Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Simon, Emmanuel; Callé, Samuel; Perrotin, Franck; Remeniéras, Jean-Pierre

doi:10.1371/journal.pone.0194309

Cited by 17 publications

(9 citation statements)

References 57 publications

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“…Moreover, we observe that values of celerities and parameter n are in the same order as values obtained with the previously developed plane shear wave TE method. 17 However, standard deviations found in the present study are higher than those with the previous method, not adapted for in vivo measurements. First, in the present 2D TE method, the shear wave is not a plane wave, as presented in Figs.…”

Section: Resultscontrasting

confidence: 73%

“…Preliminary results have been obtained using a 2-D Transient Elastography (TE) method based on the propagation of a plane shear wave generated by a plate fixed to a low frequency (LF) electromechanical actuator and measured using an ultrafast US scanner. 16,17 In the present work, we present ex vivo measurements of shear wave dispersion on normal human placentas with a new system dedicated to in vivo application.…”

Section: Introductionmentioning

confidence: 99%

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Shear wave velocity dispersion analysis in placenta using 2-D transient elastography

Callé

Simon

Dumoux

et al. 2018

Journal of Applied Physics

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Preeclampsia and intrauterine growth restriction are related to placental insufficiency and constitute a major public health challenge. Significant changes in placental microarchitecture have already been described in these situations, including, for example, increases or decreases in the number of villi ramifications and the presence of fibrin deposits in terms of villi. These changes affect the entire placenta and might lead to variations in elasticity compared to normal placentas. In this context, we proposed to develop a 2-D transient elastography system, dedicated to the placenta and adapted for in vivo measurements, based on the coupling of a shear wave generated by an external vibration and ultrasound images acquired at an ultrafast rate. To be particularly sensitive to the structure of this organ, a frequency analysis of the complex shear modulus has been realized by applying a fractional rheological model. This model provides a parameter n which could be sensitive to a shape factor, for example, the variations in the number of villi ramifications in the case of placental insufficiency. An ex vivo feasibility of the method on 20 normal placentas is presented in this work.

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Section: Resultscontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Shear wave velocity dispersion analysis in placenta using 2-D transient elastography

Callé

Simon

Dumoux

et al. 2018

Journal of Applied Physics

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“…LOX, lysyl oxidase; LOXL-1, lysyl oxidase-like 1; CVD, chronic venous disease; HC, healthy controls; RT-qPCR, reverse transcription-quantitative PCR. of the placenta and to develop techniques to evaluate its state under multiple conditions (39). The results from the present study showed that there was variation in the expression level of TE, as well as in the different components of ECM, such as FBLN-4, FBN-1 and the lysyl oxidase family (LOX and LOXL-1).…”

Section: Discussionmentioning

confidence: 66%

“…These fibers are essential for providing tissues with elastic properties, as well as for regulating the bioavailability of components, such as TGF-β, and alterations in this system arise in a wide variety of inherited or acquired pathologies, such as Marfan or cancer ( 37 , 38 ). It is important to investigate the elasticity of the placenta and to develop techniques to evaluate its state under multiple conditions ( 39 ). The results from the present study showed that there was variation in the expression level of TE, as well as in the different components of ECM, such as FBLN-4, FBN-1 and the lysyl oxidase family (LOX and LOXL-1).…”

Section: Discussionmentioning

confidence: 99%

An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

et al. 2021

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Chronic venous disease (CVD) is the response to a series of hemodynamic changes in the venous system and the onset of this disease is often triggered by pregnancy. Placental tissue is particularly sensitive to the characteristic changes which occurs in venous hypertension. In this regard, changes in the extracellular matrix (ECM), that occur to adapt to this situation, are fundamental to controlling elastogenesis. Therefore, the aim of the present study was to analyze the changes that occur in the mRNA and protein expression level of proteins related to elastogenesis in the placental villi of women diagnosed with CVD, in the third trimester of pregnancy. An observational, analytical and prospective cohort study was conducted, in which the placenta from 62 women with CVD were compared with that in placenta from 52 women without a diagnosis of CVD. Gene and protein expression levels were analyzed using reverse transcription-quantitative PCR and immunohistochemistry, respectively. The results showed a significant decrease in the gene and protein expression level of EGFL7 in the placental villi of women with CVD. By contrast, significant increases in the gene and protein expression level of ECM-related proteins, such as tropoelastin, fibulin 4, fibrillin 1 and members of the lysyl oxidase family (LOX and LOXL-1) were also found in the placental villi of women with CVD. To the best of our knowledge, the results from the present study showed for the first time that CVD during pregnancy was associated with changes in the mRNA and protein expression level in essential components of the EGFL7-modulated elastogenesis process in placental villi.

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“…Simon and colleagues discovered that preeclampsia patients have much increased placental stiffness, and that placenta elasticity has a strong link with Doppler indices of the uterine, umbilical, and middle cerebral arteries. In recent years, imaging techniques based on elastography have received a lot of attention for non-invasive examination of tissue mechanical characteristics 24 . The tissue stiffness response after application of mechanical force is measured in dedicated imaging modes 25 .…”

Section: Discussionmentioning

confidence: 99%

Placental Elasticity (KPA) Assessment by Shearwave Elastography in early detection of hypotrophic fetuses.

Butt¹,

Gilani²,

Hanif³

et al. 2021

PJMHS

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Aim: To see the predictability of the shear wave elastography assessment of placental elasticity (kpa) for early detection of hypotrophic fetuses Design: Cross sectional comparative.300 single tone pregnancies previously diagnosed as normal and hypotrophic fetuses were included, the placental elasicity assessed by shear wave elastography of both groups and compared. Methods: We took biometric measurements and Doppler indicis of the uterine, umbilical, and middle cerebral arteries in both groups and screened them for grayscale and colour doppler ultrasonography. The placental elasticity was measured by Shear wave elastography in these groups .The comparison of strain ratios between these groups were done. Statistical analysis was carried out using the Mann-Whitney test. By plotting ROC curves, cut-off values for elasticity were analysed. On Shear wave elastography measurements, the sensitivity and specificity and diagnostic accuracy of hypotrophic fetuses were planned and developed. Results: The mean placental elasticity in hypotrophic fetuses and normal group was 28.71 ± 7.28 and 5.64 ± 1.53 respectively while the median placental elasticity in IUGR group was 27 ± 7 and 5.50 ± 2 with statistically higher median in hypotrophic groups, p-value < 0.001. Conclusion: In hypotrophic fetuses, as placental stiffness values are much higher, therefore for early detection of compromised hypotrophic fetuses , as a non-invasive, supplementary tool to gray-scale and Doppler, the Shear-wave elastography can be used. Keywords: Hypotrophic fetuses, Shear-wave elastography, Placental Elasticity (kpa), IUGR, Uterine artery, Umbilical artery, Middle cerebral artery, resistive index, pulsatility index,

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Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Cited by 17 publications

References 57 publications

Shear wave velocity dispersion analysis in placenta using 2-D transient elastography

Shear wave velocity dispersion analysis in placenta using 2-D transient elastography

An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

Placental Elasticity (KPA) Assessment by Shearwave Elastography in early detection of hypotrophic fetuses.

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