Measurements of drugs and metabolites in biological matrices using SFC and SFE-SFC-MS

Drennan, Brady W.; Wicker, A. Paige; Berger, Blair K.; Schug, Kevin A.

doi:10.1016/b978-0-323-88487-7.00004-8

Cited by 2 publications

(1 citation statement)

References 80 publications

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“…Recent developments in analytical chemistry include dereplication and high content screening (HCS). Dereplication refers to a process for the fast identification of known secondary metabolites in natural products, in which MS-based methods are key to the success of that process [ 42 , 43 , 44 ], and HCS methods are those that combine automated microscopy with living cell-based assays [ 45 , 46 , 47 , 48 ], which allows, e.g., the screening of plant extract libraries and subsequent selection of the best hits based on the phenotypic screening results. However, the isolation of chemical compounds from crude natural extracts remains a major challenge in the field [ 42 ].…”

Section: Omics-based Strategies For Targeted Isolation Of Natural Pro...mentioning

confidence: 99%

Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022

et al. 2023

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Malaria kills more than 500,000 people yearly, mainly affecting Africa and Southeast Asia. The disease is caused by the protozoan parasite from the genus Plasmodium, with Plasmodium vivax and Plasmodium falciparum being the main species that cause the disease in humans. Although substantial progress has been observed in malaria research in the last years, the threat of the spread of Plasmodium parasites persists. Artemisinin-resistant strains of this parasite have been reported mainly in Southeast Asia, highlighting the urgent need to develop more effective and safe antimalarial drugs. In this context, natural sources, mainly from flora, remain underexplored antimalarial spaces. The present mini-review explores this space focusing on plant extracts and some of their isolated natural products with at least in vitro antiplasmodial effects reported in the literature comprising the last five years (2018–2022).

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Section: Omics-based Strategies For Targeted Isolation Of Natural Pro...mentioning

confidence: 99%

Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022

et al. 2023

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Bioactive Compounds from Organic Waste

Parra-Pacheco,

Cruz-Moreno,

Aguirre-Becerra

et al. 2024

Molecules

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The reuse and reincorporation of waste are the principles of circular economies. Compost, biofuels, animal feed, dyes, and bioactive compounds can be obtained from the revaluation of organic waste. Research on this subject is scarce and limited to specific sectors, such as agriculture and agroindustry, leaving aside others that generate large quantities of organic waste, such as floriculture. The remains of these sectors have a low decomposition rate compared to other organic wastes. They are a source of bioactive compounds (e.g., essential oils, pigments, phenols) that can be reincorporated into the production chain of various industries. This review describes the composition of waste from agroindustry, agriculture, and floriculture, analyzing their potential revalorization as a source of bioactive compounds and an alternative supply source.

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Measurements of drugs and metabolites in biological matrices using SFC and SFE-SFC-MS

Cited by 2 publications

References 80 publications

Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022

Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022

Bioactive Compounds from Organic Waste

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