Measurement of Ultrasonic Properties into Biological Tissues in the Hyperthermia Temperature Range

Lopez-Haro, S. A.; Leija, L.; Favari, Liliana; Vera, A.

doi:10.1016/j.phpro.2010.01.071

Cited by 16 publications

(17 citation statements)

References 5 publications

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“…The attenuation versus frequency data for liver samples calculated in this study can also be expressed as a power-law of the form 1.08 dBcm -1 MHz -1 (R 2 =0.66). This power-law was found to be in good agreement (± 0.42 dB cm -1 ) with those power-laws reported from pig (1.2 dBcm -1 MHz -1 , López-Haro et al, (2009)), rat (1.3 ± 0.09 dBcm -1 MHz -1 , O'Brien et al, (1988)) and human (1.6 ± 0.21 dBcm -1 MHz -1 , Lu et al, (1999), 1.5 dBcm -1 MHz -1 , Gammell et al, (1977)) livers.…”

Section: *Detailed Response To Reviewerssupporting

confidence: 88%

Acoustic Properties of Small Animal Soft Tissue in the Frequency Range 12–32 MHz

Rabell-Montiel

Thomson

Anderson

et al. 2018

Ultrasound in Medicine & Biology

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Quality assurance phantoms are made of tissue-mimicking materials (TMMs) the acoustic properties of which mimic those of soft tissue. However, the acoustic properties of many soft tissue types have not been measured at ultrasonic frequencies >9 MHz. With the increasing use of high-frequency ultrasound for both clinical and pre-clinical applications, it is of increasing interest to ensure that TMMs accurately reflect the acoustic properties of soft tissue at these higher frequencies. In this study, the acoustic properties of ex vivo brain, liver and kidney samples from 50 mice were assessed in the frequency range 12-32 MHz. Measurements were performed within 6 min of euthanasia in a phosphate-buffered saline solution maintained at 37.2 ± 0.2 °C. The measured mean values for the speed of sound for all organs were found to be higher than the International Electrotechnical Commission guideline recommended value for TMMs. The attenuation coefficients measured for brain, liver and kidney samples were compared with the results of previous studies at lower frequencies. Only the measured kidney attenuation coefficient was found to be in good agreement with the International Electrotechnical Commission guideline. The information provided in this study can be used as a baseline on which to manufacture a TMM suitable for high-frequency applications.

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Section: *Detailed Response To Reviewerssupporting

confidence: 88%

Acoustic Properties of Small Animal Soft Tissue in the Frequency Range 12–32 MHz

Rabell-Montiel

Thomson

Anderson

et al. 2018

Ultrasound in Medicine & Biology

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show abstract

“…The acoustic properties of brain, liver, and kidney, among other organs, have previously been measured from small animals at low frequencies , humans , chickens and mammals López-Haro et al, 2009;. These studies measured the acoustic properties up to 9 MHz at either room temperature (22 -26°C) or at a normal human temperature (37°C).…”

Section: Acoustic Properties Of Soft Tissuementioning

confidence: 99%

The acoustical properties of IEC agar-based tissue mimicking material over the frequency range 4.5MHz to 50MHz - a longitudinal study

Rabell-Montiel

Pye

Anderson

et al. 2016

2016 IEEE International Ultrasonics Symposium (IUS)

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Commercially available ultrasound quality assurance test phantoms rely on the long-term acoustic stability of the tissue-mimicking-material (TMM). Measurement of the acoustic properties of the TMM can be technically challenging, and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique was proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range 4.5-50 MHz at 0, 6 and 12 months using both techniques. For both techniques, the measured mean values for the speed of sound and attenuation were very similar and within the International Electrotechnical Commission-recommended value. However, the results obtained using the proposed modified technique exhibited greater stability over the 1-y period compared with the results acquired using the standard technique.

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“…The reported speed of sound and pressure attenuation coefficient for muscular tissue were 1550–1620 m/s and 4.0 Np/m, respectively [36, 38]; these properties were measured for the phantom at 37°C, with respective values of 1553 ± 12 m/s and 5.98 ± 0.46 Np/m. Both values were considered constant in simulations.…”

Section: Resultsmentioning

confidence: 99%

Experimental Verification of Modeled Thermal Distribution Produced by a Piston Source in Physiotherapy Ultrasound

Gutiérrez

Lopez-Haro

Vera

et al. 2016

BioMed Research International

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Objectives. To present a quantitative comparison of thermal patterns produced by the piston-in-a-baffle approach with those generated by a physiotherapy ultrasonic device and to show the dependency among thermal patterns and acoustic intensity distributions. Methods. The finite element (FE) method was used to model an ideal acoustic field and the produced thermal pattern to be compared with the experimental acoustic and temperature distributions produced by a real ultrasonic applicator. A thermal model using the measured acoustic profile as input is also presented for comparison. Temperature measurements were carried out with thermocouples inserted in muscle phantom. The insertion place of thermocouples was monitored with ultrasound imaging. Results. Modeled and measured thermal profiles were compared within the first 10 cm of depth. The ideal acoustic field did not adequately represent the measured field having different temperature profiles (errors 10% to 20%). Experimental field was concentrated near the transducer producing a region with higher temperatures, while the modeled ideal temperature was linearly distributed along the depth. The error was reduced to 7% when introducing the measured acoustic field as the input variable in the FE temperature modeling. Conclusions. Temperature distributions are strongly related to the acoustic field distributions.

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Measurement of Ultrasonic Properties into Biological Tissues in the Hyperthermia Temperature Range

Cited by 16 publications

References 5 publications

Acoustic Properties of Small Animal Soft Tissue in the Frequency Range 12–32 MHz

Acoustic Properties of Small Animal Soft Tissue in the Frequency Range 12–32 MHz

The acoustical properties of IEC agar-based tissue mimicking material over the frequency range 4.5MHz to 50MHz - a longitudinal study

Experimental Verification of Modeled Thermal Distribution Produced by a Piston Source in Physiotherapy Ultrasound

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