Measurement of spleen volume is useful for distinguishing between simple steatosis and early‐stage non‐alcoholic steatohepatitis

Suzuki, Kaori; Kohno, Hiroyuki; Yoneda, Masato; Mawatari, Hironori; Fujita, Koji; Nozaki, Yuichi; Takahashi, Hirokazu; Abe, Yasunobu; Inamori, Masahiko; Shimamura, Takeshi; Kobayashi, Noritoshi; Kubota, Kensuke; Saito, Satoru; Nakajima, Atsushi

doi:10.1111/j.1872-034x.2010.00643.x

Cited by 34 publications

(26 citation statements)

References 31 publications

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“…Data of previous studies suggest that clues of AST aspartate aminotransferase, ALT alanine aminotransferase * Student T test steatohepatitis in NAFLD patients can be an increase in portal vein diameter, reduction of portal vein velocity, large splenic area, and an increase in RI of splenic artery [10,15,16]. In our baseline, similar characteristics were found in NAFLD patients with severe fatty liver disease (Table 2).…”

Section: Discussionsupporting

confidence: 81%

Hepatic artery resistive index (HARI) and non-alcoholic fatty liver disease (NAFLD) fibrosis score in NAFLD patients: cut-off suggestive of non-alcoholic steatohepatitis (NASH) evolution

Tana

Tana²,

Rossi

et al. 2016

J Ultrasound

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Purpose of the study Conventional ultrasound (US) is reliable to reveal the presence of non-alcoholic fatty liver disease (NAFLD), but it is neither sensitive nor specific to reveal fibrosis clues, except in advanced stages where signs of cirrhosis are evident. NALFD fibrosis score is a noninvasive parameter that predicts well the presence of significant fibrosis, but correlations with US parameters are lacking. The aim of this study was, therefore, to compare resistive index of hepatic artery (HARI) of NAFLD patients with different severity degrees of diffuse fatty liver disease vs HARI of controls, and to compare HARI of NAFLD patients with different NAFLD fibrosis scores vs HARI of controls. Methods This was a spontaneous, no-profit observational study conducted in our US department between December 2013 and July 2014. Patients with NAFLD with different severity of disease and healthy controls were included. Echogenicity and size of liver and spleen, maximum portal vein velocity, RI, peak systolic velocity (PSV), and end diastolic velocity (EDV) of splenic artery, PSV, EDV, and RI of hepatic artery, and NAFLD fibrosis score were acquired and compared between groups.Results HARI was significantly lower in NAFLD patients than controls (p \ 0.0001). A significant difference was also found between the groups of NAFLD severity (p \ 0.0001). There was also a difference between HARI of NAFLD patients with different NAFLD fibrosis scores vs HARI of controls (p \ 0.0001) with a positive correlation between HARI and NAFLD fibrosis score. Conclusion and discussion Conventional Doppler US can be helpful to detect NAFLD patients with the risk of fibrous tissue accumulation. HARI tends to exceed the range of controls for patients with NAFLD fibrosis score greater than 0.675. The detection of HARI greater than 0.9 in NAFLD patients, regardless of the US degree of severity of steatosis, might suggest the execution of biopsy to predict the risk of progression to steatohepatitis and fibrous tissue accumulation. Low values of HARI may be expression of lower risk, which does not necessitate any biopsy.Keywords Hepatic artery resistive index Á Non-alcoholic fatty liver disease Á NAFLD fibrosis score Á Non-alcoholic steatohepatitis Á Ultrasound Á Color Doppler Sommario Scopo dello studio L'ecografia convenzionale è risultata affidabile nel rilevare la presenza di steatosi epatica, tra cui la forma non alcolica (NAFLD), ma non è né sensibile né specifica nel rivelare indizi suggestivi di fibrosi, tranne che in fase avanzata dove sono presenti segni conclamati di cirrosi. Il NALFD fibrosis score è un parametro non invasivo che predice bene la presenza di fibrosi significativa, ma non ci sono dati in letteratura riguardanti una possibile correlazione con i parametri ecografici. Lo scopo di questo studio è stato quindi quello di confrontare HARI dei pazienti con NAFLD a differente grado di severità di steatosi epatica vs l'HARI dei controlli, e di confrontare HARI dei pazienti affetti da NAFLD a differente NAFLD fibrosis score...

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Section: Discussionsupporting

confidence: 81%

Hepatic artery resistive index (HARI) and non-alcoholic fatty liver disease (NAFLD) fibrosis score in NAFLD patients: cut-off suggestive of non-alcoholic steatohepatitis (NASH) evolution

Tana

Tana²,

Rossi

et al. 2016

J Ultrasound

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“…In the current study a statistically highly significant positive correlation existedbetween the degree of steatosis and size of the spleen. This was in agreement with Suzukiet al, who found larger splenic size in patients with simple steatosis and NASH (16) . There are reports which had suggested that enlarged hepatocytes arising from steatosiscompress the sinusoids and lead to portal hypertension in NASH patients (17) .…”

Section: Discussionsupporting

confidence: 82%

“…Similarly, Mendes et alperformed a study on patients of NASH with no fibrosis and found that (6%) of patientswith steatosis had portal hypertension (5) . It is of notice that changes in liver blood flow in steatosis partly resemble thoseseen in cirrhosis, in which the intra-hepatic portal flow is usually reduced attributed to anincreased intrahepatic vascular resistance resulting in increase in the portal pressure (16) . In the current study a statistically highly significant positive correlation existedbetween the degree of steatosis and size of the spleen.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease (NAFLD) and Portal Hypertension in Egyptian Patients

Maher¹

2016

jmscr

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“…In NASH (as occurs with alcoholic liver disease), fibrosis begins around the central veins; therefore, the symptoms of portal hypertension are thought to appear first as a result of central vein occlusion [28,29]. The spleen volume is speculated to increase as the portal blood pressure increases in chronic liver disease [30], and we previously reported that splenic enlargement may be a distinct feature of NASH [31].…”

Section: Discussionmentioning

confidence: 97%

Platelet count for predicting fibrosis in nonalcoholic fatty liver disease

et al. 2011

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Measurement of spleen volume is useful for distinguishing between simple steatosis and early‐stage non‐alcoholic steatohepatitis

Abstract: Spleen enlargement may be a distinct feature of NASH, especially early-stage NASH. SBI might be a non-invasive and simple method of differentiating NASH and simple steatosis.

Cited by 34 publications

References 31 publications

Hepatic artery resistive index (HARI) and non-alcoholic fatty liver disease (NAFLD) fibrosis score in NAFLD patients: cut-off suggestive of non-alcoholic steatohepatitis (NASH) evolution

Hepatic artery resistive index (HARI) and non-alcoholic fatty liver disease (NAFLD) fibrosis score in NAFLD patients: cut-off suggestive of non-alcoholic steatohepatitis (NASH) evolution

Nonalcoholic fatty liver disease (NAFLD) and Portal Hypertension in Egyptian Patients

Platelet count for predicting fibrosis in nonalcoholic fatty liver disease

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