Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with<sup>99m</sup>Tc-DTPA Autoradiography in Rats

Arheden, Håkan; Saeed, Maythem; Higgins, Charles B.; Gao, Dong-Wei; Bremerich, Jens; Wyttenbach, Rolf; Dae, Michael W.; Wendland, Michael F.

doi:10.1148/radiology.211.3.r99jn41698

Cited by 313 publications

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“…a: Longitudinal magnetization recovery curves for the case in which the CA has access to the injured myocardium. This region is enhanced due to a larger distribution volume for CA (4,5,7,13). b: Longitudinal magnetization recovery curves for the case in which the CA does not have access to the injured myocardium (as in the present study).…”

Section: Discussionmentioning

confidence: 70%

“…This region is enhanced due to a larger distribution volume of the CA (4,5,7,13), and therefore a relatively higher relaxation rate, compared to blood and viable perfused myocardium. However, if no CA enters the injured myocardium, the T 1 relaxation curves have a different appearance (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…This imaging technique relies on R 1 (1/T 1 ) differences between infarcted and viable perfused myocardia after administration of an extracellular gadolinium-(Gd)-based contrast agent (CA). The contrast between infarcted and viable myocardia is enhanced using an inversion recovery sequence (3)(4)(5)(6)(7)(8). For this sequence the inversion time (TI) is set to null the signal from perfused myocardium, which then becomes black in the image while the infarcted myocardium becomes hyperintense (enhanced).…”

mentioning

confidence: 99%

“…For this sequence the inversion time (TI) is set to null the signal from perfused myocardium, which then becomes black in the image while the infarcted myocardium becomes hyperintense (enhanced). It has been suggested that enhancement of infarcted myocardium may be due to higher concentrations of extracellular CA in this region caused by delayed wash-in and wash-out kinetics (9 -12), as well as to different distribution volumes (4,5,7,13) between infarcted and viable perfused myocardia. Furthermore, it has been shown that extracellular Gd-based MR CAs do not bind to the injured myocardium, and therefore binding does not contribute to the effect of late enhancement (14).…”

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confidence: 99%

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Importance of perfusion in myocardial viability studies using delayed contrast‐enhanced magnetic resonance imaging

Hedström¹,

Arheden²,

Eriksson³

et al. 2006

Magnetic Resonance Imaging

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Purpose:To investigate whether an extracellular gadolinium-(Gd)-based contrast agent (CA) enters nonperfused myocardium during acute coronary occlusion, and whether nonperfused myocardium presents as hyperintense in delayed contrast-enhanced (DE) MR images in the absence of CA in that region. Materials and Methods:The left anterior descending coronary artery (LAD) was occluded for 200 minutes in six pigs. The longitudinal relaxation rate (R 1 ) in blood, perfused myocardium, and nonperfused myocardium was repeatedly measured using a Look-Locker sequence before and during the first hour after administration of Gd-DTPA-BMA.Results: While blood and perfused myocardium showed a major increase in R 1 after CA administration, nonperfused myocardium did not. R 1 in nonperfused myocardium was significantly lower than in blood and perfused myocardium during the first hour after CA administration. When the signal from perfused myocardium was nulled, demarcation of the hyperintense nonperfused myocardium was achieved in all of the study animals. Conclusion:Gd-DTPA-BMA does not enter ischemic myocardium within one hour after administration during acute coronary occlusion. The ischemic region with complete absence of CA still appears bright when the signal from perfused myocardium is nulled using inversionrecovery DE-MRI. This finding is important for understanding the basic pathophysiology of inversion-recovery viability imaging, as well as for imaging of acute coronary syndromes.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Importance of perfusion in myocardial viability studies using delayed contrast‐enhanced magnetic resonance imaging

Hedström¹,

Arheden²,

Eriksson³

et al. 2006

Magnetic Resonance Imaging

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“…A commercially available extracellular gadolinium-based contrast agent (gadoteric acid, Gd-DOTA, Guerbet, Gothia Medical AB, Billdal, Sweden) was administered intravenously (0.2 mmol/kg) 30 ± 9 (SD) minutes before image acquisition. DE-MRI using the IR-GRE sequence utilizes an increase in regional fractional distribution of extracellular MRI contrast media within the injured area to achieve contrast between infarcted and non-infarcted myocardium (17)(18)(19)(20). The inversion time (TI) was adjusted to null the signal from the non-infarcted myocardium.…”

Section: Study Protocolmentioning

confidence: 99%

Size and transmural extent of first-time reperfused myocardial infarction assessed by cardiac magnetic resonance can be estimated by 12-lead electrocardiogram

Engblom

Hedström

Heiberg

et al. 2005

American Heart Journal

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Comprehensive Cardiovascular Magnetic Resonance Tissue Characterization and Cardiotoxicity in Women With Breast Cancer

et al. 2023

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ImportanceThere is a growing interest in understanding whether cardiovascular magnetic resonance (CMR) myocardial tissue characterization helps identify risk of cancer therapy–related cardiac dysfunction (CTRCD).ObjectiveTo describe changes in CMR tissue biomarkers during breast cancer therapy and their association with CTRCD.Design, Setting, and ParticipantsThis was a prospective, multicenter, cohort study of women with ERBB2 (formerly HER2)–positive breast cancer (stages I-III) who were scheduled to receive anthracycline and trastuzumab therapy with/without adjuvant radiotherapy and surgery. From November 7, 2013, to January 16, 2019, participants were recruited from 3 University of Toronto–affiliated hospitals. Data were analyzed from July 2021 to June 2022.ExposuresSequential therapy with anthracyclines, trastuzumab, and radiation.Main Outcomes and MeasuresCMR, high-sensitivity cardiac troponin I (hs-cTnI), and B-type natriuretic peptide (BNP) measurements were performed before anthracycline treatment, after anthracycline and before trastuzumab treatment, and at 3-month intervals during trastuzumab therapy. CMR included left ventricular (LV) volumes, LV ejection fraction (EF), myocardial strain, early gadolinium enhancement imaging to assess hyperemia (inflammation marker), native/postcontrast T1 mapping (with extracellular volume fraction [ECV]) to assess edema and/or fibrosis, T2 mapping to assess edema, and late gadolinium enhancement (LGE) to assess replacement fibrosis. CTRCD was defined using the Cardiac Review and Evaluation Committee criteria. Fixed-effects models or generalized estimating equations were used in analyses.ResultsOf 136 women (mean [SD] age, 51.1 [9.2] years) recruited from 2013 to 2019, 37 (27%) developed CTRCD. Compared with baseline, tissue biomarkers of myocardial hyperemia and edema peaked after anthracycline therapy or 3 months after trastuzumab initiation as demonstrated by an increase in mean (SD) relative myocardial enhancement (baseline, 46.3% [16.8%] to peak, 56.2% [18.6%]), native T1 (1012 [26] milliseconds to 1035 [28] milliseconds), T2 (51.4 [2.2] milliseconds to 52.6 [2.2] milliseconds), and ECV (25.2% [2.4%] to 26.8% [2.7%]), with P &lt;.001 for the entire follow-up. The observed values were mostly within the normal range, and the changes were small and recovered during follow-up. No new replacement fibrosis developed. Increase in T1, T2, and/or ECV was associated with increased ventricular volumes and BNP but not hs-cTnI level. None of the CMR tissue biomarkers were associated with changes in LVEF or myocardial strain. Change in ECV was associated with concurrent and subsequent CTRCD, but there was significant overlap between patients with and without CTRCD.Conclusions and RelevanceIn women with ERBB2-positive breast cancer receiving sequential anthracycline and trastuzumab therapy, CMR tissue biomarkers suggest inflammation and edema peaking early during therapy and were associated with ventricular remodeling and BNP elevation. However, the increases in CMR biomarkers were transient, were not associated with LVEF or myocardial strain, and were not useful in identifying traditional CTRCD risk.

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Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with^99mTc-DTPA Autoradiography in Rats

Cited by 313 publications

References 42 publications

Importance of perfusion in myocardial viability studies using delayed contrast‐enhanced magnetic resonance imaging

Importance of perfusion in myocardial viability studies using delayed contrast‐enhanced magnetic resonance imaging

Size and transmural extent of first-time reperfused myocardial infarction assessed by cardiac magnetic resonance can be estimated by 12-lead electrocardiogram

Comprehensive Cardiovascular Magnetic Resonance Tissue Characterization and Cardiotoxicity in Women With Breast Cancer

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Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with99mTc-DTPA Autoradiography in Rats

Cited by 313 publications

References 42 publications

Importance of perfusion in myocardial viability studies using delayed contrast‐enhanced magnetic resonance imaging

Importance of perfusion in myocardial viability studies using delayed contrast‐enhanced magnetic resonance imaging

Size and transmural extent of first-time reperfused myocardial infarction assessed by cardiac magnetic resonance can be estimated by 12-lead electrocardiogram

Comprehensive Cardiovascular Magnetic Resonance Tissue Characterization and Cardiotoxicity in Women With Breast Cancer

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Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with^99mTc-DTPA Autoradiography in Rats