Measurement ofR′2in the Presence of Multiple Spectral Components Using Reference Spectrum Deconvolution

Wehrli, Félix W.; Ma, Jingfei; Hopkins, Jeffrey A.; Song, Hee Kwon

doi:10.1006/jmre.1997.1327

Cited by 38 publications

(25 citation statements)

References 14 publications

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“…As in (17) the assumption of a similar chemical composition of the muscle lipids and the lipids in BM is crucial for the procedure. However, it is known that the chemical composition of muscle lipids and adipose tissue as subcutaneous fat or tibial bone marrow lipids is nearly the same (15)(16)(17). No trabecular structures exist in the mid-tibia in contrast to the upper femur and only fatty acid triglycerides are measured in the rather homogenous surroundings.…”

Section: Discussionmentioning

confidence: 95%

“…In a former work the principle of deconvolution has been used for measuring the contribution of trabecular bone structure and density of the upper femur to the effective transverse relaxation time in trabecular yellow bone marrow (17). Using a signal out of subcutaneous tissue as a reference and assuming a line broadening function with an exponential decay, line broadening could be estimated by division and fitting in time domain.…”

Section: Discussionmentioning

confidence: 99%

“…This approach is reasonable, because from a biochemical point of view it is clear that the mentioned characteristic line pattern of lipids must exist: IMCL, EMCL, and adipose tissue as subcutaneous fat tissue or tibial bone marrow lipids (BM) are known to consist mainly of the same composition of fatty acid triglycerides (15)(16)(17). For this reason, spectra of yellow bone marrow recorded with identical measurement parameters can be used to assess the required characteristic line pattern of lipids.…”

Section: Introductionmentioning

confidence: 99%

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Separation of Intra- and Extramyocellular Lipid Signals in Proton MR Spectra by Determination of Their Magnetic Field Distribution

Steidle

Machann

Claussen

et al. 2002

Journal of Magnetic Resonance

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Separation of Intra- and Extramyocellular Lipid Signals in Proton MR Spectra by Determination of Their Magnetic Field Distribution

Steidle

Machann

Claussen

et al. 2002

Journal of Magnetic Resonance

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“…Lastly, R 0 2 can be estimated by deconvolving the amplitude-modulated signal with a reference signal (50). If the marrow composition is known (e.g.…”

Section: Nature Of the Susceptibility-induced Fieldmentioning

confidence: 99%

Quantitative MRI for the assessment of bone structure and function

et al. 2006

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Osteoporosis is the most common degenerative disease in the elderly. It is characterized by low bone mass and structural deterioration of bone tissue, leading to morbidity and increased fracture risk in the hip, spine and wrist-all sites of predominantly trabecular bone. Bone densitometry, currently the standard methodology for diagnosis and treatment monitoring, has significant limitations in that it cannot provide information on the structural manifestations of the disease. Recent advances in imaging, in particular MRI, can now provide detailed insight into the architectural consequences of disease progression and regression in response to treatment. The focus of this review is on the emerging methodology of quantitative MRI for the assessment of structure and function of trabecular bone. During the past 10 years, various approaches have been explored for obtaining image-based quantitative information on trabecular architecture. Indirect methods that do not require resolution on the scale of individual trabeculae and therefore can be practiced at any skeletal location, make use of the induced magnetic fields in the intertrabecular space. These fields, which have their origin in the greater diamagnetism of bone relative to surrounding marrow, can be measured in various ways, most typically in the form of R 0 2 , the recoverable component of the total transverse relaxation rate. Alternatively, the trabecular network can be quantified by high-resolution MRI (m-MRI), which requires resolution adequate to at least partially resolve individual trabeculae. Micro-MRI-based structure analysis is therefore technically demanding in terms of image acquisition and algorithms needed to extract the structural information under conditions of limited signal-to-noise ratio and resolution. Other requirements that must be met include motion correction and image registration, both critical for achieving the reproducibility needed in repeat studies. Key clinical applications targeted involve fracture risk prediction and evaluation of the effect of therapeutic intervention.

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“…Magnetic resonance imaging (MRI) provides unique capabilities for the study of the structural aspects of both trabecular and cortical bone, allowing in vivo, noninvasive, three-dimensional (3D) structure assessment without the use of ionizing radiation. Previous studies have demonstrated the usefulness of both high-resolution imaging (HR-MRI) [1][2][3][4][5][6] and MR relaxometry [7][8][9][10][11] for deriving structural parameters for the assessment of trabecular bone. For the current study we are concerned with HR-MRI, in which the trabecular structure is determined indirectly from a scan in which the bone marrow shows as a high intensity and the signal voids are assumed to be volumes of bone.…”

Section: Introductionmentioning

confidence: 99%

Processing and Analysis of In Vivo High-Resolution MR Images of Trabecular Bone for Longitudinal Studies: Reproducibility of Structural Measures and Micro-Finite Element Analysis Derived Mechanical Properties

2002

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Measurement ofR′2in the Presence of Multiple Spectral Components Using Reference Spectrum Deconvolution

Cited by 38 publications

References 14 publications

Separation of Intra- and Extramyocellular Lipid Signals in Proton MR Spectra by Determination of Their Magnetic Field Distribution

Separation of Intra- and Extramyocellular Lipid Signals in Proton MR Spectra by Determination of Their Magnetic Field Distribution

Quantitative MRI for the assessment of bone structure and function

Processing and Analysis of In Vivo High-Resolution MR Images of Trabecular Bone for Longitudinal Studies: Reproducibility of Structural Measures and Micro-Finite Element Analysis Derived Mechanical Properties

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