Measurement of the temperature-dependent speed of sound and change in Grüneisen parameter of tissue-mimicking materials

Bakaric, Marina; Ivory, Aoife M.; Zeqiri, Bajram; Cox, Ben; Treeby, Bradley E.

doi:10.1109/ultsym.2019.8925838

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Due to its high absorption coefficient across nearly all wavelengths, the carbon black cube experienced the most substantial temperature increase upon prolonged exposure to laser light, resulting in the largest mean increase in photoacoustic amplitude. This observation aligns with previous studies that established a correlation between temperature and photoacoustic amplitude through the temperature-dependent Gruneisen parameter (Shah et al 2008, Bakaric et al 2019.…”

Section: Discussionsupporting

confidence: 93%

Optical tuning of copolymer-in-oil tissue-mimicking materials for multispectral photoacoustic imaging

Khodaverdi,

Cinthio,

Reistad

et al. 2024

Biomed. Phys. Eng. Express

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Objective. The availability of tissue-mimicking materials (TMMs) for manufacturing high-quality phantoms is crucial for standardization, evaluating novel quantitative approaches, and clinically translating new imaging modalities, such as photoacoustic imaging (PAI). Recently, a gel comprising the copolymer styrene-ethylene/butylene-styrene (SEBS) in mineral oil has shown significant potential as TMM due to its optical and acoustic properties akin to soft tissue. We propose using artists’ oil-based inks dissolved and diluted in balsam turpentine to tune the optical properties. Approach. A TMM was fabricated by mixing a SEBS copolymer and mineral oil, supplemented with additives to tune its optical absorption and scattering properties independently. A systematic investigation of the tuning accuracies and relationships between concentrations of oil-based pigments and optical absorption properties of the TMM across visible and near-infrared wavelengths using collimated transmission spectroscopy was conducted. The photoacoustic spectrum of various oil-based inks was studied to analyze the effect of increasing concentration and depth. Main results. Artists’ Oil-based inks dissolved in turpentine proved effective as additives to tune the optical absorption properties of mineral oil SEBS-gel with high accuracy. The TMMs demonstrated long-term stability and suitability for producing phantoms with desired optical absorption properties for PAI studies. Significance. The findings, including tuning of optical absorption and spectral shape, suggest that this TMM facilitates the development of more sophisticated phantoms of arbitrary shapes. This approach holds promise for advancing the development of PAI, including investigation of the spectral coloring effect. In addition, it can potentially aid in the development and clinical translation of ultrasound optical tomography.

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Section: Discussionsupporting

confidence: 93%

Optical tuning of copolymer-in-oil tissue-mimicking materials for multispectral photoacoustic imaging

Khodaverdi,

Cinthio,

Reistad

et al. 2024

Biomed. Phys. Eng. Express

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“…The material candidates for the phantoms were characterised in a previously described setup for measuring the temperature dependence of the speed of sound and photoacoustic conversion efficiency. 2 This study included agar-based materials, 9,16 copolymer-in-oil, 10 gel wax, 13 polyvinyl chloride plastisol (PVCP) 3 and silicone. 21 The measurement results were verified by characterising degassed deionised water and comparing this to the literature data for the temperature-dependent Grüneisen parameter of water, which was calculated using the approximation Γ(T ) = 0.0053T + 0.0043 derived from the definition of the Grüneisen parameter (Γ = βc 2 Cp ) and knowledge of the temperature dependence of the speed of sound c, volume expansion thermal coefficient β and specific heat under constant volume C p for water and aqueous solutions.…”

Section: Materials and Methods 21 Phantommentioning

confidence: 99%

Test materials for characterising heating from HIFU devices using photoacoustic thermometry

Bakaric

Zeqiri

Cox

et al. 2020

Photons Plus Ultrasound: Imaging and Sensing 2020

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High intensity focused ultrasound (HIFU) is a non-invasive thermal therapy during which a focused ultrasound beam is used to destroy cells within a confined volume of tissue. Due to its increased use and advancements in treatment delivery, various numerical models are being developed for use in treatment planning software. In order to validate these models, as well as to perform routine quality checks and transducer characterisation, a temperature monitoring technique capable of accurately mapping the temperature rise induced is necessary. Photoacoustic thermometry is a rapidly emerging technique for non-invasive temperature monitoring, where the temperature dependence of the Grüneisen parameter leads to changes in the recorded photoacoustic signal amplitude with temperature. In order to use this technique to assess heating induced by HIFU in a metrology setting, a suitable test material must first be selected that exhibits an increase in the generated photoacoustic signal with temperature. In this study, the temperature dependence of the photoacoustic conversion efficiency (µ a Γ) of several tissue-mimicking materials was measured for temperatures between 22 • C and 50 • C. Materials included were agar-based phantoms, copolymer-in-oil, gel wax, PVA cryogels, PVCP and silicone. This information provided a basis for the development of a volumetric phantom, which was sonicated in a proof-of-concept integrated photoacoustic thermometry system for monitoring of HIFU-induced heating. The results show the suitability of agar-based phantoms and photoacoustic thermometry to image the 3D heat distribution generated by a HIFU transducer.

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On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography

Vu,

Klippel,

Canning

et al. 2024

IEEE Trans. Med. Imaging

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Measurement of the temperature-dependent speed of sound and change in Grüneisen parameter of tissue-mimicking materials

Cited by 4 publications

References 14 publications

Optical tuning of copolymer-in-oil tissue-mimicking materials for multispectral photoacoustic imaging

Optical tuning of copolymer-in-oil tissue-mimicking materials for multispectral photoacoustic imaging

Test materials for characterising heating from HIFU devices using photoacoustic thermometry

On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography

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