Measurement of Serum EGF Levels, a Methodological Approach: Learning What Means “Low-/High-Concentration of EGF In Serum”. Some Clinical Implications

Idania, Gonzalez Perez; Hassiul, Caceres Lavernia Haslen; Adriana, Carr Perez; Kalet, Leon Monzon

doi:10.4172/2155-9929.1000335

J Mol Biomark Diagn

2017

DOI: 10.4172/2155-9929.1000335

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Measurement of Serum EGF Levels, a Methodological Approach: Learning What Means “Low-/High-Concentration of EGF In Serum”. Some Clinical Implications

Gonzalez Perez Idania¹,

Caceres Lavernia Haslen Hassiul²,

Carr Perez Adriana³

et al.

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Cited by 4 publications

References 41 publications

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Notable correlation between serum epidermal growth factor values and inflammatory status in patients with COVID‐19

Pérez,

Crombet

2024

Immunity Inflam & Disease

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IntroductionDespite its crucial role in Epidermal Growth Factor Receptor (EGFR) activation, and the resulting impact on the health‐disease process, epidermal growth factor (EGF) is an underexplored molecule in relation to how its serum concentrations relate to other analytes and clinical variables in pathological contexts.ObjectiveTo clarify the possible correlation between EGF and clinical and analytical variables in the context of COVID‐19.MethodsCross‐sectional observational and analytical study, in patients with virological and clinical diagnosis of COVID‐19, selected by simple random sampling, admitted between August and September 2021. UMELISA‐EGF commercial kits were used.ResultsDifferences in overall EGF values were observed between groups (566.04 vs. 910.53 pg/ml, p = .0430). In COVID‐19 patients, no notable correlations were observed for neutrophil, platelet, triglyceride or liver enzyme values (p > .05). Significant correlations were observed with the neutrophil‐lymphocyte indicator (r = 0.4711, p = .0128) as well as with the platelet‐lymphocyte index (r = 0.4553, p = .0155). Statistical results of multivariate regression analysis suggest NLR (β = .2232, p = .0353) and PLR (β = .2117, p = .0411) are predictors of inflammation in patients with COVID‐19.ConclusionsSerum EGF concentrations in COVID‐19 correlate positively with prognostic inflammatory markers of severity and could presumably act as an independent risk factor for the development of inflammation in response to new severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).

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Notable correlation between serum epidermal growth factor values and inflammatory status in patients with COVID‐19

Pérez,

Crombet

2024

Immunity Inflam & Disease

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Integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients: pilot study

et al. 2022

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Background Many variables have been studied in cancer patients. Nevertheless, an study that analyzes simultaneously physical, functional and biological variables in they from clinical, physical and statistical points of views is not reported in the literature. The aim of this study is to propose an integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients for the integral evaluation and possible prognostic of them. Methods This Pilot study was retrospective and cross-sectional and 23 patients aged 53–82 years participated in it. The electrical resistance and capacitive electrical reactance were measured with the Bodystat Quadscan® 4000 analyzer. The electrical impedance modulus and the phase angle were calculated. The serum concentrations of epidermal growth factor, CYFRA21-1 and CA 72–4 were quantified. Correlations/associations among variables and the principal component analysis were suggested. Results The majority of patients had tumor markers, electrical resistance and the phase angle in their respective normal ranges. The capacitive electrical resistance was below its normal range. Minimum, low and moderate grades of linear correlation/association prevailed among studied variables. The principal components I and II were interpreted as prognosis and body energetic reserve of the patient, respectively. Conclusions It is concluded that the clinical, bioelectrical and functional variables allow the integral analysis and possible prognosis of newly diagnosed lung cancer adult patients. The decrease of the capacitive electrical reactance is the most influence to the loss of the body energetic reserve that leads to alterations of the overall health, tiredness and decrease of weight and body mass index of these patients.

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Harmonization of Epidermal Growth Factor Measurements: Paving the Way of Finding A Biomarker in Non-Small Cell Lung Cancer

González-Pérez¹,

Monzón²

2016

Biosci., Biotech. Res. Asia

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Literature reports only a few contradictory findings regarding the capacity of serum EGF concentrations to differentiate between healthy individuals and patients suffering non-small cell lung cancer (NSCLC). Therefore, the possible diagnostic capacity of serum EGF levels, suggestive of dependency on this growth factor in NSCLC patients/tumors and hence indicative of possible response to therapies directed to EGF/EGFR, is controversial. Inconsistencies likely derive from the lack of harmonization and even standardization in methodologies for blood and sera processing. This manuscript is a mini-review of a recently published study, where the control of the key factors that influence the concentration of EGF in serum, along with the normalization of EGF concentrations by platelets count, allowed to clarify the diagnostic value of serum EGF levels. Several EGF-related variables were identified as potential biomarkers in NSCLC, particularly those normalized by platelets, which highlighted the differences between patients and controls. Additionally, the study revealed that NSCLC patients differ from healthy individuals not by the total stock of EGF, but by its higher accessibility to serum. The increase in free/accessible EGF in blood circulation is probably relevant to the biology of NSCLC, most likely because it reflects a higher accessibility to this tumoral growth factor.

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Measurement of Serum EGF Levels, a Methodological Approach: Learning What Means “Low-/High-Concentration of EGF In Serum”. Some Clinical Implications

Cited by 4 publications

References 41 publications

Notable correlation between serum epidermal growth factor values and inflammatory status in patients with COVID‐19

Notable correlation between serum epidermal growth factor values and inflammatory status in patients with COVID‐19

Integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients: pilot study

Harmonization of Epidermal Growth Factor Measurements: Paving the Way of Finding A Biomarker in Non-Small Cell Lung Cancer

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