2019
DOI: 10.1016/j.urolonc.2018.12.024
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Measurement of Urinary Level of a Specific Competing endogenous RNA network (FOS and RCAN mRNA/ miR-324-5p, miR-4738-3p, /lncRNA miR-497-HG) Enables Diagnosis of Bladder Cancer

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Cited by 32 publications
(40 citation statements)
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“…Although significant results regarding miRNAs as diagnostic tools have been proposed in both blood-derived and urine biospecimen separately, a higher accuracy might be achieved by combining measurements of different classes of ncRNAs from different body fluids. Indeed, some authors have already proposed diagnostic biomarker combinations of different RNA classes [60], with excellent results. Recent advances in this field are promising and await translation into clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…Although significant results regarding miRNAs as diagnostic tools have been proposed in both blood-derived and urine biospecimen separately, a higher accuracy might be achieved by combining measurements of different classes of ncRNAs from different body fluids. Indeed, some authors have already proposed diagnostic biomarker combinations of different RNA classes [60], with excellent results. Recent advances in this field are promising and await translation into clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…BC patients presented higher expression levels of miR-324-5p, miR-4738-3p, and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) mRNA, and lower expression levels of lncRNA miR-497-HG and Regulator of Calcineurin 1 (RCAN1) mRNA on voided urine. When directly compared with cytology that presented an accuracy of 69.9%, the potential biomarker with lowest accuracy was lncRNA miR-497-HG with 78.3% and the highest, with 99.3% accuracy, were FOSB mRNA and RCAN1 mRNA, with a specificity of 98.9%, exhibited more sensitivity than cytology [89].…”
Section: Lncrnas Biomarkersmentioning
confidence: 97%
“…Eissa et al [89] evaluated the expression levels of several miRNAs, lncRNAs, and gene expression in the plasma and voided urine of patients with BC, patients with benign urological conditions, such as benign prostatic hyperplasia or bilharzial cystitis, and healthy controls. BC patients presented higher expression levels of miR-324-5p, miR-4738-3p, and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) mRNA, and lower expression levels of lncRNA miR-497-HG and Regulator of Calcineurin 1 (RCAN1) mRNA on voided urine.…”
Section: Lncrnas Biomarkersmentioning
confidence: 99%
“…MIR497HG is a host gene of the miR-497 and miR-195 embedded in its rst intron. MIR497HG was signi cantly downregulated and might serve as a potential diagnostic marker in BCa [15]. MiR-495 and miR-195 were also reduced in BCa and inhibited cancer cell progression [16,37,38].…”
Section: Discussionmentioning
confidence: 96%
“…MiR-17 ~ 92 cluster miRNAs encoded by MIR17HG downregulates TGF-β and STAT3 signaling in feingold syndrome mouse models [14]. LncRNA MIR497HG and derived miR-497 ~ 195 cluster are downregulated in BCa [15,16].…”
Section: Introductionmentioning
confidence: 99%