Measurement of single kidney contrast media clearance by multiphasic spiral computed tomography: preliminary results

Comparison of Mathematic Models for Assessment of Glomerular Filtration Rate with Electron-Beam CT in Pigs

“…Previous study results have demonstrated the applicability and reproducibility of estimating GFR on electron-beam (EB) CT images with a gamma variate model; applicability and reproducibility were validated by means of comparison with a reference standard (3,4). The feasibility of the graphic model described by Patlak and Blasberg (5) for estimation of GFR from renal time-attenuation curves (TACs) has also been demonstrated (6)(7)(8)(9)(10)(11); however, its application mandates further consideration of the anatomic and functional heterogeneity of the kidney. In previous studies, regions of interest (ROIs) encompassed the entire kidney, including the medulla, which is not physiologically involved in glomerular filtration (6,8,9,11).…”

“…The feasibility of the graphic model described by Patlak and Blasberg (5) for estimation of GFR from renal time-attenuation curves (TACs) has also been demonstrated (6)(7)(8)(9)(10)(11); however, its application mandates further consideration of the anatomic and functional heterogeneity of the kidney. In previous studies, regions of interest (ROIs) encompassed the entire kidney, including the medulla, which is not physiologically involved in glomerular filtration (6,8,9,11). To our knowledge, GFR, as derived with the model of Patlak and Blasberg, has not been directly compared with inulin clearance (7,8,12).…”

Measuring Single-Kidney Glomerular Filtration Rate on Single-Detector Helical CT Using a Two-Point Patlak Plot Technique in Patients with Increased Interstitial Space

“…The Patlak plot technique is based on a two-compartment pharmacokinetic model in which the transfer of contrast medium to the second compartment is unilateral and nonreversible. The technique was first described by Rutland [3] in 1979 for perfusion and background correction in renal scintigraphy.In the past, glomerular filtration rate (GFR) was measured with the Patlak plot based on single-location dynamic CT, which resulted in GFR per milliliter of renal parenchyma [4][5][6].In two preceding studies [7,8], we introduced a two-point Patlak plot technique based on one unenhanced and two enhanced single-detector helical CT scans of the entire kidneys, hereinafter referred to as CT GFR. CT GFR gives GFR values for the left kidney and the right kidney in milliliters per minute.…”

Glomerular Filtration Rate measurement based on multiphasic helical CT images with three-compartment model

“…In recent years, there are some studies on CT GFR measurement method [1][2][3][4][5][6][7][8][9][10][11]. Since Computed Tomography (CT) offers the capability to measure non-invasively changes in concentration of contrast material, it becomes possible to measure GFR based on functional renal imaging.…”

“…Hackstein et al [4,5] introduced a two-point Patlak plot technique based on one unenhanced and two enhanced singledetector helical CT scans of the entire kidneys. This technique is based on a two-compartment model with unilateral tracer transport from compartment 1 into compartment 2 and was first introduced by Rutland [6] in 1979 for background and perfusion correction in renal scintigraphy.…”