Measurement of the Rb-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Xe</mml:mi></mml:mrow><mml:mprescripts /><mml:mrow /><mml:mrow><mml:mn>131</mml:mn></mml:mrow><mml:mrow /><mml:mrow /></mml:mmultiscripts></mml:mrow></mml:math>Spin-Exchange Cross Section in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Xe</mml:mi></mm

Volk, C. H.; Kwon, T. M.; Mark, J. G.; Kim, Y. B.; Woo, J. C.

doi:10.1103/physrevlett.44.136

Cited by 26 publications

(18 citation statements)

References 11 publications

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“…Although excessive RbH buildup on the cell entry window will reduce laser irradiation, deposition on other cell surfaces may not necessarily adversely affect the achievable noble gas spin polarization. Previous work demonstrated that the 131 Xe T 1 relaxation time increases for this spin I = 3/2 isotope because of RbH buildup (48)(49)(50). RbH surface coating may therefore also reduce the 83 Kr T 1 relaxation rates and improve SEOP.…”

mentioning

confidence: 94%

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Rogers

Hill-Casey

Stupic

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Hyperpolarized (hp) 83 Kr is a promising MRI contrast agent for the diagnosis of pulmonary diseases affecting the surface of the respiratory zone. However, the distinct physical properties of 83 Kr that enable unique MRI contrast also complicate the production of hp 83 Kr. This work presents a previously unexplored approach in the generation of hp 83 Kr that can likewise be used for the production of hp 129 Xe. Molecular nitrogen, typically used as buffer gas in spin-exchange optical pumping (SEOP), was replaced by molecular hydrogen without penalty for the achievable hyperpolarization. In this particular study, the highest obtained nuclear spin polarizations were P = 29% for 83 Kr and P = 63% for 129 Xe. The results were reproduced over many SEOP cycles despite the laser-induced on-resonance formation of rubidium hydride (RbH). Following SEOP, the H 2 was reactively removed via catalytic combustion without measurable losses in hyperpolarized spin state of either Xe can be obtained through dynamic nuclear polarization (25) with high spin-polarization levels of up to P = 30% (26) He-N 2 mixture or pure N 2 gas. The buffer gas serves a dual purpose as it prevents destructive radiation trapping, originating from radiative electronic relaxation of rubidium (27, 28), but also causes pressure broadening of the Rb D 1 linewidth. Rubidium line broadening maximizes adsorption of laser light emitted by high-power solid devices, even if those are line narrowed. Following SEOP, hp 129

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mentioning

confidence: 94%

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Rogers

Hill-Casey

Stupic

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…(b) The silicon chip footprint is 3 cm Â 1 cm, with a thickness of 1 mm. The dimensions of the pump and probe chambers are 5 mm Â 5 mm Â 1 mm and 3 mm Â 3 mm Â 1 mm, respectively, whereas the channel connecting the pump and probe chambers is 1 mm Â 0. magnetometers 13,18,19 sensitive to magnetic fields along the y-axis as defined in Fig. 1a, we detected the 129 Xe magnetization, and thus its polarization 20 129 Xe longitudinal polarization along the z-axis into the transverse x-y plane with a transverse DC magnetic field pulse, as shown in Fig.…”

Section: Resultsmentioning

confidence: 98%

Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip

et al. 2014

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Optically hyperpolarized 129 Xe gas has become a powerful contrast agent in nuclear magnetic resonance (NMR) spectroscopy and imaging, with applications ranging from studies of the human lung to the targeted detection of biomolecules. Equally attractive is its potential use to enhance the sensitivity of microfluidic NMR experiments, in which small sample volumes yield poor sensitivity. Unfortunately, most 129 Xe polarization systems are large and non-portable. Here we present a microfabricated chip that optically polarizes 129 Xe gas. We have achieved 129 Xe polarizations 40.5% at flow rates of several microlitres per second, compatible with typical microfluidic applications. We employ in situ optical magnetometry to sensitively detect and characterize the 129 Xe polarization at magnetic fields of 1 mT. We construct the device using standard microfabrication techniques, which will facilitate its integration with existing microfluidic platforms. This device may enable the implementation of highly sensitive 129 Xe NMR in compact, low-cost, portable devices.

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“…Grover (1978) detected the polarization enhancement of the heavier noble gases in the presence of polarized Rb using Rb as a magnetometer. Continuing this work, Volk et al (1980) recognized the effect of long-lived van der Waals molecules in the spin-exchange process, produced and destroyed in a three body process including N 2 , but largely overestimate the cross-section for binary processes. The first quantitative determination of the xenon polarization, and of the efficiency of the polarization transfer is due to Bhaskar et al (1982).…”

Section: Introductionmentioning

confidence: 85%

Hyperpolarized xenon in NMR and MRI

Oros¹,

2004

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Hyperpolarized gases have found a steadily increasing range of applications in nuclear magnetic resonance (NMR) and NMR imaging (MRI). They can be regarded as a new class of MR contrast agent or as a way of greatly enhancing the temporal resolution of the measurement of processes relevant to areas as diverse as materials science and biomedicine. We concentrate on the properties and applications of hyperpolarized xenon. This review discusses the physics of producing hyperpolarization, the NMR-relevant properties of 129 Xe, specific MRI methods for hyperpolarized gases, applications of xenon to biology and medicine, polarization transfer to other nuclear species and low-field imaging.

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Measurement of the Rb-Xe131Spin-Exchange Cross Section inXe

Cited by 26 publications

References 11 publications

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip

Hyperpolarized xenon in NMR and MRI

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Measurement of the Rb-Xe131Spin-Exchange Cross Section inXe

Cited by 26 publications

References 11 publications

Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents

Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip

Hyperpolarized xenon in NMR and MRI

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Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents