Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method

Fung, Francis H Y; Tang, Jonathan; Hopkins, John P P; Dutton, John; Bailey, Lisa M.; Davison, Andrew S.

doi:10.1258/acb.2012.011257

Cited by 25 publications

(20 citation statements)

References 33 publications

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“…The comparability between this immunoassay, the QMS ® teicoplanin, and our newly developed LC-MS method is moderate. However, the correlation coefficient r = 0.856 (r 2 = 0.73) observed by us resembles the previously reported correlation between teicoplanin measurements by another LC-MS method and FPIA (r 2 = 0.86) [19]. Possible reasons for the relatively poor correlations include different cross-reactivities of the antibodies with the different teicoplanins as well as interferences with the immunoassay.…”

Section: Discussionsupporting

confidence: 84%

“…To the best of our knowledge, there are currently only two other published applications of LC-MS to TDM of teicoplanin [19,20]. Our method is the first method using online extraction based on turbulent flow chromatography.…”

Section: Discussionmentioning

confidence: 99%

“…Several analytical methods are available for therapeutic drug monitoring (TDM) of teicoplanin in serum or plasma: fluorescence polarization immunoassays (FPIA) [13], homogeneous turbidimetric immunoassays [14], high-performance liquid chromatography (HPLC) [15][16][17][18], and liquid chromatography coupled to mass spectrometry (LC-MS) [19,20], all of them having their advantages and disadvantages. Compared with immunological methods, chromatographic methods usually are less susceptible to interferences.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS® assay

Müller

Eckardstein

Saleh

2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS® assay

Müller

Eckardstein

Saleh

2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The existing available methods for assaying TCP are high-performance liquid chromatography (HPLC), microbiological assay and liquid chromatography-mass spectrometry. [6][7][8] Among them, HPLC is the main measurement method for TCP because of its high separation e±ciency and good selectivity. However, these methods involve a tedious variety of reagents or lengthy run times, which are unsuitable for rapid measurement of TCP in the production process or in blood.…”

Section: Introductionmentioning

confidence: 99%

AO–MW–PLS method applied to rapid quantification of teicoplanin with near-infrared spectroscopy

Chen

Pan

et al. 2017

J. Innov. Opt. Health Sci.

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Teicoplanin (TCP) is an important lipoglycopeptide antibiotic produced by fermenting Actinoplanes teichomyceticus. The change in TCP concentration is important to measure in the fermentation process. In this study, a reagent-free and rapid quanti¯cation method for TCP in the TCP-Tris-HCl mixture samples was developed using near-infrared (NIR) spectroscopy by focusing our attention on the fermentation process for TCP. The absorbance optimization (AO) partial least squares (PLS) was proposed and integrated with the moving window (MW) PLS, which is called AO-MW-PLS method, to select appropriate wavebands. A model set that includes various wavebands that were equivalent to the optimal AO-MW-PLS waveband was proposed based on statistical considerations. The public region of all equivalent wavebands was just one of the equivalent wavebands. The obtained public regions were 1540-1868 nm for TCP and 1114-1310 nm for Tris. The root-mean-square error and correlation coe±cient for leave-oneout cross validation were 0.046 mg mL À1 and 0.9998 mg mL À1 for TCP, and 0.235 mg mL À1 and 0.9986 mg mL À1 for Tris, respectively. All the models achieved highly accurate prediction e®ects, and the selected wavebands provided valuable references for designing specialized spectrometers. This study provided a valuable reference for further application of the proposed methods to TCP fermentation broth and to other spectroscopic analysis¯elds.

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“…Mass transitions determined to be suitable for the quantitation of teicoplanin (940.6 m/z → 316.5 m/z, and 940.6 m/z → 298.3 m/z) were consistent with the literature. 13 Erythromycin was used as an internal standard (734.5 m/z → 158.5 m/z, and 734.5 m/z → 576.9 m/z). Analytes were separated on an Alltech™ Alltima™ Reversed-Phase HPLC Column, 20 mm × 2.1 mm, with 3 μm particles.…”

Section: Serum Teicoplanin Concentrationsmentioning

confidence: 99%

A multi-centre, phase IV study to evaluate the steady-state plasma concentration and serum bactericidal activity of a generic teicoplanin preparation

Greeff

Tonder

Cromarty

et al. 2015

Southern African Journal of Infectious Diseases

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Introduction:Teicoplanin is an effective treatment option against methicillin-resistant, Gram-positive bacteria, like Staphylococcus aureus. It is a glycopeptide antibiotic, produced through microbial fermentation, a process resulting in variations in the N-acyl side chain. Concerns that these variations may affect the pharmacokinetic profile and the clinical efficacy of generic teicoplanin preparations have been raised. Method: To address this issue, a multi-centre observational study was conducted to evaluate steady-state peak and trough serum concentrations, and the serum bactericidal activity (SBA) and safety of a generic teicoplanin preparation in critically ill patients. Additionally, the composition of the generic teicoplanin was compared to that of the innovator drug to assess differences in the composition. Results: Following pre-determined loading and maintenance dose schedules, the mean peak and trough teicoplanin serum concentrations were 20.98 mg/l and 10.38 mg/l, respectively. A statistically significant association was observed between teicoplanin pharmacotherapy and increased ex vivo SBA. It was found using independent analysis that the composition of the generic teicoplanin preparation was similar to that of the innovator drug, and that both formulations met the European Pharmacopoeia specifications. Conclusion:The loading and maintenance schedules employed in this study were effective in establishing therapeutic serum teicoplanin concentrations in critically ill patients. Evidence of bactericidal activity measured in patients' ex vivo serum samples, following treatment with the generic preparation, supports this finding.

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Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method

Cited by 25 publications

References 33 publications

Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS® assay

Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS® assay

AO–MW–PLS method applied to rapid quantification of teicoplanin with near-infrared spectroscopy

A multi-centre, phase IV study to evaluate the steady-state plasma concentration and serum bactericidal activity of a generic teicoplanin preparation

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