SUMMARY The echographic isovolumic contraction time (ICT) of the left ventricle (LV) was measured in order to assess alterations of LV performance in children with various forms of cardiac disease.The echographic ICT was defined as the interval between coaptation of the anterior and posterior mitral valve leaflets and aortic cusp opening. Four groups of patients were evaluated: normal (48); LV myocardial disease (20); patent ductus arteriosus (PDA) (19); and MEASUREMENTS DERIVED FROM THE ISO-VOLUMIC PHASE of left ventricular systole are sensitive to changes in the inotropic state of the myocardium.1 The duration of the isovolumic contraction time (ICT) of the left ventricle (LV) is one such measurement, and because of its physiological importance as an expression of the level of myocardial contractility, it would be desirable to have a reliable, noninvasive method of determining the length of the ICT.The ICT has been "classically" defined from closure of the mitral valve to the onset of LV ejection,2 3 and has been conventionally measured from the simultaneous, rapid speed recording of the electrocardiogram (ECG), the phonocardiogram, and the carotid pulse tracing.2' 3 The mitral component of the first heart sound (M1) has been employed as an index of mitral valve closure and the onset of LV ejection has been determined from the rapid upstroke of the carotid pulse tracing, which must then be corrected for the time delay of pulse transmission. Isovolumic contraction time has also been measured as the interval from the first to the second heart sound, minus the LV ejection time, obtained from the carotid pulse tracing.2A Despite technical difficulties in identifying M1, interest in determination of ICT has continued because the interval is less influenced by conduction abnormalities than are other measures of LV performance.3 Echocardiographically determined motion of the mitral and aortic valves5' 6 has been substituted here for the classical derivation of ICT from phonocardiograms and carotid pulse tracings. The interval from mitral leaflet coaptation to aortic cusp opening was defined as the echocardiographic ICT.This study was undertaken to measure echographic ICT in normal children and children with cardiac disease primarily affecting the LV, in order to test its sensitivity in detecting alterations of LV function. Methods Echocardiograms were recorded with a Hoffrel 101B or Unirad 100 series ultrasonoscope, employing either an Aerotech 5.0 MHz, unfocused (6 mm, external diameter) transducer, a 3.5 MHz, unfocused transducer, or a 2.25 MHz (6 mm) transducer, internally focused at 5 cm. The echographic tracing and ECG were recorded on a Cambridge or Irex physiological recorder at a paper speed of 75, 100, or 125 mm/sec. Timelines were 10 or 40 msec. The ECG lead which most clearly demonstrated early ventricular depolarization, usually the Q wave, was chosen for measuring the onset of electrical systole.The mitral valve echo was obtained from the left sternal border by standard techniques and mitral complexes wh...