Measurement of trypanotolerance criteria and their effect on reproductive performance of N'Dama cattle

Trail, J.C.M.; D'Ieteren, G.D.M.; Murray, M.; Ordner, G.; Yangari, G.; Collardelle, C.; Sauveroche, B.; Maille, J.C.; Viviani, P.

doi:10.1016/0304-4017(93)90079-3

Cited by 28 publications

(9 citation statements)

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“…Studying PCV, which is considered as a good indicator for simply assessing trypanotolerance as anaemia is the main pathogenic feature of infection by T . congolense and is correlated to growth [ 23 ], [ 19 ], [ 57 ], and to reproductive performances [ 58 ], we first confirmed the trypanosusceptibility status of ZFU and the trypanotolerant status of NDA.…”

Section: Discussionmentioning

confidence: 65%

A Comparison of Phenotypic Traits Related to Trypanotolerance in Five West African Cattle Breeds Highlights the Value of Shorthorn Taurine Breeds

et al. 2015

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BackgroundAnimal African Trypanosomosis particularly affects cattle and dramatically impairs livestock development in sub-Saharan Africa. African Zebu (AFZ) or European taurine breeds usually die of the disease in the absence of treatment, whereas West African taurine breeds (AFT), considered trypanotolerant, are able to control the pathogenic effects of trypanosomosis. Up to now, only one AFT breed, the longhorn N’Dama (NDA), has been largely studied and is considered as the reference trypanotolerant breed. Shorthorn taurine trypanotolerance has never been properly assessed and compared to NDA and AFZ breeds.Methodology/Principal FindingsThis study compared the trypanotolerant/susceptible phenotype of five West African local breeds that differ in their demographic history. Thirty-six individuals belonging to the longhorn taurine NDA breed, two shorthorn taurine Lagune (LAG) and Baoulé (BAO) breeds, the Zebu Fulani (ZFU) and the Borgou (BOR), an admixed breed between AFT and AFZ, were infected by Trypanosoma congolense IL1180. All the cattle were genetically characterized using dense SNP markers, and parameters linked to parasitaemia, anaemia and leukocytes were analysed using synthetic variables and mixed models. We showed that LAG, followed by NDA and BAO, displayed the best control of anaemia. ZFU showed the greatest anaemia and the BOR breed had an intermediate value, as expected from its admixed origin. Large differences in leukocyte counts were also observed, with higher leukocytosis for AFT. Nevertheless, no differences in parasitaemia were found, except a tendency to take longer to display detectable parasites in ZFU.ConclusionsWe demonstrated that LAG and BAO are as trypanotolerant as NDA. This study highlights the value of shorthorn taurine breeds, which display strong local adaptation to trypanosomosis. Thanks to further analyses based on comparisons of the genome or transcriptome of the breeds, these results open up the way for better knowledge of host-pathogen interactions and, furthermore, for identifying key biological pathways.

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Section: Discussionmentioning

confidence: 65%

A Comparison of Phenotypic Traits Related to Trypanotolerance in Five West African Cattle Breeds Highlights the Value of Shorthorn Taurine Breeds

et al. 2015

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“…The development of anemia is one of the most common signs of disease caused by hemoparasites in susceptible cattle. The level of anemia or PCV usually gives a reliable indication of the disease status and the productive performance of an infected animal [27, 28]. The measurement of the PCV of non-infected animals helps to form a baseline for the comparison of PCVs among the sampled animals, because the PCV value is affected by confounding factors other than parasitic infections [30].…”

Section: Discussionmentioning

confidence: 99%

A PCR-based survey of animal African trypanosomosis and selected piroplasm parasites of cattle and goats in Zambia

Musinguzi

Suganuma

Asada

et al. 2016

The Journal of Veterinary Medical Science

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We screened cattle and goats from the districts of Chama, Monze and Mumbwa in Zambia for animal African trypanosomes, Babesia bigemina and Theileria parva using PCRs; 38.1% of the samples tested positive for at least one of the parasite species. The most common parasite was Trypanosoma vivax (19.8%). Its incidence was significantly higher in goats than in cattle, (P<0.05). B. bigemina was found in samples from all the three areas, making it the most widespread of the parasites in Zambia. Among the tested samples, 12.0% of the positive samples were mixed infections. There were significant differences in the infection rates of T. vivax (Mumbwa had a significantly higher infection rate [39.6%, P<0.0001]), Th. parva (Monze had the only cases [P<0.0004]) and B. bigemina (Monze had a significantly higher infection rate [40.5%, P<0.0001]). According to the hematocrit values, the packed cell volume (%) among the cattle with mixed infections was significantly lower than that of the other cattle. The presence of multiple parasite species and mixed infections among the Zambian cattle and goat populations is of both clinical and economic importance to livestock farming. The absence of trypanosomosis among the samples from Monze can be attributed to tsetse eradication efforts that took place around Lake Kariba. This shows that the prevention and control of these parasitic diseases can have a significant impact on the disease status, which can translate directly into the improvement of the livestock sector in Zambia.

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“…A maior predisposição à helmintose como conseqüên-cia da infecção por T. vivax foi confirmada por Trail et al (1993) que verificaram que bovinos infectados por T. vivax foram mais freqüentemente parasitados por helmintos e apresentaram maiores valores de ovos por grama de fezes. A presença do T. vivax em esfregaços sangüíneos de caprinos e ovinos que apresentam infecção simultânea por Haemonchus tem levado a dificuldade de avaliação do efeito primário da infecção por T. vivax, uma vez que a anemia freqüentemente relatada nos casos de infecção por T. vivax poderá estar associada à hematofagia realizada pelo citado helminto (Applewaite 1990).…”

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Infecção experimental por Trypanosoma vivax em ovinos

et al. 2006

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O presente estudo teve por objetivo avaliar as alterações clínicas, hematológicas e patológicas em ovinos infectados experimentalmente com Trypanosoma vivax, utilizando-se um isolado proveniente de bovinos infectados naturalmente no município de Catolé do Rocha, Paraíba. Quatro ovinos da raça Santa Inês foram infectados por via intravenosa com 1ml de sangue contendo 1,85x10(5) tripomastigotas de T. vivax e outros quatro ovinos foram destinados ao grupo controle. A parasitemia e a temperatura foram determinadas diariamente durante 30 dias após a infecção (dpi) e quinzenalmente dos 31 aos 90 dias. A cada 15 dias os animais foram pesados e realizados coletas de sangue para hemograma. Um ovino morreu aos 75 dpi, os demais animais do grupo infectado e do grupo controle foram sacrificados 90 dias após o início do experimento. T. vivax foi evidenciado a partir do 4º dpi em todos os ovinos infectados. A parasitemia foi constante até os 15 dias e irregular entre os 16 e 30 dias. Após o 30º dia não foram observados parasitas no sangue. Foi observada correlação linear positiva entre temperatura retal e parasitemia [Y=0,027x + 38,515; R²=0,9444 (P<0,05)]. Diferença significativa do peso entre os grupos infectado e controle foi verificada a partir do 30º ao 90º dpi. Do 30º ao 90º os animais apresentaram anemia e leucopenia. As lesões macroscópicas encontradas na necropsia foram palidez da carcaça, aumento generalizado dos linfonodos e do baço, e discreta quantidade de líquido nas cavidades peritoneal e pericárdica. Histologicamente, em todos os animais infectados foi observada miocardite multifocal mononuclear. Concluiu-se que o isolado é patogênico para ovinos. Sugere-se que a região semi-árida onde ocorreu o surto, não é endêmica para a tripanossomíase e a doença pode ocorrer se o parasita for introduzido na presença de vetores.

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Measurement of trypanotolerance criteria and their effect on reproductive performance of N'Dama cattle

Cited by 28 publications

References 6 publications

A Comparison of Phenotypic Traits Related to Trypanotolerance in Five West African Cattle Breeds Highlights the Value of Shorthorn Taurine Breeds

A Comparison of Phenotypic Traits Related to Trypanotolerance in Five West African Cattle Breeds Highlights the Value of Shorthorn Taurine Breeds

A PCR-based survey of animal African trypanosomosis and selected piroplasm parasites of cattle and goats in Zambia

Infecção experimental por Trypanosoma vivax em ovinos

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