2021
DOI: 10.1016/j.forsciint.2021.110744
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Measurement uncertainty in quantifying delta-9-tetrahydrocannabinol (THC) in blood using SPE and LC/MS/MS

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Cited by 14 publications
(7 citation statements)
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“…Relative standard uncertainties ( u ) for the THC determination estimated at the 3 and 10 ng/mL levels were about 8% and 11%, respectively. Such values are consistent with data obtained by other authors adopting similar approaches 16 …”
Section: Resultssupporting
confidence: 93%
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“…Relative standard uncertainties ( u ) for the THC determination estimated at the 3 and 10 ng/mL levels were about 8% and 11%, respectively. Such values are consistent with data obtained by other authors adopting similar approaches 16 …”
Section: Resultssupporting
confidence: 93%
“…In addition, a decision rule was set with confidence for forensic purposes to evaluate the impact of measurement uncertainty (MU) on the determination of THC levels in real case samples. 16 The method was tested during a period of about 4 years on 7620 whole blood samples, including 641 positive ones, collected from drivers involved in road accidents, suspected of DUI of cannabis, and/or other psychoactive drugs. The 2-mL autosampler vials, glass inserts, and PTFE/silicone septa used for sampling were purchased from Agilent Technologies (Milan, Italy).…”
Section: Introductionmentioning
confidence: 99%
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“…Furthermore, the characterization of matrix RMs can be performed by multiple laboratories. ISO Guide 35 provides guidance on the characterization and assessment of homogeneity, stability, and the method for interlaboratory tests …”
Section: Methodsmentioning
confidence: 99%
“…ISO Guide 35 provides guidance on the characterization and assessment of homogeneity, stability, and the method for interlaboratory tests. 19 The combined standard uncertainty (u c ) of the concentration for our in-house matrix RM was estimated by aggregating the contributions from the value assignment (u char ), homogeneity (u bb ), and uncertainty owing to longterm instability (u s ). Figure 2 shows the sources of uncertainty introduced during development of the in-house matrix RM.…”
Section: ■ Experimental Sectionmentioning
confidence: 99%