Measurement of the elasticity modulus of soft tissues

Zörner, Stefan; Lerch, Reinhard; Sutor, Alexander; Döllinger, Michael

doi:10.1016/j.jbiomech.2010.01.035

Cited by 20 publications

(17 citation statements)

References 21 publications

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“…By collecting as much as possible information about a single model system (such as for example the rat), the combination of destructive techniques which provide more direct measures and non-destructive techniques (e.g. Daley et al, 2007; Hertegard et al, 2009, Zörner et al, 2010) which require separate methods to determined important variables, for example Poisson’s ratio, might eventually allow to establish reliable and robust correlations which require no or little assumptions.…”

Section: Discussionmentioning

confidence: 99%

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Elasticity and stress relaxation of a very small vocal fold

Riede

York

Furst

et al. 2011

Journal of Biomechanics

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Across mammals many vocal sounds are produced by airflow induced vocal fold oscillation. We tested the hypothesis that stress-strain and stress-relaxation behavior of rat vocal folds can be used to predict the fundamental frequency range of the species’ vocal repertoire. In a first approximation vocal fold oscillation has been modeled by the string model but it is not known whether this concept equally applies to large and small species. The shorter the vocal fold, the more the ideal string law may underestimate normal mode frequencies. To accommodate the very small size of the tissue specimen, a custom-built miniaturized tensile test apparatus was developed. Tissue properties of 6 male rat vocal folds were measured. Rat vocal folds demonstrated the typical linear stress-strain behavior in the low strain region and an exponential stress response at strains larger than about 40%. Approximating the rat’s vocal fold oscillation with the string model suggests that fundamental frequencies up to about 6 kHz can be produced, which agrees with frequencies reported for audible rat vocalization. Individual differences and time-dependent changes in the tissue properties parallel findings in other species, and are interpreted as universal features of the laryngeal sound source.

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Section: Discussionmentioning

confidence: 99%

“…Some tests have been suggested to measure stress in small samples (e.g. Daley et al, 2007; Hertegard et al, 2009, Zörner et al, 2010). However, these techniques are not designed to measure tensile strain and results are therefore not directly comparable to data collected in other species.…”

Section: Introductionmentioning

confidence: 99%

Elasticity and stress relaxation of a very small vocal fold

Riede

York

Furst

et al. 2011

Journal of Biomechanics

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“…3, was based on that of [53]. In our study, an aluminum annulus-shaped pipette was used, the bottom surface of which was gently pressed against the surface of the specimen.…”

Section: Methodsmentioning

confidence: 99%

“…These studies show the suitability of the pipette aspiration technique for material property investigations of both synthetic and biological soft tissues. Zoerner et al [53] extended the capability of this technique to include a fluctuating pressure, thereby enabling frequency-dependent measurements. This was done by replacing the static suction pressure in the original setup of [46] with a fluctuating pressure.…”

Section: Introductionmentioning

confidence: 99%

Pipette aspiration applied to the characterization of nonhomogeneous, transversely isotropic materials used for vocal fold modeling

Weiß

Thomson

Lerch

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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The etiology and treatment of voice disorders are still not completely understood. Since the vibratory characteristics of vocal folds are strongly influenced by both anatomy and mechanical material properties, measurement methods to analyze the material behavior of vocal fold tissue are required. Due to the limited life time of real tissue in the laboratory, synthetic models are often used to study vocal fold vibrations. In this paper we focus on two topics related to synthetic and real vocal fold materials. First, because certain tissues within the human vocal folds are transversely isotropic, a fabrication process for introducing this characteristic in commonly-used vocal fold modeling materials is presented. Second, the pipette aspiration technique is applied to the characterization of these materials. By measuring the displacement profiles of stretched specimens that exhibit varying degrees of transverse isotropy, it is shown that local anisotropy can be quantified using a parameter describing the deviation from an axisymmetric profile. The potential for this technique to characterize homogeneous, anisotropic materials, including soft biological tissues such as those found in the human vocal folds, is supplemented by a computational study.

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“…This can be ascribed to the Young's modulus, which is higher for mixture 111 than for 113 (Table 1). However, it is impossible to find a constant material parameter set (independent of the excitation frequency) describing the frequency resolved transfer function in an appropriate way (e.g., [35,36,38]). Thus, the characterization of the mechanical properties with respect to the frequency is indispensable.…”

Section: Methodsmentioning

confidence: 99%