The DArk Matter Particle Explorer (DAMPE) is a pioneering calorimetric experiment that has been successfully operating in space since December 2015, designed to detect cosmic rays up to unprecedentedly high energies thanks to the fine-grained thick BGO calorimeter and relatively large geometric factor. Among the scientific goals of DAMPE are the precise measurements of cosmic-ray electron plus positron spectrum, including the detection of possible indirect dark matter signatures, spectral measurements of primary and secondary cosmic-ray species, and gamma-ray physics. For electrons and gamma rays, it covers an energy range from GeV to about 10 TeV, with an outstanding energy resolution close to 1%. Proton and ion cosmic rays can be measured up to hundreds of TeV in kinetic energy. In this contribution, we first give an overview of the DAMPE mission and its on-orbit operation status. Then, we highlight the key scientific results, including the measurements of the BCNO group, boron-to-carbon ratio, proton plus helium spectrum beyond 100 TeV, gamma-ray physics and more. Finally, the ongoing efforts for lepton, light, and heavy hadron cosmic rays are briefly discussed along with the new data analysis techniques.