The cross section for the neutron-induced fission of 238U nuclei has been measured using the time-of-flight spectrometer of the GNEIS neutron complex at the Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, in the neutron energy range of 0.3–500 MeV. Fission fragments have been detected by low-pressure position-sensitive multiwire proportional counters. The cross section for 238U(n, f) fission has been measured with respect to the cross section for 235U(n, f) fission, which is an accepted international standard. Data on the energy dependence of the anisotropy of the angular distribution of fragments of neutron-induced 238U nuclei are also presented. The data obtained have been compared to previous experiments carried out using both similar and significantly different methods.