Measurement of the Temperature Field in a Brain Phantom with Simulated Glioblastoma in Transcranial High-Frequency Hyperthermia

Choynzonov, E. L.; Ryabova, A. I.; Miloichikova, I. A.; Turgunova, N.D.; Gribova, O. V.; Startseva, Zh. A.; Novikov, V. A.; Vasiljev, Roman; Krasnykh, A. A.; Cherepennikov, Yu.M.; Stuchebrov, S G

doi:10.1007/s10527-018-9746-7

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“…Results of thermometry showed that the temperature in the normal brain substance and cerebrospinal fluid did not exceed the physiologic parameters. The rise in the tumor temperature enhanced the efficacy of radiotherapy [83].…”

Section: Discussionmentioning

confidence: 99%

Concurrent Thermochemoradiotherapy in Glioblastoma Treatment: Preliminary Results

Ryabova¹,

Novikov²,

Gribova³

et al. 2019

Glioma - Contemporary Diagnostic and Therapeutic Approaches

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Glioblastoma is the most frequent and aggressive primary brain tumor. The patient can be alive with this pathology using the modern standard of intensive combined treatment less than 2 years. Between December 2013 and August 2017, 30 patients with newly diagnosed supratentorial glioblastoma had received concomitant chemoradiotherapy with transcranial radiofrequency hyperthermia. The gross total or the subtotal resection of the tumor was made previously in all cases. The median follow-up time after operation achieved 12 months (95% confidence interval (CI): 8.5-23 months) in this study. The median disease-free survival time was 9.6 months (95% CI: 7.2-19.0 months). The median overall survival time of patients included in the study was 23.4 months. No increase in the systemic side effects of chemotherapy was found compared with the frequency described in the population. Preliminary results had shown that the usage of concomitant thermochemoradiotherapy with transcranial radiofrequency hyperthermia improves progression-free survival rates. Overall survival rates also tended to increase. Given the absence of severe complications, it is necessary to continue research to achieve statistically significant results.

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Section: Discussionmentioning

confidence: 99%