reliable to be used for the assessment of renal function impairment in these patients.…”

Section: Discussionmentioning

confidence: 78%

“…In the available literature we found no reports on the use of serum cystatin C level for the assessment of glomerular filtration in congenital solitary kidney patients. Rare reports have only described unilateral kidney patients after nephrectomy [37,38]. Kasiske et al [8], who conducted a meta-analysis of publications concerning the function of the only kidney after nephrectomy, concluded that the function is not impaired.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of serum cystatin C in children with congenital solitary kidney

et al. 2006

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The aim of the study was to assess serum cystatin C level in children with a congenital solitary kidney, depending on their age and compensatory overgrowth of the kidney. The study group (I) consisted of 36 children, 3-21 years of age (median 10.8 years), with a congenital solitary kidney and no other urinary defects. The control group (C) contained 36 healthy children, 5-21 years old (median 10.9 years). Nephelometric methods were used to determine serum cystatin C level, the Jaffe method to assess creatinine concentration and the Schwartz formula to estimate glomerular filtration rate. Kidney length was measured with the patient in a supine position, and overgrowth was estimated (O%) in comparison with the respective kidney in the control group. Serum cystatin C level in group I was higher than that in the control group (P<0.05). Increased values, above 0.95 mg/l, were found in 16/36 (44%) children aged 12-21 years. Glomerular filtration rate (GFR, estimated by the Schwartz formula) and creatinine level in group I were similar to those of the control group (P>0.05). Increased kidney length was found (median 18.2%). Cystatin C concentration was positively correlated with O% (r=0.406, P<0.01) and kidney length to child height ratio (L/H) (r=0.376, P<0.05). We conclude that Increased serum cystatin C concentration in patients with a unilateral congenital solitary kidney occurs after 12 years of age and correlates with compensatory overgrowth of the kidney.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Assessment of serum cystatin C in children with congenital solitary kidney

et al. 2006

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“…In addition, several previously published researches including Laterza et al [24], Le Bricon et al [25], Bianchi et al [26] and John et al [27] had concluded that serum cystatin C and beta2 microglobulin were easily applicable, highly sensitive indicators for AKI in their study when compared to routinely used serum creatinine.…”

Section: Discussionmentioning

confidence: 97%

Early Predictors of Acute Kidney Injury (AKI) in a Sample of Egyptian Full Term Neonates

El-Gamasy¹

2017

Med Clin Rev

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“…Some studies demonstrated the superiority of S. cystatin C compared with S.creatinine in the evaluation of GFR, especially when there is a minor reduction in GFR. [16171819] They found that S. cystatin C could detect renal dysfunction 1-2 days before S.creatinine. [20] However, other studies showed that S. cystatin C did not rise earlier than S. creatinine and was a poor biomarker for AKI.…”

Section: Introductionmentioning

confidence: 99%

Serum cystatin C is a poor biomarker for diagnosing acute kidney injury in critically-ill children

Hamed

El-Sherbini

Barakat

et al. 2013

Indian Journal of Critical Care Medicine

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Background:Accurate diagnosis of acute kidney injury (AKI) is problematic especially in critically-ill patients in whom renal function is in an unsteady state.Aim:Our aim was to evaluate the role of serum (S.) cystatin C as an early biomarker of AKI in critically-ill children.Subjects and Methods:S. creatinine and S. cystatin C were measured in 32 critically-ill children who were at risk for developing AKI. AKI was defined by both: Risk,-injury,-failure,-loss, and-endstage renal disease (RIFLE) classification and glomerular filtration rate (GFR) <80 ml/min/1.73 m2. GFR was estimated by both Schwartz formula and S. cystatin C-based equation.Results:S. cystatin C was not statistically higher in AKI patients compared with non-AKI by RIFLE classification (median 1.48 mg/l vs. 1.16 mg/l, P = 0.1) while S. creatinine was significantly higher (median 0.8 mg/dl vs. 0.4 mg/dl, P = 0.001). On estimating GFR by the two equations we found, a lag between rise of S. cystatin C and creatinine denoted by lower GFR by Schwartz formula in four patients, on other hand, six patients had elevated S. cystatin C with low GFR despite normal creatinine and GFR, denoting poor concordance between the two equations and the two markers. The ability of S. creatinine in predicting AKI was superior to S. cystatin with area under the curve (AUC) 0.95 with sensitivity and specificity (100% and 84.6%, respectively) using the RIFLE classification. The same findings were found when using Schwartz formula.Conclusion:S. cystatin C is a poor biomarker for diagnosing AKI in critically-ill children.

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Measurement of renal function in kidney donors using serum cystatin C and β₂-microglobulin

Abstract: Using critical values, serial measurement of serum creatinine was better than serum B2M in detecting reduced renal function. Because of its large intraindividual variation, serial serum cystatin C estimation was very poor in detecting reduced renal function.

Cited by 12 publications

References 6 publications

Assessment of serum cystatin C in children with congenital solitary kidney

Assessment of serum cystatin C in children with congenital solitary kidney

Early Predictors of Acute Kidney Injury (AKI) in a Sample of Egyptian Full Term Neonates

Serum cystatin C is a poor biomarker for diagnosing acute kidney injury in critically-ill children

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Measurement of renal function in kidney donors using serum cystatin C and β2-microglobulin

Abstract: Using critical values, serial measurement of serum creatinine was better than serum B2M in detecting reduced renal function. Because of its large intraindividual variation, serial serum cystatin C estimation was very poor in detecting reduced renal function.

Cited by 12 publications

References 6 publications

Assessment of serum cystatin C in children with congenital solitary kidney

Assessment of serum cystatin C in children with congenital solitary kidney

Early Predictors of Acute Kidney Injury (AKI) in a Sample of Egyptian Full Term Neonates

Serum cystatin C is a poor biomarker for diagnosing acute kidney injury in critically-ill children

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Measurement of renal function in kidney donors using serum cystatin C and β₂-microglobulin