Measurement of residual glomerular filtration rate in the patient receiving repetitive hemodialysis

Abstract

The objective of the current study was to determine the best index of residual glomerular filtration rate (GFR) by comparing simultaneously measured clearances of inulin, 125I-iothalamate, endogenous creatinine, urea and 169ytterbium diethylenetriaminepentaacetic acid (169YB-DTPA) in patients receiving repetitive hemodialysis. In patients with GFR less than 5 ml/min but greater than 1 ml/min, 125I-iothalamate clearance showed the best correlation with inulin clearance. However, creatinine clearance correlated better with inulin clearance than urea clearance and as well as urea + creatinine/2. In the patients with measured GFR less than 1 ml/min, the correlation of 125I-iothalamate, creatinine, urea and urea + creatinine/two clearances with inulin clearance was satisfactory. Similarly, satisfactory correlations were obtained when the relationships were examined across the entire range of measured clearances less than 5 ml/min. A simple, practical method is descriged for the accurate serial measurement of residual GFR in patients receiving repetitive dialysis.

Endogenous Markers for Estimation of Renal Function in Peritoneal Dialysis Patients

“…We found similar excretion of creatinine at the two visits, supporting the reproducibility of urine collections when patients are in a stable condition. Earlier, urine volume was proposed to be able to substitute for GFR, especially in follow-up studies (29), and urine volume has also recently been reported without clearance measurements (30,31). However, in the present study, urine volume was not correlated with cP-Cl(EDTA), U-Cl(EDTA), or eGFR(CysC).…”

Promoting Kidney Function Recovery in Patients with AKI Requiring RRT

“…In the outpatient setting, a 24-hour urine collection for urea and creatinine is commonly used to calculate residual GFR. This method has been examined in intermittent hemodialysis patients and shown to be as accurate as inulin clearance (91). Unfortunately, symptoms and signs of recovery are nonspecific (Table 2), but they should still be assessed and considered for their potential value as early indicators.…”

Iothalamate Quantification by Tandem Mass Spectrometry to Measure Glomerular Filtration Rate

“…Other studies however, suggest that iothalamate clearance is very tightly correlated with inulin clearance, whereas creatinine clearance consistently exceeds iothalamate clearance (6,15,16 ). As shown in Fig.…”