Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

Bianchi, L.; Asadi, Somayeh; Landro, Martina De; Korganbayev, Sanzhar; Saccomandi, Paola

doi:10.1109/memea54994.2022.9856408

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…Since such processes are dependent upon the concentration of nanoparticles, their relative contribution to photothermal therapy can be controlled, leading to optimal nanoparticle loads, as discussed below. 42 10 0.3 tissue 24 10 750 thermal parameters 0.48% agarose 43 density (ρ) 1.03 g/mL thermal conductivity (k) 0.55 W/(m K) specific heat (c) 4200 J/(kg K) 0.8% agarose 43 density (ρ) 1.06 g/mL thermal conductivity (k) 0.5 W/(m K) specific heat (c) 4200 J/(kg K) tissue 44 density (ρ) 1.1 g/mL thermal conductivity (k) 0.55 W/(m K) specific heat (c) 4200 J/(kg K) other properties 44 blood perfusion 2) a slice in the nanoshell-free agarose medium (black, approximately 2 mm below the nanoshell band in the same NMR tube). In the experiments, a third temperature measurement was obtained as a reference (blue, water).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Routes to Optimizing Photothermal Cancer Therapy through a Comprehensive Theoretical Model

Naidu,

Kadria-Vili,

Neumann

et al. 2024

ACS Photonics

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Nanoparticle-assisted photothermal therapy is a soft tissue ablation method where nanoparticles embedded in tissue absorb near-infrared light, converting it to heat and raising temperatures directly where the nanoparticles are located, with minimal damage to adjacent tissue. Developing a method that accurately predicts light and heat dissipation within both pristine and nanoparticle-embedded tissues is essential for making this process as efficient as possible. Here, we report a theoretical model of nanoparticleassisted photothermal therapy that provides a deeper understanding of this process. The model considers light scattering and absorption by tissue and nanoparticles, resulting in heat generation and dissipation. We find that the thermal response is a consequence of two competing processes, increased light absorption and backscattering, both dependent on nanoparticle concentration, and we accurately account for temperature-dependent tissue properties. Through this approach, we found that spatial and temporal modulation of the laser intensity, combined with heat localization, can dramatically increase the efficiency of the ablation process, resulting in a 44% greater ablation volume in 33% less illumination time. Our critical examination of this therapeutic approach through a robust, datavalidated model offers valuable insights into practical strategies for potentially game-changing treatment optimization.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Routes to Optimizing Photothermal Cancer Therapy through a Comprehensive Theoretical Model

Naidu,

Kadria-Vili,

Neumann

et al. 2024

ACS Photonics

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“…The temperature range of interest set in the thermal bath was ~22 °C to >90 °C, and was divided into 10 steps for porcine kidneys and 9 steps for bovine kidneys. The TEMPOS thermal properties analyzer equipped with an SH-3 dual-needle sensor was used to measure k and α , according to the transient line heat source method [ 7 , 9 , 12 , 33 , 37 , 38 , 39 ]. The adopted measurement instrument based on the transient line heat source method is characterized by several advantages in comparison with standard steady-state techniques for the measurement of thermal properties [ 56 , 57 ].…”

Section: Experimental Procedures and Methods For Data Analysismentioning

confidence: 99%

“…The measurement of thermal properties was performed in steady-state conditions in a temperature-monitored environment by means of the transfer hot-wire technique employing a dual-needle probe. The measurement accuracy of the system was validated by our research group in previous studies [12,33,39], and its accurate reading capability has also been assessed in the present work by testing the measurement instrument on a polymeric standard material. The quantitative values of the measured thermal properties of biological tissues are presented, along with the estimation of the measurement uncertainty, the best-fit regression models interpolating the experimental data, and the analysis of the residual values.…”

Section: Introductionmentioning

confidence: 91%

“…Self-heated thermistor probes have been utilized to measure the k and α of various human and animal tissues and assess their temperature dependence [ 34 , 35 , 36 ]. Moreover, in more recent years, the dual-needle technique based on the transient hot-wire method has been employed for the estimation of the thermal properties of porcine, bovine and ovine liver; muscle; porcine brain; pancreas; lung and heart [ 7 , 12 , 33 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C

Bianchi,

Fiorentini,

Gianella

et al. 2023

Sensors

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This experimental study aimed to characterize the thermal properties of ex vivo porcine and bovine kidney tissues in steady-state heat transfer conditions in a wider thermal interval (23.2–92.8 °C) compared to previous investigations limited to 45 °C. Thermal properties, namely thermal conductivity (k) and thermal diffusivity (α), were measured in a temperature-controlled environment using a dual-needle probe connected to a commercial thermal property analyzer, using the transient hot-wire technique. The estimation of measurement uncertainty was performed along with the assessment of regression models describing the trend of measured quantities as a function of temperature to be used in simulations involving heat transfer in kidney tissue. A direct comparison of the thermal properties of the same tissue from two different species, i.e., porcine and bovine kidney tissues, with the same experimental transient hot-wire technique, was conducted to provide indications on the possible inter-species variabilities of k and α at different selected temperatures. Exponential fitting curves were selected to interpolate the measured values for both porcine and bovine kidney tissues, as well as for both k and α. The results show that the k and α values of the tissues remained rather constant from room temperature up to the onset of water evaporation, and a more marked increase was observed afterward. Indeed, at the highest investigated temperatures, i.e., 90.0–92.8 °C, the average k values were subject to 1.2- and 1.3-fold increases, compared to their nominal values at room temperature, in porcine and bovine kidney tissue, respectively. Moreover, at 90.0–92.8 °C, 1.4- and 1.2-fold increases in the average values of α, compared to baseline values, were observed for porcine and bovine kidney tissue, respectively. No statistically significant differences were found between the thermal properties of porcine and bovine kidney tissues at the same selected tissue temperatures despite their anatomical and structural differences. The provided quantitative values and best-fit regression models can be used to enhance the accuracy of the prediction capability of numerical models of thermal therapies. Furthermore, this study may provide insights into the refinement of protocols for the realization of tissue-mimicking phantoms and the choice of tissue models for bioheat transfer studies in experimental laboratories.

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“…The thermal properties were then estimated by the analyzer, which computes the minimization of mean square error between the measured temperature changes and those obtained by a mathematical heat transfer model, implemented in the software of the system. In particular, the k and α are estimated by the thermal analyzer through the following equations [11], [18]: 2 4 4…”

Section: Measurement Of the Thermal Propertiesmentioning

confidence: 99%

Characterization of the Optical and Thermal Properties of Cardiac Tissue as a Function of Temperature

Bianchi,

Bossi,

Pifferi

et al. 2023

2023 45th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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In this work, we devised the first characterization of the optical and thermal properties of ex vivo cardiac tissue as a function of different selected temperatures, ranging from room temperature to hyperthermic and ablative temperatures. The broadband (i.e., from 650 nm to 1100 nm) estimation of the optical properties, i.e., absorption coefficient (μa) and reduced scattering coefficient (μ's), was performed by means of timedomain diffuse optics. Besides, the measurement of the thermal properties was based on the transient hot-wire technique, employing a dual-needle probe to estimate the tissue thermal conductivity (k), thermal diffusivity (α), and volumetric heat capacity (Cv). Increasing the tissue temperature led to variations in the spectral characteristics of μa (e.g., the redshift of the 780 nm peak, the rise of a new peak at 840 nm, and the formation of a valley at 900 nm). Moreover, an increase in the values of μ's was assessed as tissue temperature raised (e.g., for 800 nm, at 25 °C μ's= 9.8 cm -1 , while at 77 °C μ's= 29.1 cm -1 ). Concerning the thermal properties characterization, k was almost constant in the selected temperature interval. Conversely, α and Cv were subjected to an increase and a decrease with temperature, respectively; thus, they registered values of 0.190 mm 2 /s and 3.03 MJ/(m 3 •K) at the maximum investigated temperature (79 °C), accordingly. Clinical Relevance-The experimentally obtained optical and thermal properties of cardiac tissue are useful to improve the accuracy of simulation-based tools for thermal therapy planning. Furthermore, the measured properties can serve as a reference for the realization of tissue-mimicking phantoms for medical training and testing of medical instruments. I. INTRODUCTIONAccurate information on the physical properties of biological tissues is fundamental for improving diagnostic and therapeutic procedures and medical treatments. Hence, many efforts have been devoted, in the field of bioengineering, to the evaluation of optical, thermal, mechanical, and dielectric properties of biological media [1], [2]. In this regard, the investigation of the optical and thermal behavior of tissues is pivotal for the realization of tissue-mimicking materials [3], [4], employed for fine-tuning and the pre-clinical testing of medical devices, as well as for medical training, and the implementation of numerical models for therapy preplanning. These models are indeed useful to foresee the outcome of interventional procedures and select the best treatment strategy [5]- [7]. However, their accuracy and prediction capabilities

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Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

Cited by 5 publications

References 35 publications

Routes to Optimizing Photothermal Cancer Therapy through a Comprehensive Theoretical Model

Routes to Optimizing Photothermal Cancer Therapy through a Comprehensive Theoretical Model

Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C

Characterization of the Optical and Thermal Properties of Cardiac Tissue as a Function of Temperature

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