The cross-section design of wood/polyvinyl chloride composite log-wall panels was studied for effects on compressive load, thermal and acoustic properties. Variation in the slenderness ratio (2, 4, 8, 10 and 12) on compressive load was also included. Two parameters of log-wall cross sections consisting of web thickness (3.5, 7.0 and 10.0 mm) and flange spacing (45, 60 and 90 mm) were also investigated. Experimental results indicated that higher web thickness and lower flange spacing of wood/polyvinyl chloride composite log-wall cross sections increased the ultimate compressive load and noise reduction. However, lateral deflection and thermal resistance decreased. Increasing the slenderness ratio of the log-wall panels resulted in lower ultimate compressive load and higher lateral deflection. Empirical equations for predicting the ultimate compressive load of wood/polyvinyl chloride composite log-wall panels in practical uses were proposed regarding web thickness, flange spacing and slenderness ratio.